egrh-2 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00043705 T131646_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
egrh-1
M00622_2.00 		Caenorhabditis elegans
CSCCCMCR
YGKGGGSG		 PBM
Narasimhan et al.(2015)
pTH9317 		0.783 0.855
sr
M06072_2.00 		Drosophila melanogaster
HVMCGCCCMCVYMH
DKRBGKGGGCGKBD		 B1H
Zhu et al.(2011)
sr_SANGER_5_FBgn0003499 		0.767 0.812
sr
M06073_2.00 		Drosophila melanogaster
NNMCRCCCMCVHNN
NNDBGKGGGYGKNN		 B1H
Zhu et al.(2011)
sr_SOLEXA_5_FBgn0003499 		0.767 0.812
Egr1
M01864_2.00 		Mus musculus
CCCMCGYNN
NNRCGKGGG		 PBM
Weirauch et al.(2014)
pTH5337 		0.757 0.841
Egr1
M00375_2.00 		Mus musculus
NCCYMCDNN
NNHGKRGGN		 PBM
Berger et al.(2006)
Zif268 		0.757 0.841
EGR1
M02883_2.00 		Homo sapiens
NMCGCCCMCGCANN
NNTGCGKGGGCGKN		 SELEX
Jolma et al.(2013)
EGR1_1 		0.757 0.841
EGR1
M02884_2.00 		Homo sapiens
HMCGCCCACGCAHW
WDTGCGTGGGCGKD		 SELEX
Jolma et al.(2013)
EGR1_2 		0.757 0.841
Egr1
M02932_2.00 		Mus musculus
HHMCGCCCMCBCAHHH
DDDTGVGKGGGCGKDD		 SELEX
Jolma et al.(2013)
Egr1_1 		0.757 0.841
EGR1
M04437_2.00 		Homo sapiens
NNCRCCCMCRCNN
NNGYGKGGGYGNN		 SELEX
Yin et al.(2017)
EGR1_eDBD_HT-SELEX 		0.757 0.841
Egr1
M05860_2.00 		Mus musculus
NNMCRCCCMCGCN
NGCGKGGGYGKNN		 SMiLE-seq
Isakova et al.(2017)
EGR1 		0.757 0.841
EGR1
M07927_2.00 		Homo sapiens
NVBNNNNBCCGCCCMCGCNB
VNGCGKGGGCGGVNNNNVBN		 ChIP-seq
Gerstein et al.(2012)
GM12878_EGR1_HudsonAlpha 		0.757 0.841
EGR1
M07928_2.00 		Homo sapiens
BNCCGCCCMCGCNBB
VVNGCGKGGGCGGNV		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_EGR1_HudsonAlpha 		0.757 0.841
EGR1
M07929_2.00 		Homo sapiens
NNNNNNBNNCCRCCCMCGCN
NGCGKGGGYGGNNVNNNNNN		 ChIP-seq
Gerstein et al.(2012)
K562_EGR1_HudsonAlpha 		0.757 0.841
EGR1
M08882_2.00 		Homo sapiens
BHNCCDCCCMCDCHBNB
VNVDGHGKGGGHGGNDV		 Misc
Kulakovskiy et al.(2013)
EGR1_HUMAN.H11MO.0.A 		0.757 0.841
Egr1
M08996_2.00 		Mus musculus
YYCCRCCCMCGCNB
VNGCGKGGGYGGRR		 Misc
Kulakovskiy et al.(2013)
EGR1_MOUSE.H11MO.0.A 		0.757 0.841
EGR1
M09506_2.00 		Homo sapiens
CRCCCMCRCA
TGYGKGGGYG		 Misc
Heinz et al.(2010)
K562-Egr1_GSE32465 		0.757 0.841
EGR1
M10188_2.00 		Homo sapiens
MCGCCYACGCAW
WTGCGTRGGCGK		 Transfac
Matys et al.(2006)
V$EGR1_01 		0.757 0.841
EGR1
M10189_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_02 		0.757 0.841
EGR1
M10190_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_09 		0.757 0.841
EGR1
M10191_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_11 		0.757 0.841
EGR1
M10192_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_12 		0.757 0.841
EGR1
M10193_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_13 		0.757 0.841
EGR1
M10194_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_15 		0.757 0.841
EGR1
M10195_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_Q3 		0.757 0.841
EGR1
M10196_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$EGR1_Q6 		0.757 0.841
EGR1
M04438_2.00 		Homo sapiens
NHCDCCCMCNYNN
NNRNGKGGGHGDN		 SELEX
Yin et al.(2017)
