dnmt1 (Danio rerio)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSDARG00000030756 T167913_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates. Involved in DNA methylation and negative regulation of gene expression. Acts upstream of or within several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and tail bud. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
DNMT1
M01913_2.00 		Homo sapiens
NNNNNCGGNN
NNCCGNNNNN		 PBM
Weirauch et al.(2014)
pTH7029 		0.787 0.787
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000013243 CxxC 524 570
ENSDARP00000073430 CxxC 524 570
ENSDARP00000108456 CxxC 529 575

Links

Other CxxC family TFs
Other Danio rerio TFs

84 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMXG00000012182 Astyanax mexicanus ENSAMXG00000012182 I 0.957
ENSGMOG00000003491 Gadus morhua ENSGMOG00000003491 I 0.872
ENSPFOG00000005624 Poecilia formosa ENSPFOG00000005624 I 0.872
ENSXMAG00000018063 Xiphophorus maculatus ENSXMAG00000018063 I 0.872
dnmt1 Tetraodon nigroviridis ENSTNIG00000018567 I 0.830
dnmt1 Gasterosteus aculeatus ENSGACG00000013741 I 0.830
dnmt1 Takifugu rubripes ENSTRUG00000008132 I 0.830
dnmt1 Oryzias latipes ENSORLG00000005582 I 0.830
ENSLOCG00000007421 Lepisosteus oculatus ENSLOCG00000007421 I 0.830
GB47348 Apis mellifera GB47348 I 0.809
ENSONIG00000001574 Oreochromis niloticus ENSONIG00000001574 I 0.809
ENSOARG00000015380 Ovis aries ENSOARG00000015380 I 0.787
DNMT1 Procavia capensis ENSPCAG00000011023 I 0.787
ENSOCUG00000008415 Oryctolagus cuniculus ENSOCUG00000008415 I 0.787
ENSPPYG00000009545 Pongo abelii ENSPPYG00000009545 I 0.787
DNMT1 Otolemur garnettii ENSOGAG00000001265 I 0.787
ENSSTOG00000010841 Ictidomys tridecemlineatus ENSSTOG00000010841 I 0.787
LotgiG171288 Lottia gigantea LotgiG171288 I 0.787
ENSP00000352516-D1 Bos grunniens ENSP00000352516-D1 I 0.787
ENSP00000352516 Macaca fascicularis ENSP00000352516 I 0.787
Myotis_brandtii_DNMT1_10007965 Myotis brandtii Myotis_brandtii_DNMT1_10007965 I 0.787
GB48403 Apis mellifera GB48403 I 0.787
DNMT1 Vicugna pacos ENSVPAG00000006117 I 0.787
DNMT1 Pteropus vampyrus ENSPVAG00000003676 I 0.787
DNMT1 Sus scrofa ENSSSCG00000013659 I 0.787
ENSNLEG00000012092 Nomascus leucogenys ENSNLEG00000012092 I 0.787
DNMT1 Tursiops truncatus ENSTTRG00000003178 I 0.787
DNMT1 Pan troglodytes ENSPTRG00000010461 I 0.787
ENSPANG00000001264 Papio anubis ENSPANG00000001264 I 0.787
DNMT1 Gorilla gorilla ENSGGOG00000016574 I 0.787
DNMT1 Equus caballus ENSECAG00000026909 I 0.787
DNMT1 Cavia porcellus ENSCPOG00000019557 I 0.787
DNMT1 Bos taurus ENSBTAG00000002736 I 0.787
DNMT1 Felis catus ENSFCAG00000012246 I 0.787
DNMT1 Homo sapiens ENSG00000130816 D 0.787
DNMT1 Loxodonta africana ENSLAFG00000002818 I 0.787
