|
Kdm2b
(Mus musculus)
CxxC
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
PF02008 (zf-CXXC) |
IPR002857 |
ENSMUSG00000029475 |
T168121_2.00 |
Ensembl (2018-Dec-8) |
Link out |
NCBI Gene Info:The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
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Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
KDM2B
M01911_2.00 |
Homo sapiens |
NNNNNNCGN |
NCGNNNNNN |
PBM
Weirauch et al.(2014)
pTH9191
|
1.000
|
1.000
|
kdm2ba
M01909_2.00 |
Danio rerio |
NNNNCGN |
NCGNNNN |
PBM
Weirauch et al.(2014)
pTH8577
|
0.979
|
0.979
|
FBXL19
M01916_2.00 |
Tetraodon nigroviridis |
NNNNCGNN |
NNCGNNNN |
PBM
Weirauch et al.(2014)
pTH8570
|
0.894
|
0.894
|
A6H8I1_DANRE
M01906_2.00 |
Danio rerio |
CGTACGYA |
TRCGTACG |
PBM
Weirauch et al.(2014)
pTH9257
|
0.851
|
0.851
|
KDM2A
M01915_2.00 |
Meleagris gallopavo |
NNNNYRNNNN |
NNNNYRNNNN |
PBM
Weirauch et al.(2014)
pTH9212
|
0.809
|
0.809
|
BGIBMGA012843
M01907_2.00 |
Bombyx mori |
NNCGCGTANVNN |
NNBNTACGCGNN |
PBM
Weirauch et al.(2014)
pTH9239
|
0.766
|
0.766
|
kdm2aa
M01910_2.00 |
Danio rerio |
NCGNNNNNN |
NNNNNNCGN |
PBM
Weirauch et al.(2014)
pTH8585
|
0.723
|
0.723
|
For this family, TFs with SR scores > 0.700 will likely have a similar motif |