Mybl2 (Mus musculus)
Myb/SANT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00249 (Myb_DNA-binding) IPR014778 ENSMUSG00000017861 T269781_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mybl2
M00807_2.00		 Mus musculus
HAACSGHYN
NRDCSGTTD		 PBM
Weirauch et al.(2013)
pTH3712		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MYBL2
M03345_2.00 		Homo sapiens
RDMSGTTAACSGTT
AACSGTTAACSKHY		 SELEX
Jolma et al.(2013)
MYBL2_1 		0.909 1.000
MYBL2
M03346_2.00 		Homo sapiens
RCCGTTAVRACCGTTA
TAACGGTYBTAACGGY		 SELEX
Jolma et al.(2013)
MYBL2_2 		0.909 1.000
MYBL2
M03347_2.00 		Homo sapiens
NNRACCGTTWN
NWAACGGTYNN		 SELEX
Jolma et al.(2013)
MYBL2_3 		0.909 1.000
MYBL2
M03348_2.00 		Homo sapiens
RDCCGTTWAACBGHY
RDCVGTTWAACGGHY		 SELEX
Jolma et al.(2013)
MYBL2_4 		0.909 1.000
MYBL2
M05561_2.00 		Homo sapiens
NWAACSGTYDN
NHRACSGTTWN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_HT-SELEX 		0.909 1.000
MYBL2
M09600_2.00 		Homo sapiens
NHAACNGHYN
NRDCNGTTDN		 Misc
Heinz et al.(2010)
Hela-BMYB_GSE27030 		0.909 1.000
MYBL2
M05562_2.00 		Homo sapiens
NHRACSGTYDN
NHRACSGTYDN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_Methyl-HT-SELEX 		0.909 1.000
For this family, TFs with SR scores > 0.661 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00807_2.00 Myb 17 63
M00807_2.00 Myb 69 115
M00807_2.00 Myb 121 166

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000018005 Myb 31 77
ENSMUSP00000018005 Myb 83 129
ENSMUSP00000018005 Myb 135 180

Links

Other Myb/SANT family TFs
Other Mus musculus TFs

58 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000023992 Papio anubis ENSPANG00000023992 I 0.909
MYBL2 Loxodonta africana ENSLAFG00000006698 I 0.909
MYBL2 Homo sapiens ENSG00000101057 D 0.909
MYBL2 Felis catus ENSFCAG00000011141 I 0.909
MYBL2 Procavia capensis ENSPCAG00000004366 I 0.909
ENSPPYG00000011022 Pongo abelii ENSPPYG00000011022 I 0.909
ENSMMUP00000023843 Macaca fascicularis ENSMMUP00000023843 I 0.909
MYBL2 Tursiops truncatus ENSTTRG00000013493 I 0.909
MYBL2 Pan troglodytes ENSPTRG00000013510 I 0.909
MYBL2 Equus caballus ENSECAG00000005925 I 0.909
MYBL2 Oryctolagus cuniculus ENSOCUG00000005775 I 0.909
MYBL2 Canis familiaris ENSCAFG00000009336 I 0.909
ENSCSAG00000014069 Chlorocebus sabaeus ENSCSAG00000014069 I 0.909
ENSCJAG00000017819 Callithrix jacchus ENSCJAG00000017819 I 0.909
MYBL2 Cavia porcellus ENSCPOG00000020458 I 0.909
ENSSHAG00000005654 Sarcophilus harrisii ENSSHAG00000005654 I 0.900
MYBL2 Monodelphis domestica ENSMODG00000001228 I 0.900
MYBL2 Otolemur garnettii ENSOGAG00000007702 I 0.898
MYBL2 Bos taurus ENSBTAG00000007783 I 0.898
ENSP00000217026-D1 Bos grunniens ENSP00000217026-D1 I 0.898
ENSOARG00000003547 Ovis aries ENSOARG00000003547 I 0.895
Mybl2 Rattus norvegicus ENSRNOG00000007805 I 0.893
ENSMPUG00000017680 Mustela putorius furo ENSMPUG00000017680 I 0.893
MYBL2 Macaca mulatta ENSMMUG00000018137 I 0.889
ENSAMEG00000003831 Ailuropoda melanoleuca ENSAMEG00000003831 I 0.884
MYBL2 Erinaceus europaeus ENSEEUG00000007817 I 0.878
MYBL2 Sus scrofa ENSSSCG00000007366 I 0.878
ENSSTOG00000010149 Ictidomys tridecemlineatus ENSSTOG00000010149 I 0.877
MYBL2 Myotis lucifugus ENSMLUG00000016678 I 0.872
Myotis_brandtii_MYBL2_10025179 Myotis brandtii Myotis_brandtii_MYBL2_10025179 I 0.872
Mybl2 Dipodomys ordii ENSDORG00000006855 I 0.871
Cmyd_10015187 Chelonia mydas Cmyd_10015187 I 0.861
Alligator_sinensis_CCG014289.1 Alligator sinensis Alligator_sinensis_CCG014289.1 I 0.860
ENSPSIG00000016162 Pelodiscus sinensis ENSPSIG00000016162 I 0.860
Brh_R006404 Buceros rhinoceros Brh_R006404 I 0.852
Afo_R009791 Aptenodytes forsteri Afo_R009791 I 0.851
ENSAPLG00000005213 Anas platyrhynchos ENSAPLG00000005213 I 0.851
MYBL2 Gallus gallus ENSGALG00000003503 I 0.851
Gfo_R005427 Geospiza fortis Gfo_R005427 I 0.851
Tal_R007942 Tyto alba Tal_R007942 I 0.851
ENSTGUG00000004426 Taeniopygia guttata ENSTGUG00000004426 I 0.851
Aan_R003280 Calypte anna Aan_R003280 I 0.851
MYBL2 Meleagris gallopavo ENSMGAG00000002972 I 0.835
ENSOANG00000011081 Ornithorhynchus anatinus ENSOANG00000011081 I 0.829
ENSLACG00000018995 Latimeria chalumnae ENSLACG00000018995 I 0.809
ENSFALG00000005745 Ficedula albicollis ENSFALG00000005745 I 0.807
MYBL2 Ochotona princeps ENSOPRG00000009014 I 0.791
ENSCJAG00000031864 Callithrix jacchus ENSCJAG00000031864 I 0.787
Ogr13963 Ophisaurus gracilis Ogr13963 I 0.781
MYBL2 Anolis carolinensis ENSACAG00000002463 I 0.781
Pvit_07752 Pogona vitticeps Pvit_07752 I 0.761
MYBL2 Pteropus vampyrus ENSPVAG00000001218 I 0.757
ENSNLEG00000006566 Nomascus leucogenys ENSNLEG00000006566 I 0.730
ENSLOCG00000001337 Lepisosteus oculatus ENSLOCG00000001337 I 0.728
mybl2 Xenopus tropicalis XB-GENE-982419 I 0.716
mybl2.S Xenopus laevis XB-GENE-982423 I 0.703
S33643 Xenopus laevis S33643 I 0.703
mybl2b Danio rerio ENSDARG00000032264 I 0.679