vfl (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0259789 T117211_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables chromatin loop anchoring activity; nucleosome binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of gastrulation; positive regulation of macromolecule metabolic process; and positive regulation of neuroblast proliferation. Located in nucleoplasm. Colocalizes with chromatin. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; ovary; presumptive embryonic/larval system; and wing disc. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
vfl
M06166_2.00		 Drosophila melanogaster
CTACCTGM
KCAGGTAG		 B1H
Zhu et al.(2011)
vfl_SANGER_5_FBgn0259789		 (Direct) (Direct)
vfl
M06167_2.00		 Drosophila melanogaster
NNNCTACCTGMNNNN
NNNNKCAGGTAGNNN		 B1H
Zhu et al.(2011)
vfl_SOLEXA_5_FBgn0259789		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0074576 C2H2 ZF 1326 1349
FBpp0074576 C2H2 ZF 1355 1377
FBpp0074576 C2H2 ZF 1384 1407
FBpp0074576 C2H2 ZF 1413 1435
FBpp0074577 C2H2 ZF 1326 1349
FBpp0074577 C2H2 ZF 1355 1377
FBpp0074577 C2H2 ZF 1384 1407
FBpp0074577 C2H2 ZF 1413 1435
FBpp0311265 C2H2 ZF 1326 1349
FBpp0311265 C2H2 ZF 1355 1377
FBpp0311265 C2H2 ZF 1384 1407
FBpp0311265 C2H2 ZF 1413 1435

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

9 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GE17353 Drosophila yakuba FBgn0234824 I 0.827
GA22861 Drosophila pseudoobscura FBgn0244263 I 0.827
GK16344 Drosophila willistoni FBgn0218346 I 0.827
GM22706 Drosophila sechellia FBgn0177576 I 0.827
GG18021 Drosophila erecta FBgn0110239 I 0.827
GI15246 Drosophila mojavensis FBgn0137995 I 0.827
GL12930 Drosophila persimilis FBgn0150536 I 0.827
GF20463 Drosophila ananassae FBgn0097470 I 0.822