HES7 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000179111 T034326_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HES7
M02802_2.00		 Homo sapiens
YGGCACGTGCCR
YGGCACGTGCCR		 SELEX
Jolma et al.(2013)
HES7_1		 (Direct) (Direct)
HES7
M04191_2.00		 Homo sapiens
NVCRCGTGSC
GSCACGYGBN		 SELEX
Yin et al.(2017)
HES7_eDBD_HT-SELEX		 (Direct) (Direct)
HES7
M04192_2.00		 Homo sapiens
NVCRCRTGVV
BBCAYGYGBN		 SELEX
Yin et al.(2017)
HES7_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hes7
M01727_2.00 		Mus musculus
NVCACGHGNN
NNCDCGTGBN		 PBM
Weirauch et al.(2014)
pTH5260 		0.914 0.981
Hes7
M09887_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES7_02 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000314774 bHLH 14 69
ENSP00000446205 bHLH 14 69
ENSP00000462491 bHLH 6 61

Links

Other bHLH family TFs
Other Homo sapiens TFs

27 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000023839 Papio anubis ENSPANG00000023839 I 0.914
ENSPPYG00000007948 Pongo abelii ENSPPYG00000007948 I 0.914
HES7 Otolemur garnettii ENSOGAG00000026608 I 0.914
HES7 Ornithorhynchus anatinus ENSOANG00000022456 I 0.914
ENSNLEG00000009871 Nomascus leucogenys ENSNLEG00000009871 I 0.914
HES7 Pan troglodytes ENSPTRG00000008725 I 0.914
HES7 Pteropus vampyrus ENSPVAG00000016370 I 0.914
HES7 Tursiops truncatus ENSTTRG00000010312 I 0.914
ENSSTOG00000025336 Ictidomys tridecemlineatus ENSSTOG00000025336 I 0.914
HES7 Sus scrofa ENSSSCG00000017982 I 0.914
Hes7 Rattus norvegicus ENSRNOG00000007391 I 0.914
Hes7 Mus musculus ENSMUSG00000023781 D 0.914
ENSMPUG00000008217 Mustela putorius furo ENSMPUG00000008217 I 0.914
Hes7 Dipodomys ordii ENSDORG00000003869 I 0.914
HES7 Equus caballus ENSECAG00000013278 I 0.914
ENSCSAG00000010748 Chlorocebus sabaeus ENSCSAG00000010748 I 0.914
HES7 Cavia porcellus ENSCPOG00000012913 I 0.914
HES7 Bos taurus ENSBTAG00000012436 I 0.914
HES7 Callithrix jacchus ENSCJAG00000014589 I 0.914
HES7 Felis catus ENSFCAG00000015190 I 0.914
HES7 Loxodonta africana ENSLAFG00000002331 I 0.914
HES7 Macaca mulatta ENSMMUG00000019851 I 0.914
HES7 Gorilla gorilla ENSGGOG00000005760 I 0.914
HES7 Myotis lucifugus ENSMLUG00000008014 I 0.914
ENSOARG00000018861 Ovis aries ENSOARG00000018861 I 0.890
ENSAMEG00000002709 Ailuropoda melanoleuca ENSAMEG00000002709 I 0.890