POU5F1 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000204531 T238200_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU5F1
M05501_2.00		 Homo sapiens
NNWTATGYWAATKWVB
VBWMATTWRCATAWNN		 SELEX
Yin et al.(2017)
POU5F1_FL_HT-SELEX		 (Direct) (Direct)
POU5F1
M05502_2.00		 Homo sapiens
DTATGCGCATAH
DTATGCGCATAH		 SELEX
Yin et al.(2017)
POU5F1_FL_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU5F1
M05503_2.00		 Homo sapiens
NDWTATGYWAATKARB
VYTMATTWRCATAWHN		 SELEX
Yin et al.(2017)
POU5F1_FL_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU5F1
M05504_2.00		 Homo sapiens
NYDCGCATAATTARB
VYTAATTATGCGHRN		 SELEX
Yin et al.(2017)
POU5F1_FL_Methyl-HT-SELEX_3		 (Direct) (Direct)
POU5F1
M05875_2.00		 Homo sapiens
NDTATGYWAATN
NATTWRCATAHN		 SMiLE-seq
Isakova et al.(2017)
OCT4		 (Direct) (Direct)
POU5F1
M07976_2.00		 Homo sapiens
NYYWTTSWYATGCARAH
DTYTGCATRWSAAWRRN		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_POU5F1_HudsonAlpha		 (Direct) (Direct)
POU5F1
M08141_2.00		 Homo sapiens
DNATGCAAANN
NNTTTGCATNH		 ChIP-seq
Mathelier et al.(2014)
MA1115.1		 (Direct) (Direct)
POU5F1
M09222_2.00		 Homo sapiens
BYWTTSWHATGCARAH
DTYTGCATDWSAAWRV		 Misc
Kulakovskiy et al.(2013)
PO5F1_HUMAN.H11MO.0.A		 (Direct) (Direct)
POU5F1
M10851_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OCT3_Q6		 (Direct) (Direct)
POU5F1
M10852_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU5F1_01		 (Direct) (Direct)
POU5F1
M10853_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU5F1_04		 (Direct) (Direct)
POU5F1
M10854_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU5F1_05		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000259915 POU 141 212
ENSP00000259915 Homeodomain 231 287
ENSP00000389359 POU 1 16
ENSP00000389359 Homeodomain 35 91
ENSP00000425083 POU 1 16
ENSP00000425083 Homeodomain 35 91
ENSP00000425479 POU 1 16
ENSP00000425479 Homeodomain 35 91
ENSP00000475512 POU 1 16
ENSP00000475512 Homeodomain 35 91
ENSP00000475880 POU 1 42
ENSP00000475880 Homeodomain 61 117
ENSP00000481679 POU 141 173
ENSP00000484778 POU 1 42
ENSP00000484778 Homeodomain 61 117

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

10 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POU5F1 Pan troglodytes ENSPTRG00000017953 I 1.000
ENSPPYG00000017210 Pongo abelii ENSPPYG00000017210 I 1.000
ENSNLEG00000005802 Nomascus leucogenys ENSNLEG00000005802 I 1.000
ENSGGOG00000027662 Gorilla gorilla ENSGGOG00000027662 I 1.000
POU5F1 Callithrix jacchus ENSCJAG00000019789 I 0.917
ENSPANG00000015262 Papio anubis ENSPANG00000015262 N 0.848
POU5F1 Macaca mulatta ENSMMUG00000015688 N 0.824
Myotis_brandtii_POU5F1_10022640 Myotis brandtii Myotis_brandtii_POU5F1_10022640 N 0.818
ENSCPOG00000009976 Cavia porcellus ENSCPOG00000009976 N 0.727