HCM1 (Saccharomyces cerevisiae)
Forkhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00250 (Forkhead) IPR001766 YCR065W T188837_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables mitochondrial transcription factor activity. Involved in several processes, including cellular response to oxidative stress; regulation of transcription, DNA-templated; and spindle pole body organization. Located in chromatin; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Bamforth-Lazarus syndrome; autosomal recessive nonsyndromic deafness 4; blepharophimosis, ptosis, and epicanthus inversus syndrome; eye disease (multiple); and lymphedema-distichiasis syndrome. Orthologous to several human genes including FOXB1 (forkhead box B1); FOXB2 (forkhead box B2); and FOXC1 (forkhead box C1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HCM1
M00044_2.00		 Saccharomyces cerevisiae
NRWHAACAN
NTGTTDWYN		 PBM
Badis et al.(2008)
HCM1_2157		 (Direct) (Direct)
HCM1
M07473_2.00		 Saccharomyces cerevisiae
VWMAACAH
DTGTTKWB		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0317.1		 (Direct) (Direct)
HCM1
M08554_2.00		 Saccharomyces cerevisiae
VWMAACAH
DTGTTKWB		 Misc
DeBoer et al.(2011)
YCR065W_570		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NCU06173
M01992_2.00 		Neurospora crassa
RTAAACAH
DTGTTTAY		 PBM
Weirauch et al.(2014)
pTH8896 		0.694 0.583
For this family, TFs with SR scores > 0.664 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00044_2.00 Forkhead 51 138

DNA Binding Domains

Protein ID Domain From To Sequence
YCR065W Forkhead 109 196

Links

Other Forkhead family TFs
Other Saccharomyces cerevisiae TFs

174 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
1820_Multiple Saccharomyces mikatae 1820_Multiple I 0.843
2649_YCR065W Saccharomyces paradoxus 2649_YCR065W I 0.843
2876_YCR065W Saccharomyces bayanus 2876_YCR065W I 0.840
KUCA_T00001016001 Kuraishia capsulata KUCA_T00001016001 I 0.791
CAGL0J03608g Candida glabrata CAGL0J03608g I 0.781
TPHA_0D03900 Tetrapisispora phaffii TPHA_0D03900 I 0.779
Kpol_1028p47 Vanderwaltozyma polyspora Kpol_1028p47 I 0.778
KNAG_0I02890 Kazachstania naganishii KNAG_0I02890 I 0.769
TDEL_0A07460 Torulaspora delbrueckii TDEL_0A07460 I 0.749
ZBAI_02769 Zygosaccharomyces bailii ZBAI_02769 I 0.734
ZBAI_09018 Zygosaccharomyces bailii ZBAI_09018 I 0.734
ZYRO0D08426g Zygosaccharomyces rouxii ZYRO0D08426g I 0.733
PredSwiss_CON2884.2 Pneumocystis carinii PredSwiss_CON2884.2 I 0.724
PNEG_01242 Pneumocystis murina PNEG_01242 I 0.724
EPUS_04989 Endocarpon pusillum EPUS_04989 I 0.722
RO3G_13161 Rhizopus oryzae RO3G_13161 I 0.720
Pc18g00430 Penicillium chrysogenum Pc18g00430 I 0.719
PMAA_023910 Penicillium marneffei PMAA_023910 I 0.719
PCH_Pc18g00430 Penicillium rubens PCH_Pc18g00430 I 0.719
PDIP_75040 Penicillium digitatum PDIP_75040 I 0.719
PMAA_023910 Talaromyces marneffei PMAA_023910 I 0.719
PITC_013300 Penicillium italicum PITC_013300 I 0.719
