Grhl1 (Rattus norvegicus)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSRNOG00000054989 T199219_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in epidermis development and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Predicted to be located in nucleoplasm. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GRHL1
M03071_2.00 		Homo sapiens
RACYKGWHNDWCMGGTT
AACCKGWHNDWCMRGTY		 SELEX
Jolma et al.(2013)
GRHL1_1 		0.847 0.847
GRHL1
M03072_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Jolma et al.(2013)
GRHL1_2 		0.847 0.847
GRHL1
M03073_2.00 		Homo sapiens
HWAACCGGTTTD
HAAACCGGTTWD		 SELEX
Jolma et al.(2013)
GRHL1_3 		0.847 0.847
GRHL1
M04887_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_HT-SELEX 		0.847 0.847
GRHL1
M04888_2.00 		Homo sapiens
DAACMKGTTH
DAACMKGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_Methyl-HT-SELEX 		0.847 0.847
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000068887 Grainyhead 135 349

Links

Other Grainyhead family TFs
Other Rattus norvegicus TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSSTOG00000019842 Ictidomys tridecemlineatus ENSSTOG00000019842 I 0.946
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.866
Grhl1 Mus musculus ENSMUSG00000020656 I 0.865
GRHL1 Pteropus vampyrus ENSPVAG00000002002 I 0.865
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.864
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.864
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.861
Myotis_brandtii_GRHL1_10020834 Myotis brandtii Myotis_brandtii_GRHL1_10020834 I 0.860
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.859
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.859
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.859
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.854
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.854
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.854
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.854
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.854
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.854
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.854
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.850
GRHL1 Equus caballus ENSECAG00000015969 I 0.850
GRHL1 Felis catus ENSFCAG00000007856 I 0.850
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.850
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.849
GRHL1 Homo sapiens ENSG00000134317 D 0.847
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.845
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.845
GRHL1 Monodelphis domestica ENSMODG00000014753 I 0.842
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.840
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.837
ENSP00000384209-D1 Bos grunniens ENSP00000384209-D1 I 0.836
GRHL1 Bos taurus ENSBTAG00000007485 I 0.836
GRHL1 Oryctolagus cuniculus ENSOCUG00000017717 I 0.819
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.815
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.815
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.811
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.811
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.811
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.811
Tal_R012680 Tyto alba Tal_R012680 I 0.811
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.811
grhl1.L Xenopus laevis XB-GENE-486580 I 0.807
XP_002938935 Xenopus tropicalis XP_002938935 I 0.802
ENSPMAG00000005876 Petromyzon marinus ENSPMAG00000005876 I 0.797
ENSSTOG00000002434 Ictidomys tridecemlineatus ENSSTOG00000002434 I 0.796
XP_002938936 Xenopus tropicalis XP_002938936 I 0.795
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.791
Ogr04284 Ophisaurus gracilis Ogr04284 I 0.774
grhl1 Danio rerio ENSDARG00000061391 I 0.769
Pvit_14440 Pogona vitticeps Pvit_14440 I 0.760
ENSPSIG00000010930 Pelodiscus sinensis ENSPSIG00000010930 I 0.730
Aan_R015393 Calypte anna Aan_R015393 I 0.729
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.716