Irf7 (Mus musculus)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSMUSG00000025498 T244220_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to other organism; positive regulation of transcription, DNA-templated; and regulation of toll-like receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf7
M02255_2.00		 Mus musculus
DAHNNGAAAN
NTTTCNNDTH		 PBM
Weirauch et al.(2014)
pTH3475		 (Direct) (Direct)
Irf7
M09244_2.00		 Mus musculus
RAAASYRAAW
WTTYRSTTTY		 Misc
Kulakovskiy et al.(2013)
IRF7_MOUSE.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF7
M03337_2.00 		Homo sapiens
HCGAAAVYGAAAVT
ABTTTCRBTTTCGD		 SELEX
Jolma et al.(2013)
IRF7_1 		0.769 0.769
IRF7
M03338_2.00 		Homo sapiens
RAANCGAAAWTCGNTTY
RAANCGAWTTTCGNTTY		 SELEX
Jolma et al.(2013)
IRF7_2 		0.769 0.769
IRF7
M05547_2.00 		Homo sapiens
NCGAAAVYGAAANYN
NRNTTTCRBTTTCGN		 SELEX
Yin et al.(2017)
IRF7_eDBD_HT-SELEX 		0.769 0.769
IRF7
M09238_2.00 		Homo sapiens
RAAASYRAAW
WTTYRSTTTY		 Misc
Kulakovskiy et al.(2013)
IRF7_HUMAN.H11MO.0.C 		0.769 0.769
IRF7
M10894_2.00 		Homo sapiens
NNSGAAWNYGAAANYBDV
BHVRNTTTCRNWTTCSNN		 Transfac
Matys et al.(2006)
V$IRF7_01 		0.769 0.769
IRF7
M05548_2.00 		Homo sapiens
NNGAAARTGAAAVYR
YRBTTTCAYTTTCNN		 SELEX
Yin et al.(2017)
IRF7_eDBD_Methyl-HT-SELEX 		0.769 0.769
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02255_2.00 IRF 10 124

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000026571 IRF 11 125
ENSMUSP00000095565 IRF 11 125
ENSMUSP00000101644 IRF 11 125
ENSMUSP00000121026 IRF 1 67

Links

Other IRF family TFs
Other Mus musculus TFs

26 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Irf7 Rattus norvegicus ENSRNOG00000017414 I 0.894
IRF7 Callithrix jacchus ENSCJAG00000012124 I 0.779
IRF7 Macaca mulatta ENSMMUG00000004014 I 0.769
ENSPANG00000007390 Papio anubis ENSPANG00000007390 I 0.769
IRF7 Gorilla gorilla ENSGGOG00000008341 I 0.769
ENSSTOG00000005711 Ictidomys tridecemlineatus ENSSTOG00000005711 I 0.769
IRF7 Pan troglodytes ENSPTRG00000003126 I 0.769
ENSNLEG00000008419 Nomascus leucogenys ENSNLEG00000008419 I 0.769
IRF7 Homo sapiens ENSG00000185507 D 0.769
Irf7 Dipodomys ordii ENSDORG00000014096 I 0.760
ENSMPUG00000008845 Mustela putorius furo ENSMPUG00000008845 I 0.760
ENSCSAG00000010883 Chlorocebus sabaeus ENSCSAG00000010883 I 0.760
IRF7 Oryctolagus cuniculus ENSOCUG00000002339 I 0.750
ENSAMEG00000010613 Ailuropoda melanoleuca ENSAMEG00000010613 I 0.750
IRF7 Dasypus novemcinctus ENSDNOG00000006293 I 0.740
IRF7 Tursiops truncatus ENSTTRG00000011148 I 0.740
IRF7 Equus caballus ENSECAG00000009744 I 0.740
ENSOARG00000006626 Ovis aries ENSOARG00000006626 I 0.731
IRF7 Sus scrofa ENSSSCG00000012853 I 0.731
IRF7 Otolemur garnettii ENSOGAG00000004986 I 0.731
IRF7 Loxodonta africana ENSLAFG00000032120 I 0.731
IRF7 Bos taurus ENSBTAG00000047680 I 0.721
IRF7 Pteropus vampyrus ENSPVAG00000006873 I 0.721
ENSP00000329411-D1 Bos grunniens ENSP00000329411-D1 I 0.721
IRF7 Procavia capensis ENSPCAG00000010286 I 0.712