CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Hif1a
(
Mus musculus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSMUSG00000021109
T035677_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hif1a
M08750_2.00
Mus musculus
VDACGTGM
KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_MOUSE.H11MO.0.C
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HIF1A
M08049_2.00
Homo sapiens
NBACGTGCNN
NNGCACGTVN
ChIP-seq
Mathelier et al.(2014)
MA1106.1
0.914
1.000
HIF1A
M08713_2.00
Homo sapiens
VDACGTGM
KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_HUMAN.H11MO.0.C
0.914
1.000
HIF1A
M09454_2.00
Homo sapiens
KACGTGMN
NKCACGTM
Misc
Heinz et al.(2010)
MCF7-HIF1a_GSE28352
0.914
1.000
HIF1A
M09807_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q3
0.914
1.000
HIF1A
M09808_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q5
0.914
1.000
HIF1A
M09809_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q6
0.914
1.000
HIF1A
M09810_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q3
0.914
1.000
HIF1A
M09811_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q5
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000106091
bHLH
18
69
RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV
Links
Other
bHLH
family TFs
Other
Mus musculus
TFs
28 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
HIF1A
Homo sapiens
ENSG00000100644
D
0.914
AAO72733
Xenopus laevis
AAO72733
I
0.914
ABF71072
Xenopus laevis
ABF71072
I
0.914
AAI26006
Xenopus laevis
AAI26006
I
0.914
hif1a
Xenopus tropicalis
XB-GENE-946622
I
0.914
HIF1A
Monodelphis domestica
ENSMODG00000008760
I
0.882
ENSSHAG00000012129
Sarcophilus harrisii
ENSSHAG00000012129
I
0.882
ENSLOCG00000010146
Lepisosteus oculatus
ENSLOCG00000010146
I
0.882
ENSAMXG00000019342
Astyanax mexicanus
ENSAMXG00000019342
I
0.858
Cmyd_10008490
Chelonia mydas
Cmyd_10008490
I
0.857
Brh_R012268
Buceros rhinoceros
Brh_R012268
I
0.857
Gfo_R006824
Geospiza fortis
Gfo_R006824
I
0.857
Tal_R011146
Tyto alba
Tal_R011146
I
0.857
Alligator_sinensis_CCG014229.1
Alligator sinensis
Alligator_sinensis_CCG014229.1
I
0.857
Ogr06281
Ophisaurus gracilis
Ogr06281
I
0.857
ENSTNIG00000019821
Tetraodon nigroviridis
ENSTNIG00000019821
I
0.857
ENSAPLG00000002715
Anas platyrhynchos
ENSAPLG00000002715
I
0.857
ENSFALG00000003396
Ficedula albicollis
ENSFALG00000003396
I
0.857
HIF1A
Meleagris gallopavo
ENSMGAG00000013552
I
0.857
Afo_R010338
Aptenodytes forsteri
Afo_R010338
I
0.857
ENSPSIG00000010467
Pelodiscus sinensis
ENSPSIG00000010467
I
0.857
Aan_R001655
Calypte anna
Aan_R001655
I
0.857
HIF1A
Anolis carolinensis
ENSACAG00000016205
I
0.857
HIF1A
Taeniopygia guttata
ENSTGUG00000012978
I
0.857
HIF1A
Gallus gallus
ENSGALG00000011870
I
0.857
ENSORLG00000015698
Oryzias latipes
ENSORLG00000015698
I
0.846
e_gw.35.150.1
Branchiostoma floridae
e_gw.35.150.1
I
0.845
e_gw.35.42.1
Branchiostoma floridae
e_gw.35.42.1
I
0.845