DNMT1 Echinops telfairi ENSETEG00000012574 I 0.787
DNMT1 Macaca mulatta ENSMMUG00000014604 I 0.787
ENSCSAG00000007378 Chlorocebus sabaeus ENSCSAG00000007378 I 0.787
DNMT1 Callithrix jacchus ENSCJAG00000005794 I 0.787
CapteG160905 Capitella teleta CapteG160905 I 0.787
DNMT1 Myotis lucifugus ENSMLUG00000001347 I 0.787
DNMT1 Microcebus murinus ENSMICG00000010231 I 0.787
DNMT1 Dasypus novemcinctus ENSDNOG00000003313 I 0.766
NV11649 Nasonia vitripennis NV11649 I 0.766
Sakowv30005306m.g Saccoglossus kowalevskii Sakowv30005306m.g I 0.766
Ogr12994 Ophisaurus gracilis Ogr12994 I 0.766
Cflo_12808--XP_001122269.1_APIME Camponotus floridanus Cflo_12808--XP_001122269.1_APIME I 0.766
ENSAMEG00000011823 Ailuropoda melanoleuca ENSAMEG00000011823 I 0.766
DNMT1 Canis familiaris ENSCAFG00000017892 I 0.766
DNMT1 Ochotona princeps ENSOPRG00000007032 I 0.766
ENSOANG00000012255 Ornithorhynchus anatinus ENSOANG00000012255 I 0.766
Dnmt1 Mus musculus ENSMUSG00000004099 I 0.766
ENSMPUG00000006829 Mustela putorius furo ENSMPUG00000006829 I 0.766
Dnmt1 Rattus norvegicus ENSRNOG00000039859 I 0.766
Hsal_00444--XP_001122269.1_APIME Harpegnathos saltator Hsal_00444--XP_001122269.1_APIME N 0.745
ENSMEUG00000012650 Macropus eugenii ENSMEUG00000012650 I 0.745
HelroG116156 Helobdella robusta HelroG116156 I 0.745
Cmyd_10002310 Chelonia mydas Cmyd_10002310 I 0.745
ENSSHAG00000008894 Sarcophilus harrisii ENSSHAG00000008894 I 0.745
DNMT1 Monodelphis domestica ENSMODG00000005463 I 0.745
ENSPSIG00000002916 Pelodiscus sinensis ENSPSIG00000002916 I 0.745
Aan_R006371 Calypte anna Aan_R006371 I 0.723
Aqu1.224590 Amphimedon queenslandica Aqu1.224590 I 0.723
Pvit_03471 Pogona vitticeps Pvit_03471 I 0.723
e_gw.24.105.1 Branchiostoma floridae e_gw.24.105.1 I 0.723
dnmt1 Xenopus tropicalis XB-GENE-965562 I 0.723
LDEC005925 Leptinotarsa decemlineata LDEC005925 N 0.723
DNMT1 Anolis carolinensis ENSACAG00000003948 I 0.723
ENSFALG00000007760 Ficedula albicollis ENSFALG00000007760 I 0.723
Gfo_R002685 Geospiza fortis Gfo_R002685 I 0.723
Afo_R010037 Aptenodytes forsteri Afo_R010037 I 0.723
Alligator_sinensis_CCG017947.1 Alligator sinensis Alligator_sinensis_CCG017947.1 I 0.723
ENSGALG00000028997 Gallus gallus ENSGALG00000028997 I 0.723
SPU_023599 Strongylocentrotus purpuratus SPU_023599 N 0.723
Dnmt1 Dipodomys ordii ENSDORG00000014116 I 0.723
CGI_10021920 Crassostrea gigas CGI_10021920 I 0.723
dnmt1.S Xenopus laevis XB-GENE-17332488 I 0.702
dnmt1.L Xenopus laevis XB-GENE-965566 I 0.702
Aqu1.203581 Amphimedon queenslandica Aqu1.203581 I 0.702
Ocbimv22034501m.g Octopus bimaculoides Ocbimv22034501m.g I 0.702
CLEC007142 Cimex lectularius CLEC007142 I 0.702
HHAL007197-PA Halyomorpha halys HHAL007197-PA I 0.702