PEX1_059580 Penicillium expansum PEX1_059580 I 0.719
PVAR5_5344 Byssochlamys spectabilis PVAR5_5344 I 0.719
U727_00433931341 Penicillium solitum U727_00433931341 I 0.719
AFUA_3G11960 Aspergillus fumigatus CADAFUAG00005312 I 0.719
CADAFLAG00002435 Aspergillus flavus CADAFLAG00002435 I 0.719
ACLA_039840 Aspergillus clavatus CADACLAG00004044 I 0.719
EURHEDRAFT_84089 Aspergillus ruber EURHEDRAFT_84089 I 0.719
CADANGAG00002306 Aspergillus niger CADANGAG00002306 I 0.719
ANIA_02854 Aspergillus nidulans CADANIAG00010236 I 0.719
fgenesh1_pm.00866_#_484 Aspergillus carbonarius fgenesh1_pm.00866_#_484 I 0.719
NFIA_065340 Neosartorya fischeri CADNFIAG00005675 I 0.719
TSTA_032340 Talaromyces stipitatus TSTA_032340 I 0.719
BN7_1544 Wickerhamomyces ciferrii BN7_1544 I 0.718
PAS_chr1-4_0286 Komagataella pastoris PAS_chr1-4_0286 I 0.717
XP_002490404.1 Pichia pastoris XP_002490404.1 I 0.717
gw1.4.1172.1 Mucor circinelloides gw1.4.1172.1 I 0.716
ATEG_04739 Aspergillus terreus CADATEAG00006672 I 0.716
CADAORAG00001350 Aspergillus oryzae CADAORAG00001350 I 0.715
AACERI_AaceriAAR050C Saccharomycetaceae sp ashbya aceri AACERI_AaceriAAR050C I 0.714
AGOS_AAR050C Ashbya gossypii AGOS_AAR050C I 0.714
Ecym_2489 Eremothecium cymbalariae Ecym_2489 I 0.711
SJAG_03143 Schizosaccharomyces japonicus SJAG_03143 I 0.711
Kwal_6278 Kluyveromyces waltii Kwal_6278 I 0.711
PNEG_00623 Pneumocystis murina PNEG_00623 I 0.709
RO3G_04419 Rhizopus oryzae RO3G_04419 I 0.706
CGGC5_1850 Colletotrichum gloeosporioides CGGC5_1850 I 0.705
ML23712a Mnemiopsis leidyi ML23712a I 0.705
CH063_10052 Colletotrichum higginsianum CH063_10052 I 0.705
CSUB01_05644 Colletotrichum sublineola CSUB01_05644 I 0.705
PV07_01813 Cladophialophora immunda PV07_01813 I 0.704
NEPG_01226 Nematocida parisii ertm1 NEPG_01226 I 0.704
A1O5_06245 Cladophialophora psammophila A1O5_06245 I 0.704
PV08_05339 Exophiala spinifera PV08_05339 I 0.704
PV06_03424 Exophiala oligosperma PV06_03424 I 0.704
HMPREF1120_02814 Exophiala dermatitidis HMPREF1120_02814 I 0.704
PV10_08910 Exophiala mesophila PV10_08910 I 0.704
A1O3_01051 Capronia epimyces A1O3_01051 I 0.704
Z519_10766 Cladophialophora bantiana Z519_10766 I 0.704
A1O1_05934 Capronia coronata A1O1_05934 I 0.704
Z518_04151 Rhinocladiella mackenziei Z518_04151 I 0.704
PV05_11650 Exophiala xenobiotica PV05_11650 I 0.704
Z517_08036 Fonsecaea pedrosoi Z517_08036 I 0.704
Cob_10099 Colletotrichum orbiculare Cob_10099 I 0.702
HCBG_07375 Histoplasma capsulatum HCBG_07375 I 0.702
LALA0_S02e07250g Lachancea lanzarotensis LALA0_S02e07250g I 0.702
HMPREF1541_00364 Cyphellophora europaea HMPREF1541_00364 I 0.700
TBLA_0I02350 Tetrapisispora blattae TBLA_0I02350 I 0.700
NERG_01460 Nematocida sp NERG_01460 I 0.699
PABG_02533 Paracoccidioides brasiliensis PABG_02533 I 0.698
PAAG_07203 Paracoccidioides sp lutzii PAAG_07203 I 0.698
BDDG_09123 Blastomyces dermatitidis BDDG_09123 I 0.698
e_gw1.4.1134.1 Mucor circinelloides e_gw1.4.1134.1 I 0.697
