CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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DDIT3
(
Homo sapiens
)
bZIP
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00170 (bZIP_1)
IPR011616
ENSG00000175197
T059758_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
DDIT3
M09999_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CHOP10_01
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Ddit3
M08822_2.00
Mus musculus
MTGATGHAAB
VTTDCATCAK
Misc
Kulakovskiy et al.(2013)
DDIT3_MOUSE.H11MO.0.C
0.890
0.921
Ddit3
M09492_2.00
Mus musculus
MTGATGHAAB
VTTDCATCAK
Misc
Heinz et al.(2010)
MEF-Chop_GSE35681
0.890
0.921
For this family, TFs with SR scores >
0.782
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000340671
bZIP
97
159
EDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRAL
ENSP00000447188
bZIP
97
159
EDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRAL
ENSP00000447803
bZIP
120
182
EDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRAL
ENSP00000448665
bZIP
120
182
EDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRAL
ENSP00000481270
bZIP
96
158
EDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRAL
Links
Other
bZIP
family TFs
Other
Homo sapiens
TFs
28 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
DDIT3
Macaca mulatta
ENSMMUG00000011286
I
1.000
DDIT3
Gorilla gorilla
ENSGGOG00000001987
I
1.000
ENSPANG00000024001
Papio anubis
ENSPANG00000024001
I
1.000
DDIT3
Pan troglodytes
ENSPTRG00000022781
I
1.000
ENSP00000340671
Macaca fascicularis
ENSP00000340671
I
1.000
ENSNLEG00000017291
Nomascus leucogenys
ENSNLEG00000017291
I
1.000
ENSCSAG00000004816
Chlorocebus sabaeus
ENSCSAG00000004816
I
1.000
ENSPPYG00000004692
Pongo abelii
ENSPPYG00000004692
I
0.994
DDIT3
Microcebus murinus
ENSMICG00000005434
I
0.991
ENSSSCG00000022482
Sus scrofa
ENSSSCG00000022482
I
0.978
DDIT3
Callithrix jacchus
ENSCJAG00000007243
I
0.956
DDIT3
Bos taurus
ENSBTAG00000031544
I
0.911
ENSP00000340671-D1
Bos grunniens
ENSP00000340671-D1
I
0.911
DDIT3
Tupaia belangeri
ENSTBEG00000000521
I
0.911
Ddit3
Mus musculus
ENSMUSG00000025408
D
0.890
DDIT3
Equus caballus
ENSECAG00000020535
I
0.889
ENSOARG00000006500
Ovis aries
ENSOARG00000006500
I
0.889
DDIT3
Dasypus novemcinctus
ENSDNOG00000017504
I
0.883
DDIT3
Ochotona princeps
ENSOPRG00000006529
I
0.881
DDIT3
Sorex araneus
ENSSARG00000002536
I
0.880
DDIT3
Erinaceus europaeus
ENSEEUG00000003634
I
0.875
DDIT3
Procavia capensis
ENSPCAG00000016158
I
0.861
DDIT3
Loxodonta africana
ENSLAFG00000030970
I
0.839
DDIT3
Otolemur garnettii
ENSOGAG00000005231
I
0.832
ENSSTOG00000019858
Ictidomys tridecemlineatus
ENSSTOG00000019858
I
0.822
DDIT3
Myotis lucifugus
ENSMLUG00000001055
I
0.821
DDIT3
Pteropus vampyrus
ENSPVAG00000012114
I
0.815