E(spl)m7-HLH (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0002633 T038396_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic segment; extended germ band embryo; germ layer; presumptive embryonic/larval system; and supraesophageal ganglion. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E(spl)m7-HLH
M05942_2.00		 Drosophila melanogaster
GCACGTGCCAM
KTGGCACGTGC		 B1H
Zhu et al.(2011)
HLHm7_SANGER_5_FBgn0002633		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0084334 bHLH 14 69

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

9 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GI24692 Drosophila mojavensis FBgn0147414 I 0.914
GM10299 Drosophila sechellia FBgn0165250 I 0.914
HLHm7 Drosophila yakuba FBgn0082704 I 0.914
GG11458 Drosophila erecta FBgn0103757 I 0.914
HLHm7 Drosophila simulans FBgn0082734 I 0.914
GF16801 Drosophila ananassae FBgn0093822 I 0.914
GK14459 Drosophila willistoni FBgn0216465 I 0.889
GH19458 Drosophila grimshawi FBgn0126923 I 0.886
GJ23909 Drosophila virilis FBgn0211002 I 0.886