FHL1 (Saccharomyces cerevisiae)
Forkhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00250 (Forkhead) IPR001766 YPR104C T188840_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; transcription coactivator binding activity; and transcription corepressor binding activity. Involved in negative regulation of ribosomal protein gene transcription by RNA polymerase II and positive regulation of ribosomal protein gene transcription by RNA polymerase II. Located in chromatin and nucleolus. Orthologous to human FOXN4 (forkhead box N4) and FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
FHL1
M00046_2.00		 Saccharomyces cerevisiae
NGACGCAM
KTGCGTCN		 PBM
Badis et al.(2008)
FHL1_2086		 (Direct) (Direct)
FHL1
M01543_2.00		 Saccharomyces cerevisiae
NVDCGCRNN
NNYGCGHBN		 PBM
Zhu et al.(2009)
Fhl1		 (Direct) (Direct)
FHL1
M07475_2.00		 Saccharomyces cerevisiae
GACGCAVN
NBTGCGTC		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0295.1		 (Direct) (Direct)
FHL1
M08557_2.00		 Saccharomyces cerevisiae
NNNDDNGACGCAMWNNNNDN
NHNNNNWKTGCGTCNHHNNN		 Misc
DeBoer et al.(2011)
YPR104C_808		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KLLA0_F08206g
M01015_2.00 		Kluyveromyces lactis
NNVRYKCRNN
NNYGMRYBNN		 PBM
Nakagawa et al.(2013)
KLLA0F08206p 		0.701 0.890
AGOS_AEL327W
M01004_2.00 		Ashbya gossypii
NNVRCKCRNN
NNYGMGYBNN		 PBM
Nakagawa et al.(2013)
AEL327Wp 		0.692 0.902
For this family, TFs with SR scores > 0.664 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00046_2.00 Forkhead 51 137
M01543_2.00 Forkhead 461 547

DNA Binding Domains

Protein ID Domain From To Sequence
YPR104C Forkhead 461 547

Links

Other Forkhead family TFs
Other Saccharomyces cerevisiae TFs

32 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
22632_Multiple Saccharomyces mikatae 22632_Multiple I 0.864
23064_YPR104C Saccharomyces paradoxus 23064_YPR104C I 0.864
25921_YPR104C Saccharomyces bayanus 25921_YPR104C I 0.863
NDAI_0A04850 Naumovozyma dairenensis NDAI_0A04850 I 0.843
SKUD_169306 Saccharomyces kudriavzevii SKUD_169306 I 0.831
KAFR_0D04220 Kazachstania africana KAFR_0D04220 I 0.822
TDEL_0C05550 Torulaspora delbrueckii TDEL_0C05550 I 0.807
ZYRO0C17710g Zygosaccharomyces rouxii ZYRO0C17710g I 0.807
Scas_Contig705.31 Saccharomyces castellii Scas_Contig705.31 I 0.806
NCAS_0A11450 Naumovozyma castellii NCAS_0A11450 I 0.806
KNAG_0A07530 Kazachstania naganishii KNAG_0A07530 I 0.802
Kpol_1018p143 Vanderwaltozyma polyspora Kpol_1018p143 I 0.797
ZBAI_05606 Zygosaccharomyces bailii ZBAI_05606 I 0.793
ZBAI_00452 Zygosaccharomyces bailii ZBAI_00452 I 0.793
CAGL0G01782g Candida glabrata CAGL0G01782g I 0.792
TBLA_0C02390 Tetrapisispora blattae TBLA_0C02390 I 0.791
TPHA_0M01760 Tetrapisispora phaffii TPHA_0M01760 I 0.725
KLLA0_F08206g Kluyveromyces lactis KLLA0_F08206g D 0.701
KUCA_T00003332001 Kuraishia capsulata KUCA_T00003332001 I 0.698
Ecym_2615 Eremothecium cymbalariae Ecym_2615 I 0.697
BN7_771 Wickerhamomyces ciferrii BN7_771 I 0.693
AGOS_AEL327W Ashbya gossypii AGOS_AEL327W D 0.692
AACERI_AaceriAEL327W Saccharomycetaceae sp ashbya aceri AACERI_AaceriAEL327W I 0.692
XP_002494105.1 Pichia pastoris XP_002494105.1 I 0.687
PAS_chr4_0980 Komagataella pastoris PAS_chr4_0980 I 0.687
SAKL0B09284g Lachancea kluyveri SAKL0B09284g I 0.685
JL09_g4297 Pichia kudriavzevii JL09_g4297 I 0.685
Kwal_7268 Kluyveromyces waltii Kwal_7268 I 0.684
KLTH0D03036g Lachancea thermotolerans KLTH0D03036g I 0.684
KLTH0D03036g Kluyveromyces thermotolerans KLTH0D03036g I 0.684
LALA0_S08e07316g Lachancea lanzarotensis LALA0_S08e07316g I 0.684
HPODL_04343 Ogataea parapolymorpha HPODL_04343 I 0.679