CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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sug
(
Drosophila melanogaster
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
FBgn0033782
T114504_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to nutrient; negative regulation of transcription by RNA polymerase II; and response to starvation. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including adult fat body; adult insulin secreting cell of pars intercerebralis; embryonic/larval muscle system; embryonic/larval posterior spiracle; and extended germ band embryo. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
sug
M03688_2.00
Drosophila melanogaster
BVCCCCCCRCVDN
NHBGYGGGGGGBV
SELEX
Nitta et al.(2015)
sug_1
(Direct)
(Direct)
sug
M06132_2.00
Drosophila melanogaster
MNKRCCCCCCRSSG
CSSYGGGGGGYMNK
B1H
Zhu et al.(2011)
sug_SANGER_5_FBgn0033782
(Direct)
(Direct)
sug
M06133_2.00
Drosophila melanogaster
VVSMCCCCCCRCRRN
NYYGYGGGGGGKSBB
B1H
Zhu et al.(2011)
sug_SOLEXA_5_FBgn0033782
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0086902
C2H2 ZF
128
153
FVCNWTDCDRVFDTLDALAQHVTQRH
FBpp0086902
C2H2 ZF
163
190
YYCRWRGCQRSERGFNARYKMLVHTRTH
FBpp0086902
C2H2 ZF
196
218
HRCHLCEKSFSRAENLKIHIRSH
FBpp0086902
C2H2 ZF
224
248
YKCSFEGCQKAYSNSSDRFKHTRTH
FBpp0086902
C2H2 ZF
254
280
YMCKVAGCQKRYTDPSSLRKHVKTFKH
FBpp0304310
C2H2 ZF
66
91
FVCNWTDCDRVFDTLDALAQHVTQRH
FBpp0304310
C2H2 ZF
101
128
YYCRWRGCQRSERGFNARYKMLVHTRTH
FBpp0304310
C2H2 ZF
134
156
HRCHLCEKSFSRAENLKIHIRSH
FBpp0304310
C2H2 ZF
162
186
YKCSFEGCQKAYSNSSDRFKHTRTH
FBpp0304310
C2H2 ZF
192
222
YMCKVAGCQKRYTDPSSLRKHVKTFKHSIHL
Links
Other
C2H2 ZF
family TFs
Other
Drosophila melanogaster
TFs
12 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
GD10932
Drosophila simulans
FBgn0182695
I
0.827
GG20347
Drosophila erecta
FBgn0112538
I
0.827
GE12506
Drosophila yakuba
FBgn0230244
I
0.818
GM21434
Drosophila sechellia
FBgn0176315
I
0.781
GF12930
Drosophila ananassae
FBgn0089964
I
0.779
GK20769
Drosophila willistoni
FBgn0222765
I
0.767
GJ21228
Drosophila virilis
FBgn0208361
I
0.765
GI19975
Drosophila mojavensis
FBgn0142712
I
0.765
GH20305
Drosophila grimshawi
FBgn0127769
I
0.765
GA17730
Drosophila pseudoobscura
FBgn0077740
I
0.759
GL17162
Drosophila persimilis
FBgn0154766
I
0.759