A1O9_06637 Exophiala aquamarina A1O9_06637 I 0.697
CTHT_0023230 Chaetomium thermophilum CTHT_0023230 I 0.696
NDAI_0I00410 Naumovozyma dairenensis NDAI_0I00410 I 0.696
PDE_05162 Penicillium oxalicum PDE_05162 I 0.696
KLTH0A06534g Lachancea thermotolerans KLTH0A06534g I 0.696
PV11_07398 Exophiala sideris PV11_07398 I 0.696
KLTH0A06534g Kluyveromyces thermotolerans KLTH0A06534g I 0.696
RO3G_09342 Rhizopus oryzae RO3G_09342 I 0.695
NEUTE1DRAFT_81248 Neurospora tetrasperma NEUTE1DRAFT_81248 I 0.694
MYCTH_2305050 Myceliophthora thermophila MYCTH_2305050 I 0.694
UCRPA7_1691 Togninia minima UCRPA7_1691 I 0.694
THITE_2118774 Thielavia terrestris THITE_2118774 I 0.694
NCU06173 Neurospora crassa NCU06173 D 0.694
fgenesh2_pg.C_scaffold_5000694 Neurospora discreta fgenesh2_pg.C_scaffold_5000694 I 0.694
YALI0_C09185g Yarrowia lipolytica YALI0_C09185g I 0.694
GLRG_00119 Colletotrichum graminicola GLRG_00119 I 0.694
SMAC_05348 Sordaria macrospora SMAC_05348 I 0.694
CHGG_03283 Chaetomium globosum CHGG_03283 I 0.693
PredSwiss_EST794.1 Pneumocystis carinii PredSwiss_EST794.1 I 0.693
PredSwiss_ASS2010_3214.2 Pneumocystis carinii PredSwiss_ASS2010_3214.2 I 0.693
PredSwiss_CON281.1 Pneumocystis carinii PredSwiss_CON281.1 I 0.693
estExt_fgeneshPB_pg.C_260036 Phycomyces blakesleeanus estExt_fgeneshPB_pg.C_260036 I 0.691
HPODL_02749 Ogataea parapolymorpha HPODL_02749 I 0.689
PODANS_7_8160 Podospora anserina PODANS_7_8160 I 0.689
MPH_06970 Macrophomina phaseolina MPH_06970 I 0.688
UCRNP2_7609 Neofusicoccum parvum UCRNP2_7609 I 0.688
NEMVEDRAFT_v1g132285 Nematostella vectensis NEMVEDRAFT_v1g132285 I 0.688
ENSCING00000001086 Ciona intestinalis ENSCING00000001086 I 0.687
csin104676 Clonorchis sinensis csin104676 I 0.686
gw1.4.1133.1 Mucor circinelloides gw1.4.1133.1 I 0.682
estExt_fgeneshPB_pg.C_490005 Phycomyces blakesleeanus estExt_fgeneshPB_pg.C_490005 I 0.681
RO3G_14448 Rhizopus oryzae RO3G_14448 I 0.679
SROB_0001165901 Schistosoma rodhaini SROB_0001165901 I 0.678
SCUD_0000143501 Schistosoma curassoni SCUD_0000143501 I 0.678
SPBR_00216 Sporothrix brasiliensis SPBR_00216 I 0.678
Smp_155010 Schistosoma mansoni Smp_155010 I 0.678
M438DRAFT_10900 Aureobasidium pullulans M438DRAFT_10900 I 0.678
HMPREF1624_05922 Sporothrix schenckii HMPREF1624_05922 I 0.678
FOXP3 Ornithorhynchus anatinus ENSOANG00000013584 I 0.678
AUEXF2481DRAFT_3444 Aureobasidium subglaciale AUEXF2481DRAFT_3444 I 0.678
M437DRAFT_81025 Aureobasidium melanogenum M437DRAFT_81025 I 0.678
RO3G_14601 Rhizopus oryzae RO3G_14601 I 0.678
ENSSHAG00000017137 Sarcophilus harrisii ENSSHAG00000017137 I 0.678
CaO19.4853 Candida albicans CaO19.4853 I 0.676
CD36_09290 Candida dubliniensis CD36_09290 I 0.676
estExt_fgeneshPB_pg.C_20572 Phycomyces blakesleeanus estExt_fgeneshPB_pg.C_20572 I 0.676
CaO19.12316 Candida albicans CaO19.12316 I 0.676
CTRG_03373 Candida tropicalis CTRG_03373 I 0.676
LELG_00412 Lodderomyces elongisporus LELG_00412 I 0.676
