ZNF140 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000196387 T095299_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF140
M04621_2.00		 Homo sapiens
DRCAATTCCGCTCN
NGAGCGGAATTGYH		 SELEX
Yin et al.(2017)
ZNF140_eDBD_HT-SELEX		 (Direct) (Direct)
ZNF140
M04622_2.00		 Homo sapiens
NRCAATTCCGCTCV
BGAGCGGAATTGYN		 SELEX
Yin et al.(2017)
ZNF140_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
ZNF140
M08372_2.00		 Homo sapiens
CAATTCYGCYCHNNNNNNNNNNNB
VNNNNNNNNNNNDGRGCRGAATTG		 ChIP-seq
Schmitges et al.(2016)
P52738_3-10.RCADE		 (Direct) (Direct)
ZNF140
M08945_2.00		 Homo sapiens
NNNDNYBYWGCAATTCYRCTCCHN
NDGGAGYRGAATTGCWRVRNHNNN		 Misc
Kulakovskiy et al.(2013)
ZN140_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000347755 C2H2 ZF 161 183
ENSP00000347755 C2H2 ZF 189 211
ENSP00000347755 C2H2 ZF 217 239
ENSP00000347755 C2H2 ZF 245 267
ENSP00000347755 C2H2 ZF 273 295
ENSP00000347755 C2H2 ZF 301 323
ENSP00000347755 C2H2 ZF 329 351
ENSP00000347755 C2H2 ZF 357 379
ENSP00000347755 C2H2 ZF 385 407
ENSP00000347755 C2H2 ZF 413 435
ENSP00000445411 C2H2 ZF 58 80
ENSP00000445411 C2H2 ZF 86 108
ENSP00000445411 C2H2 ZF 114 136
ENSP00000445411 C2H2 ZF 142 164
ENSP00000445411 C2H2 ZF 170 192
ENSP00000445411 C2H2 ZF 198 220
ENSP00000445411 C2H2 ZF 226 248
ENSP00000445411 C2H2 ZF 254 276
ENSP00000445411 C2H2 ZF 282 304
ENSP00000445411 C2H2 ZF 310 332

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

28 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ZNF140 Gorilla gorilla ENSGGOG00000026442 I 0.825
ENSNLEG00000012479 Nomascus leucogenys ENSNLEG00000012479 I 0.825
ENSPPYG00000005153 Pongo abelii ENSPPYG00000005153 I 0.825
ZNF140 Pan troglodytes ENSPTRG00000023960 I 0.825
ENSCSAG00000001815 Chlorocebus sabaeus ENSCSAG00000001815 I 0.821
ENSPANG00000001812 Papio anubis ENSPANG00000001812 I 0.821
ENSP00000347755 Macaca fascicularis ENSP00000347755 I 0.821
ZNF140 Macaca mulatta ENSMMUG00000003150 I 0.821
ZNF140 Callithrix jacchus ENSCJAG00000013104 I 0.819
ZNF140 Otolemur garnettii ENSOGAG00000030665 I 0.810
ENSAMEG00000013369 Ailuropoda melanoleuca ENSAMEG00000013369 I 0.807
ENSMPUG00000002714 Mustela putorius furo ENSMPUG00000002714 I 0.805
Myotis_brandtii_ZNF140_10005227 Myotis brandtii Myotis_brandtii_ZNF140_10005227 I 0.802
ZNF140 Canis familiaris ENSCAFG00000030275 I 0.802
ZNF140 Bos taurus ENSBTAG00000040072 I 0.801
ENSOARG00000008528 Ovis aries ENSOARG00000008528 I 0.801
ZNF140 Equus caballus ENSECAG00000007427 I 0.800
ZNF140 Felis catus ENSFCAG00000024075 I 0.800
ZNF140 Vicugna pacos ENSVPAG00000011394 I 0.799
ZNF140 Myotis lucifugus ENSMLUG00000009202 I 0.798
ZNF140 Pteropus vampyrus ENSPVAG00000014537 I 0.795
ZNF140 Dasypus novemcinctus ENSDNOG00000019632 I 0.795
ZNF140 Echinops telfairi ENSETEG00000020180 I 0.795
ZNF140 Procavia capensis ENSPCAG00000014332 I 0.792
ZNF140 Tursiops truncatus ENSTTRG00000004364 I 0.790
ENSSTOG00000014531 Ictidomys tridecemlineatus ENSSTOG00000014531 I 0.784
ZNF140 Sorex araneus ENSSARG00000000083 I 0.774