EGR1_eDBD_Methyl-HT-SELEX 		0.757 0.841
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
Y55F3AM.7a C2H2 ZF 178 202
Y55F3AM.7a C2H2 ZF 208 230
Y55F3AM.7a C2H2 ZF 236 258
Y55F3AM.7b C2H2 ZF 178 202
Y55F3AM.7b C2H2 ZF 208 230
Y55F3AM.7b C2H2 ZF 236 258
Y55F3AM.7c C2H2 ZF 13 37
Y55F3AM.7c C2H2 ZF 43 65
Y55F3AM.7c C2H2 ZF 71 93
Y55F3AM.7d C2H2 ZF 13 37
Y55F3AM.7d C2H2 ZF 43 65
Y55F3AM.7d C2H2 ZF 71 93

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

154 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nDi.2.2.2.g10233 Dirofilaria immitis nDi.2.2.2.g10233 I 0.783
CRE15316 Caenorhabditis remanei CRE15316 I 0.783
nDi.2.2.2.g04849 Dirofilaria immitis nDi.2.2.2.g04849 I 0.783
nOo.2.0.1.g00761 Onchocerca ochengi nOo.2.0.1.g00761 I 0.783
OFLC_0000114001 Onchocerca flexuosa OFLC_0000114001 I 0.783
BTMF_0000380401 Brugia timori BTMF_0000380401 I 0.783
nDi.2.2.2.g01941 Dirofilaria immitis nDi.2.2.2.g01941 I 0.783
nDi.2.2.2.g10231 Dirofilaria immitis nDi.2.2.2.g10231 I 0.783
CJA07724 Caenorhabditis japonica CJA07724 I 0.783
LOAG_00574 Loa loa LOAG_00574 I 0.783
WUBG_00846 Wuchereria bancrofti WUBG_00846 I 0.783
Bm2429 Brugia malayi Bm2429 I 0.783
CBG07600 Caenorhabditis briggsae CBG07600 I 0.783
WBGene00241269 Onchocerca volvulus WBGene00241269 I 0.783
CBN14580 Caenorhabditis brenneri CBN14580 I 0.783
nAv.1.0.1.g06838 Acanthocheilonema viteae nAv.1.0.1.g06838 I 0.783
NBR_0001794801 Nippostrongylus brasiliensis NBR_0001794801 I 0.779
ANCCEY_05459 Ancylostoma ceylanicum ANCCEY_05459 I 0.779
ANCCAN_00201 Ancylostoma caninum ANCCAN_00201 I 0.779
ACOC_0001010801 Angiostrongylus costaricensis ACOC_0001010801 I 0.779
ANCDUO_04687 Ancylostoma duodenale ANCDUO_04687 I 0.779
ASU_03721 Ascaris suum ASU_03721 I 0.779
HCOI01030300 Haemonchus contortus HCOI01030300 I 0.779
DICVIV_09967 Dictyocaulus viviparus DICVIV_09967 I 0.779
HPLM_0000563501 Haemonchus placei HPLM_0000563501 I 0.779
EEL_0000568101 Elaeophora elaphi EEL_0000568101 I 0.779
TCNE_0000904301 Toxocara canis TCNE_0000904301 I 0.779
CBG15303 Caenorhabditis briggsae CBG15303 I 0.779
SVUK_0000950901 Strongylus vulgaris SVUK_0000950901 I 0.779
NECAME_02405 Necator americanus NECAME_02405 I 0.779
OESDEN_04362 Oesophagostomum dentatum OESDEN_04362 I 0.779
SPAL_0001308900 Strongyloides papillosus SPAL_0001308900 I 0.776
RSKR_0000852700 Rhabditophanes kr3021 RSKR_0000852700 I 0.776
SSTP_0000848300 Strongyloides stercoralis SSTP_0000848300 I 0.776
SVE_0359700 Strongyloides venezuelensis SVE_0359700 I 0.776
PTRK_0000739300 Parastrongyloides trichosuri PTRK_0000739300 I 0.776
DME_0000200401 Dracunculus medinensis DME_0000200401 I 0.775
nLs.2.1.2.g05421 Litomosoides sigmodontis nLs.2.1.2.g05421 I 0.772
egr2a Danio rerio ENSDARG00000098502 I 0.769
egr2a Danio rerio ENSDARG00000044098 I 0.769
LCUP004430 Lucilia cuprina LCUP004430 I 0.767
HHAL003881-PA Halyomorpha halys HHAL003881-PA I 0.767
GH15079 Drosophila grimshawi FBgn0122554 I 0.767
