CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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hlh-30
(
Caenorhabditis elegans
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
WBGene00020930
T046306_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to bacterium; determination of adult lifespan; and positive regulation of macromolecule metabolic process. Acts upstream of or within positive regulation of plasma membrane repair and positive regulation of xenophagy. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; nervous system; rectal valve cell; reproductive system; and somatic cell. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor) and TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
hlh-30
M00937_2.00
Caenorhabditis elegans
WCACGTGA
TCACGTGW
PBM
Grove et al.(2009)
HLH30
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00937_2.00
bHLH
264
317
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
W02C12.3a.1
bHLH
238
291
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3a.2
bHLH
238
291
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3b
bHLH
239
292
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3c
bHLH
264
317
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3d
bHLH
204
257
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3e
bHLH
179
232
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3f
bHLH
213
266
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3g.1
bHLH
238
291
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3g.2
bHLH
238
291
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3h.1
bHLH
101
154
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3h.2
bHLH
101
154
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
W02C12.3h.3
bHLH
101
154
KKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQ
Links
Other
bHLH
family TFs
Other
Caenorhabditis elegans
TFs
38 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
CRE27827
Caenorhabditis remanei
CRE27827
I
0.914
CBG24924
Caenorhabditis briggsae
CBG24924
I
0.914
CBN07317
Caenorhabditis brenneri
CBN07317
I
0.914
CBG05364
Caenorhabditis briggsae
CBG05364
I
0.914
MhA1_Contig2854.frz3.gene1
Meloidogyne hapla
MhA1_Contig2854.frz3.gene1
I
0.889
RSKR_0000797400
Rhabditophanes kr3021
RSKR_0000797400
I
0.889
maker-nMf.1.1.scaf11370-augustus-gene-0.3
Meloidogyne floridensis
maker-nMf.1.1.scaf11370-augustus-gene-0.3
I
0.889
SVE_0222900
Strongyloides venezuelensis
SVE_0222900
I
0.889
PTRK_0001632300
Parastrongyloides trichosuri
PTRK_0001632300
I
0.889
SSTP_0000449500
Strongyloides stercoralis
SSTP_0000449500
I
0.889
Minc08733
Meloidogyne incognita
Minc08733
I
0.889
nAv.1.0.1.g01464
Acanthocheilonema viteae
nAv.1.0.1.g01464
I
0.871
OFLC_0000747401
Onchocerca flexuosa
OFLC_0000747401
I
0.871
nOo.2.0.1.g06941
Onchocerca ochengi
nOo.2.0.1.g06941
I
0.871
Bm6133
Brugia malayi
Bm6133
I
0.871
WUBG_15170
Wuchereria bancrofti
WUBG_15170
I
0.871
EEL_0001011701
Elaeophora elaphi
EEL_0001011701
I
0.871
nDi.2.2.2.g10686
Dirofilaria immitis
nDi.2.2.2.g10686
I
0.871
nLs.2.1.2.g08330
Litomosoides sigmodontis
nLs.2.1.2.g08330
I
0.871
WBGene00240746
Onchocerca volvulus
WBGene00240746
I
0.871
TCLT_0000727601
Thelazia callipaeda
TCLT_0000727601
I
0.871
BXY_0064000
Bursaphelenchus xylophilus
BXY_0064000
I
0.865
scaffold257-EXSNAP2012.8
Pristionchus exspectatus
scaffold257-EXSNAP2012.8
I
0.846
PEQ_0000740201
Parascaris equorum
PEQ_0000740201
I
0.846
OESDEN_00871
Oesophagostomum dentatum
OESDEN_00871
I
0.846
L889_g31943
Steinernema feltiae
L889_g31943
I
0.846
ASIM_0001200001
Anisakis simplex
ASIM_0001200001
I
0.846
ANCCEY_12664
Ancylostoma ceylanicum
ANCCEY_12664
I
0.846
ACOC_0000571601
Angiostrongylus costaricensis
ACOC_0000571601
I
0.846
ACAC_0001364601
Angiostrongylus cantonensis
ACAC_0001364601
I
0.846
DICVIV_03673
Dictyocaulus viviparus
DICVIV_03673
I
0.846
DME_0000936301
Dracunculus medinensis
DME_0000936301
I
0.846
L898_g15395
Steinernema monticolum
L898_g15395
I
0.846
L893_g28705
Steinernema glaseri
L893_g28705
I
0.846
L892_g6408
Steinernema scapterisci
L892_g6408
I
0.846
L596_g25887
Steinernema carpocapsae
L596_g25887
I
0.846
NBR_0000419201
Nippostrongylus brasiliensis
NBR_0000419201
I
0.846