eor-1 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00001324 T131555_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in several structures, including epithelial system; gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human MYNN (myoneurin); ZBTB24 (zinc finger and BTB domain containing 24); and ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
eor-1
M01865_2.00		 Caenorhabditis elegans
VNYCCCYN
NRGGGRNB		 PBM
Weirauch et al.(2014)
pTH9118		 (Direct) (Direct)
eor-1
M08102_2.00		 Caenorhabditis elegans
TBTCTBYBTCTCTHN
NDAGAGAVRVAGAVA		 ChIP-seq
Mathelier et al.(2014)
MA0543.1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01865_2.00 C2H2 ZF 51 73
M01865_2.00 C2H2 ZF 81 103
M01865_2.00 C2H2 ZF 109 131
M01865_2.00 C2H2 ZF 136 160
M01865_2.00 C2H2 ZF 166 188
M01865_2.00 C2H2 ZF 194 217

DNA Binding Domains

Protein ID Domain From To Sequence
R11E3.6a C2H2 ZF 509 531
R11E3.6a C2H2 ZF 539 561
R11E3.6a C2H2 ZF 567 589
R11E3.6a C2H2 ZF 594 618
R11E3.6a C2H2 ZF 624 646
R11E3.6a C2H2 ZF 652 675
R11E3.6b C2H2 ZF 6 28
R11E3.6b C2H2 ZF 34 57

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

2 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nLs.2.1.2.g05893 Litomosoides sigmodontis nLs.2.1.2.g05893 N 0.787
OFLC_0001415501 Onchocerca flexuosa OFLC_0001415501 N 0.781