TBLA_0F04070 Tetrapisispora blattae TBLA_0F04070 I 0.675
A_02727 Schistosoma haematobium A_02727 I 0.674
GSTUM_00006159001 Tuber melanosporum GSTUM_00006159001 I 0.674
SMRZ_0001806201 Schistosoma margrebowiei SMRZ_0001806201 I 0.674
Foxp3 Mus musculus ENSMUSG00000039521 I 0.673
estExt_fgenesh1_pg.C_11401 Mycosphaerella fijiensis estExt_fgenesh1_pg.C_11401 I 0.673
Foxp3 Rattus norvegicus ENSRNOG00000011702 I 0.673
MYCFIDRAFT_86251 Pseudocercospora fijiensis MYCFIDRAFT_86251 I 0.673
CAOG_01766 Capsaspora owczarzaki CAOG_01766 I 0.673
Scas_Contig720.88 Saccharomyces castellii Scas_Contig720.88 I 0.672
NCAS_0D04530 Naumovozyma castellii NCAS_0D04530 I 0.672
FOXP3 Cavia porcellus ENSCPOG00000006945 I 0.671
FOXP3 Otolemur garnettii ENSOGAG00000029651 I 0.671
gw1.6.897.1 Mucor circinelloides gw1.6.897.1 I 0.671
Sjc_0002220 Schistosoma japonicum Sjc_0002220 I 0.670
EFV60976 Trichinella spiralis EFV60976 I 0.670
D917_02480 Trichinella nativa D917_02480 I 0.670
FPSE_04780 Fusarium pseudograminearum FPSE_04780 I 0.670
FGRRES_06944 Fusarium graminearum FGRRES_06944 I 0.670
ENSCSAG00000012845 Chlorocebus sabaeus ENSCSAG00000012845 I 0.669
FOXP3 Dasypus novemcinctus ENSDNOG00000012826 I 0.669
FOXP3 Felis catus ENSFCAG00000003823 I 0.669
ENSAMEG00000012121 Ailuropoda melanoleuca ENSAMEG00000012121 I 0.669
FOXP3 Bos taurus ENSBTAG00000013279 I 0.669
FOXP3 Callithrix jacchus ENSCJAG00000002813 I 0.669
ENSSTOG00000004416 Ictidomys tridecemlineatus ENSSTOG00000004416 I 0.669
FOXP3 Canis familiaris ENSCAFG00000015934 I 0.669
FOXP3 Homo sapiens ENSG00000049768 D 0.669
ENSNLEG00000008046 Nomascus leucogenys ENSNLEG00000008046 I 0.669
ENSSHAG00000002680 Sarcophilus harrisii ENSSHAG00000002680 I 0.669
ENSMPUG00000014054 Mustela putorius furo ENSMPUG00000014054 I 0.669
ENSOARG00000010278 Ovis aries ENSOARG00000010278 I 0.669
FOXP3 Oryctolagus cuniculus ENSOCUG00000010135 I 0.669
ENSPPYG00000020341 Pongo abelii ENSPPYG00000020341 I 0.669
ENSPANG00000010672 Papio anubis ENSPANG00000010672 I 0.669
FOXP3 Monodelphis domestica ENSMODG00000009847 I 0.669
Myotis_brandtii_FOXP3_10010880 Myotis brandtii Myotis_brandtii_FOXP3_10010880 I 0.669
ENSMEUG00000008944 Macropus eugenii ENSMEUG00000008944 I 0.669
FOXP3 Loxodonta africana ENSLAFG00000003504 I 0.669
FOXP3 Gorilla gorilla ENSGGOG00000000913 I 0.669
FOXP3 Macaca mulatta ENSMMUG00000008624 I 0.669
estExt_fgeneshPB_pg.C_280113 Phycomyces blakesleeanus estExt_fgeneshPB_pg.C_280113 I 0.669
FOXP3 Sus scrofa ENSSSCG00000012300 I 0.669
H311_02609 Anncaliia algerae H311_02609 I 0.668
ENSGMOG00000000758 Gadus morhua ENSGMOG00000000758 I 0.666
e_gw1.8.572.1 Mucor circinelloides e_gw1.8.572.1 I 0.666
T265_10033 Opisthorchis viverrini T265_10033 I 0.666
PNEG_01841 Pneumocystis murina PNEG_01841 I 0.665
UCREL1_4498 Eutypa lata UCREL1_4498 I 0.665
CFIO01_12634 Colletotrichum fioriniae CFIO01_12634 I 0.664
RPRC000133 Rhodnius prolixus RPRC000133 I 0.664