CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HES5
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000197921
T034341_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HES5
M02809_2.00
Homo sapiens
YGRCACGTGCCD
HGGCACGTGYCR
SELEX
Jolma et al.(2013)
HES5_1
(Direct)
(Direct)
HES5
M02810_2.00
Homo sapiens
YGGCACGTGCCR
YGGCACGTGCCR
SELEX
Jolma et al.(2013)
HES5_2
(Direct)
(Direct)
HES5
M04216_2.00
Homo sapiens
VRCACGTGCC
GGCACGTGYB
SELEX
Yin et al.(2017)
HES5_eDBD_HT-SELEX
(Direct)
(Direct)
HES5
M04217_2.00
Homo sapiens
VRCACGTGCC
GGCACGTGYB
SELEX
Yin et al.(2017)
HES5_eDBD_Methyl-HT-SELEX_1
(Direct)
(Direct)
HES5
M04218_2.00
Homo sapiens
VSACRCKY
RMGYGTSB
SELEX
Yin et al.(2017)
HES5_eDBD_Methyl-HT-SELEX_2
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hes5
M01747_2.00
Mus musculus
NVCRCGYGBN
NVCRCGYGBN
PBM
Weirauch et al.(2014)
pTH5450
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000367714
bHLH
17
73
NRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSK
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
28 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSPANG00000022730
Papio anubis
ENSPANG00000022730
I
0.914
HES5
Otolemur garnettii
ENSOGAG00000030950
I
0.914
ENSOARG00000018071
Ovis aries
ENSOARG00000018071
I
0.914
HES5
Procavia capensis
ENSPCAG00000001025
I
0.914
HES5
Pan troglodytes
ENSPTRG00000024233
I
0.914
HES5
Tursiops truncatus
ENSTTRG00000003782
I
0.914
Hes5
Rattus norvegicus
ENSRNOG00000013850
I
0.914
ENSMMUG00000014688
Macaca mulatta
ENSMMUG00000014688
I
0.914
Hes5
Mus musculus
ENSMUSG00000048001
D
0.914
ENSCSAG00000000715
Chlorocebus sabaeus
ENSCSAG00000000715
I
0.914
ENSCPOG00000027139
Cavia porcellus
ENSCPOG00000027139
I
0.914
HES5
Canis familiaris
ENSCAFG00000019421
I
0.914
HES5
Bos taurus
ENSBTAG00000002483
I
0.914
HES5
Erinaceus europaeus
ENSEEUG00000008377
I
0.914
HES5
Callithrix jacchus
ENSCJAG00000002549
I
0.914
HES5
Gorilla gorilla
ENSGGOG00000010276
I
0.914
ENSSHAG00000014397
Sarcophilus harrisii
ENSSHAG00000014397
I
0.884
ENSMEUG00000013913
Macropus eugenii
ENSMEUG00000013913
I
0.884
HES5
Monodelphis domestica
ENSMODG00000008212
I
0.884
Alligator_sinensis_CCG011591.1
Alligator sinensis
Alligator_sinensis_CCG011591.1
I
0.860
Brh_R011663
Buceros rhinoceros
Brh_R011663
I
0.860
Tal_R007855
Tyto alba
Tal_R007855
I
0.860
Afo_R003314
Aptenodytes forsteri
Afo_R003314
I
0.860
HES5
Meleagris gallopavo
ENSMGAG00000002009
I
0.860
ENSAPLG00000007967
Anas platyrhynchos
ENSAPLG00000007967
I
0.860
HES5
Gallus gallus
ENSGALG00000001141
I
0.860
Aan_R005913
Calypte anna
Aan_R005913
I
0.860
ENSBTAP00000003221-D1
Bos grunniens
ENSBTAP00000003221-D1
I
0.433