hlh-10 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00001954 T046278_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables protein heterodimerization activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in neurons. Orthologous to several human genes including MSC (musculin) and TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
hlh-10
M00930_2.00		 Caenorhabditis elegans
CATATATG
CATATATG		 PBM
Grove et al.(2009)
HLH10		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00930_2.00 bHLH 90 141

DNA Binding Domains

Protein ID Domain From To Sequence
ZK682.4 bHLH 122 173

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

1 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CJA14004 Caenorhabditis japonica CJA14004 I 0.870