| NCBI Gene Info:Enables protein heterodimerization activity and sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of programmed cell death; regulation of axon extension involved in axon guidance; and regulation of oviposition. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including AB lineage cell; P1; P10; nerve ring; and neurons. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1); ASCL3 (achaete-scute family bHLH transcription factor 3); and ASCL4 (achaete-scute family bHLH transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022] |