MESP2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000188095 T034338_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MESP2
M04212_2.00		 Homo sapiens
NAMCATATGKYR
YRMCATATGKTN		 SELEX
Yin et al.(2017)
MESP2_eDBD_HT-SELEX		 (Direct) (Direct)
MESP2
M04213_2.00		 Homo sapiens
NAMCAWWTGKYV
BRMCAWWTGKTN		 SELEX
Yin et al.(2017)
MESP2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342392 bHLH 82 136

Links

Other bHLH family TFs
Other Homo sapiens TFs

5 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
MESP2 Pan troglodytes ENSPTRG00000007440 I 0.914
MESP2 Gorilla gorilla ENSGGOG00000005683 I 0.914
ENSMMUP00000004781 Macaca fascicularis ENSMMUP00000004781 I 0.894
MESP2 Macaca mulatta ENSMMUG00000003584 I 0.894
ENSGACG00000014761 Gasterosteus aculeatus ENSGACG00000014761 I 0.859