aha-1 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00000095 T046268_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity; DNA-binding transcription factor activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cell fate specification; positive regulation of transcription by RNA polymerase II; and social behavior. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anal region; epithelial system; gonadal primordium; nervous system; and vulva. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator) and ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
C25A1.11a bHLH 45 98
C25A1.11b bHLH 45 98

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

51 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
L889_g7644 Steinernema feltiae L889_g7644 N 0.914
L892_g27191 Steinernema scapterisci L892_g27191 N 0.914
L893_g33137 Steinernema glaseri L893_g33137 N 0.914
L898_g24378 Steinernema monticolum L898_g24378 N 0.914
L596_g21289 Steinernema carpocapsae L596_g21289 N 0.914
CBN20344 Caenorhabditis brenneri CBN20344 N 0.914
CBN21788 Caenorhabditis brenneri CBN21788 N 0.914
CJA09659 Caenorhabditis japonica CJA09659 N 0.914
CRE23963 Caenorhabditis remanei CRE23963 N 0.914
NBR_0001408501 Nippostrongylus brasiliensis NBR_0001408501 N 0.889
MhA1_Contig123.frz3.gene102 Meloidogyne hapla MhA1_Contig123.frz3.gene102 N 0.889
HPLM_0001420401 Haemonchus placei HPLM_0001420401 N 0.889
NECAME_01427 Necator americanus NECAME_01427 N 0.889
SPAL_0000484600 Strongyloides papillosus SPAL_0000484600 N 0.889
TCLT_0000380801 Thelazia callipaeda TCLT_0000380801 N 0.889
TCNE_0001271001 Toxocara canis TCNE_0001271001 N 0.889
TELCIR_14024 Teladorsagia circumcincta TELCIR_14024 N 0.889
SVE_0167700 Strongyloides venezuelensis SVE_0167700 N 0.889
SSTP_0000565500 Strongyloides stercoralis SSTP_0000565500 N 0.889
PTRK_0000871700 Parastrongyloides trichosuri PTRK_0000871700 N 0.889
GPUH_0001856701 Gongylonema pulchrum GPUH_0001856701 N 0.889
OESDEN_00417 Oesophagostomum dentatum OESDEN_00417 N 0.889
HCOI00027700 Haemonchus contortus HCOI00027700 N 0.889
ACOC_0000445401 Angiostrongylus costaricensis ACOC_0000445401 N 0.889
ANCCEY_13945 Ancylostoma ceylanicum ANCCEY_13945 N 0.889
ACAC_0000261401 Angiostrongylus cantonensis ACAC_0000261401 N 0.889
ANCCAN_24904 Ancylostoma caninum ANCCAN_24904 N 0.889
EVEC_0000439301 Enterobius vermicularis EVEC_0000439301 N 0.889
ALUE_0000466001 Ascaris lumbricoides ALUE_0000466001 N 0.889
Minc05207 Meloidogyne incognita Minc05207 N 0.889
Minc15071 Meloidogyne incognita Minc15071 N 0.889
ANCDUO_07053 Ancylostoma duodenale ANCDUO_07053 N 0.889
ASIM_0001352101 Anisakis simplex ASIM_0001352101 N 0.889
ASU_08380 Ascaris suum ASU_08380 N 0.889
DICVIV_02602 Dictyocaulus viviparus DICVIV_02602 N 0.889
nRc.2.0.1.g11083 Romanomermis culicivorax nRc.2.0.1.g11083 N 0.877
TTRE_0000251601 Trichuris trichiura TTRE_0000251601 N 0.876
D918_05776 Trichuris suis D918_05776 N 0.876
D917_07015 Trichinella nativa D917_07015 N 0.876
EFV53021 Trichinella spiralis EFV53021 N 0.876
LOAG_08661 Loa loa LOAG_08661 N 0.868
WBGene00237491 Onchocerca volvulus WBGene00237491 N 0.868
nLs.2.1.2.g03389 Litomosoides sigmodontis nLs.2.1.2.g03389 N 0.868
DME_0000607201 Dracunculus medinensis DME_0000607201 N 0.868
Bm2359 Brugia malayi Bm2359 N 0.868
nAv.1.0.1.g02714 Acanthocheilonema viteae nAv.1.0.1.g02714 N 0.868
nDi.2.2.2.g01364 Dirofilaria immitis nDi.2.2.2.g01364 N 0.868
OFLC_0000335001 Onchocerca flexuosa OFLC_0000335001 N 0.868
nOo.2.0.1.g07016 Onchocerca ochengi nOo.2.0.1.g07016 N 0.868
RSKR_0000723700 Rhabditophanes kr3021 RSKR_0000723700 N 0.846