sr Drosophila melanogaster FBgn0003499 D 0.767
GG22637 Drosophila erecta FBgn0114808 I 0.767
GD19200 Drosophila simulans FBgn0190705 I 0.767
GA27565 Drosophila pseudoobscura FBgn0248930 I 0.767
AGAP002773 Anopheles gambiae AGAP002773 I 0.767
CpipJ_CPIJ010041 Culex pipiens CpipJ_CPIJ010041 I 0.767
GK11242 Drosophila willistoni FBgn0213253 I 0.767
GJ23272 Drosophila virilis FBgn0210374 I 0.767
GM15276 Drosophila sechellia FBgn0170196 I 0.767
AATE013203 Anopheles atroparvus AATE013203 I 0.767
GI23713 Drosophila mojavensis FBgn0146438 I 0.767
AMEM006159 Anopheles merus AMEM006159 I 0.767
MDOA011652 Musca domestica MDOA011652 I 0.767
ASTEI00025 Anopheles stephensi ASTEI00025 I 0.767
AFAF001692 Anopheles farauti AFAF001692 I 0.767
SMUV_0000838501 Syphacia muris SMUV_0000838501 I 0.767
SMAR001323 Strigamia maritima SMAR001323 I 0.767
AQUA009765 Anopheles quadriannulatus AQUA009765 I 0.767
CPIJ010041 Culex quinquefasciatus CPIJ010041 I 0.767
AMEC007413 Anopheles melas AMEC007413 I 0.767
AFUN008124 Anopheles funestus AFUN008124 I 0.767
SPU_015358 Strongylocentrotus purpuratus SPU_015358 I 0.766
ENSLACG00000013087 Latimeria chalumnae ENSLACG00000013087 I 0.766
MCOS_0000604201 Mesocestoides corti MCOS_0000604201 I 0.765
GPUH_0001765101 Gongylonema pulchrum GPUH_0001765101 I 0.763
tetur09g02570 Tetranychus urticae tetur09g02570 I 0.763
TC004846 Tribolium castaneum TC004846 I 0.763
GPUH_0001720001 Gongylonema pulchrum GPUH_0001720001 I 0.763
Ocbimv22022722m.g Octopus bimaculoides Ocbimv22022722m.g I 0.763
CLEC002574 Cimex lectularius CLEC002574 I 0.763
BXY_0899900 Bursaphelenchus xylophilus BXY_0899900 I 0.763
SBAD_0001187401 Soboliphyme baturini SBAD_0001187401 I 0.763
YQE_08157 Dendroctonus ponderosae YQE_08157 I 0.763
PPAI005020 Phlebotomus papatasi PPAI005020 I 0.763
PHUM239230 Pediculus humanus PHUM239230 I 0.763
CGI_10022978 Crassostrea gigas CGI_10022978 I 0.763
RPRC014701 Rhodnius prolixus RPRC014701 I 0.763
egr3 Danio rerio ENSDARG00000089156 I 0.759
egr3 Takifugu rubripes ENSTRUG00000002142 I 0.759
ENSPFOG00000009968 Poecilia formosa ENSPFOG00000009968 I 0.759
egr3 Tetraodon nigroviridis ENSTNIG00000010816 I 0.759
L596_g5772 Steinernema carpocapsae L596_g5772 I 0.759
L892_g3913 Steinernema scapterisci L892_g3913 I 0.759
egr3 Oryzias latipes ENSORLG00000010985 I 0.759
ENSONIG00000011752 Oreochromis niloticus ENSONIG00000011752 I 0.759
ENSGMOG00000005595 Gadus morhua ENSGMOG00000005595 I 0.759
egr3 Gasterosteus aculeatus ENSGACG00000010820 I 0.759
ML074240a Mnemiopsis leidyi ML074240a I 0.759
TTRE_0000209701 Trichuris trichiura TTRE_0000209701 I 0.759
ENSXMAG00000001144 Xiphophorus maculatus ENSXMAG00000001144 I 0.759
ENSPFOG00000009991 Poecilia formosa ENSPFOG00000009991 I 0.759
ENSAMXG00000007269 Astyanax mexicanus ENSAMXG00000007269 I 0.759
L898_g4875 Steinernema monticolum L898_g4875 I 0.759
D917_01971 Trichinella nativa D917_01971 I 0.759
D918_01649 Trichuris suis D918_01649 I 0.759
LotgiG89896 Lottia gigantea LotgiG89896 I 0.759
EGR1 Loxodonta africana ENSLAFG00000016505 I 0.757
EGR1 Meleagris gallopavo ENSMGAG00000009526 I 0.757
ENSMEUG00000012133 Macropus eugenii ENSMEUG00000012133 I 0.757
ENSLACG00000005149 Latimeria chalumnae ENSLACG00000005149 I 0.757
ENSFALG00000003413 Ficedula albicollis ENSFALG00000003413 I 0.757
EGR1 Callithrix jacchus ENSCJAG00000006771 I 0.757
EGR1 Cavia porcellus ENSCPOG00000027141 I 0.757
EGR1 Canis familiaris ENSCAFG00000001254 I 0.757
EGR1 Bos taurus ENSBTAG00000010069 I 0.757
ENSAMEG00000016544 Ailuropoda melanoleuca ENSAMEG00000016544 I 0.757
ENSAPLG00000002018 Anas platyrhynchos ENSAPLG00000002018 I 0.757
ENSCSAG00000013111 Chlorocebus sabaeus ENSCSAG00000013111 I 0.757
EGR1 Dasypus novemcinctus ENSDNOG00000034151 I 0.757
EGR1 Homo sapiens ENSG00000120738 D 0.757
EGR1 Gallus gallus ENSGALG00000007669 I 0.757
EGR1 Felis catus ENSFCAG00000025420 I 0.757
EGR1 Microcebus murinus ENSMICG00000012986 I 0.757
EGR1 Equus caballus ENSECAG00000014338 I 0.757
EGR1 Echinops telfairi ENSETEG00000017735 I 0.757
EGR1 Gorilla gorilla ENSGGOG00000008122 I 0.757
ENSMPUG00000009343 Mustela putorius furo ENSMPUG00000009343 I 0.757
AAT71995 Xenopus tropicalis AAT71995 I 0.757
Pvit_11315 Pogona vitticeps Pvit_11315 I 0.757
Ogr18097 Ophisaurus gracilis Ogr18097 I 0.757
EGR1 Taeniopygia guttata ENSTGUG00000000003 I 0.757
ENSSTOG00000028129 Ictidomys tridecemlineatus ENSSTOG00000028129 I 0.757
egr1 Xenopus tropicalis XB-GENE-853412 I 0.757
egr1.S Xenopus laevis XB-GENE-6252570 I 0.757
Myotis_brandtii_EGR1_10027790 Myotis brandtii Myotis_brandtii_EGR1_10027790 I 0.757
ENSMMUP00000023682 Macaca fascicularis ENSMMUP00000023682 I 0.757
ENSTSYG00000011659 Tarsius syrichta ENSTSYG00000011659 I 0.757
EGR1 Tursiops truncatus ENSTTRG00000005503 I 0.757
Aan_R011027 Calypte anna Aan_R011027 I 0.757
Afo_R012195 Aptenodytes forsteri Afo_R012195 I 0.757
ENSBTAP00000013284-D1 Bos grunniens ENSBTAP00000013284-D1 I 0.757
Cmyd_10006466 Chelonia mydas Cmyd_10006466 I 0.757
EGR1 Myotis lucifugus ENSMLUG00000016841 I 0.757
egr1.L Xenopus laevis XB-GENE-853419 I 0.757
EGR1 Otolemur garnettii ENSOGAG00000033961 I 0.757
ENSPANG00000012366 Papio anubis ENSPANG00000012366 I 0.757
EGR1 Oryctolagus cuniculus ENSOCUG00000008439 I 0.757
ENSNLEG00000008963 Nomascus leucogenys ENSNLEG00000008963 I 0.757
EGR1 Macaca mulatta ENSMMUG00000018025 I 0.757
Egr1 Mus musculus ENSMUSG00000038418 D 0.757
EGR1 Sus scrofa ENSSSCG00000014336 I 0.757
EGR1 Procavia capensis ENSPCAG00000010699 I 0.757
Egr1 Rattus norvegicus ENSRNOG00000019422 I 0.757
ENSSHAG00000012359 Sarcophilus harrisii ENSSHAG00000012359 I 0.757
EGR1 Pteropus vampyrus ENSPVAG00000008351 I 0.757
ENSPSIG00000016357 Pelodiscus sinensis ENSPSIG00000016357 I 0.757
PXEA_0003161501 Protopolystoma xenopodis PXEA_0003161501 I 0.756
EGR2 Gasterosteus aculeatus ENSGACG00000011142 I 0.756
L889_g30195 Steinernema feltiae L889_g30195 I 0.756
L893_g26806 Steinernema glaseri L893_g26806 I 0.756