MYRF (Homo sapiens)
Ndt80/PhoG

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05224 (NDT80_PhoG) IPR007888 ENSG00000124920 T299765_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MYRF
M02385_2.00		 Homo sapiens
TGGTACCA
TGGTACCA		 PBM
Weirauch et al.(2014)
pTH9310		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Myrf
M02386_2.00 		Mus musculus
NNGTRHSNNN
NNNSDYACNN		 PBM
Weirauch et al.(2014)
pTH8554 		1.000 1.000
myrf
M02384_2.00 		Danio rerio
TGGTACCR
YGGTACCA		 PBM
Weirauch et al.(2014)
pTH8654 		0.825 0.825
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02385_2.00 Ndt80/PhoG 51 198

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000265460 Ndt80/PhoG 384 531
ENSP00000278836 Ndt80/PhoG 393 540

Links

Other Ndt80/PhoG family TFs
Other Homo sapiens TFs

62 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
MYRF Sus scrofa ENSSSCG00000013078 I 1.000
MYRF Gorilla gorilla ENSGGOG00000012529 I 1.000
MYRF Pan troglodytes ENSPTRG00000003749 I 1.000
MYRF Pteropus vampyrus ENSPVAG00000012342 I 1.000
Myrf Rattus norvegicus ENSRNOG00000028274 I 1.000
MYRF Canis familiaris ENSCAFG00000016062 I 1.000
ENSAMEG00000016669 Ailuropoda melanoleuca ENSAMEG00000016669 I 1.000
Myrf Mus musculus ENSMUSG00000036098 D 1.000
MYRF Felis catus ENSFCAG00000013683 I 1.000
Myrf Dipodomys ordii ENSDORG00000002029 I 1.000
ENSPANG00000013413 Papio anubis ENSPANG00000013413 I 0.993
ENSMPUG00000014126 Mustela putorius furo ENSMPUG00000014126 I 0.993
MYRF Macaca mulatta ENSMMUG00000006655 I 0.993
MYRF Otolemur garnettii ENSOGAG00000010786 I 0.993
ENSPPYG00000003180 Pongo abelii ENSPPYG00000003180 I 0.993
ENSSTOG00000000529 Ictidomys tridecemlineatus ENSSTOG00000000529 I 0.993
MYRF Callithrix jacchus ENSCJAG00000019218 I 0.993
MYRF Oryctolagus cuniculus ENSOCUG00000003269 I 0.993
ENSCSAG00000006452 Chlorocebus sabaeus ENSCSAG00000006452 I 0.993
MYRF Bos taurus ENSBTAG00000006990 I 0.986
MYRF Dasypus novemcinctus ENSDNOG00000005294 I 0.986
MYRF Cavia porcellus ENSCPOG00000013543 I 0.979
Alligator_sinensis_CCG012901.1 Alligator sinensis Alligator_sinensis_CCG012901.1 I 0.965
ENSBTAP00000009187-D1 Bos grunniens ENSBTAP00000009187-D1 I 0.958
MYRF Equus caballus ENSECAG00000021799 I 0.958
ENSP00000278836 Macaca fascicularis ENSP00000278836 I 0.951
MYRF Procavia capensis ENSPCAG00000017079 I 0.930
ENSOARG00000013482 Ovis aries ENSOARG00000013482 I 0.930
MYRF Myotis lucifugus ENSMLUG00000010326 I 0.930
ENSPSIG00000015590 Pelodiscus sinensis ENSPSIG00000015590 I 0.923
ENSFALG00000011806 Ficedula albicollis ENSFALG00000011806 I 0.916
ENSTGUG00000006600 Taeniopygia guttata ENSTGUG00000006600 I 0.916
Gfo_R011942 Geospiza fortis Gfo_R011942 I 0.916
ENSAPLG00000006054 Anas platyrhynchos ENSAPLG00000006054 I 0.916
MYRF Meleagris gallopavo ENSMGAG00000004733 I 0.916
ENSGALG00000020522 Gallus gallus ENSGALG00000020522 I 0.916
ENSSHAG00000002443 Sarcophilus harrisii ENSSHAG00000002443 I 0.888
Brh_R007745 Buceros rhinoceros Brh_R007745 I 0.888
Aan_R010750 Calypte anna Aan_R010750 I 0.887
Afo_R010549 Aptenodytes forsteri Afo_R010549 I 0.887
Tal_R006175 Tyto alba Tal_R006175 I 0.887
ENSLACG00000016455 Latimeria chalumnae ENSLACG00000016455 I 0.874
Pvit_15884 Pogona vitticeps Pvit_15884 I 0.874
ENSMEUG00000004200 Macropus eugenii ENSMEUG00000004200 I 0.860
ENSNLEG00000003069 Nomascus leucogenys ENSNLEG00000003069 I 0.846
myrf Xenopus tropicalis XB-GENE-1020968 I 0.839
ENSAMXG00000015793 Astyanax mexicanus ENSAMXG00000015793 I 0.839
ENSXMAG00000003748 Xiphophorus maculatus ENSXMAG00000003748 I 0.832
ENSGMOG00000017696 Gadus morhua ENSGMOG00000017696 I 0.832
MYRF Anolis carolinensis ENSACAG00000017691 I 0.825
ENSPFOG00000011050 Poecilia formosa ENSPFOG00000011050 I 0.825
myrf Danio rerio ENSDARG00000078676 D 0.825
MYRF Oryzias latipes ENSORLG00000006459 I 0.818
MYRF Takifugu rubripes ENSTRUG00000005197 I 0.811
ENSONIG00000015523 Oreochromis niloticus ENSONIG00000015523 I 0.811
myrf.L Xenopus laevis XB-GENE-1020972 I 0.811
myrf Gasterosteus aculeatus ENSGACG00000005416 I 0.804
MYRF Tetraodon nigroviridis ENSTNIG00000016074 I 0.797
ENSMMUG00000006501 Macaca mulatta ENSMMUG00000006501 I 0.722
ENSOARG00000020232 Ovis aries ENSOARG00000020232 I 0.706
Ogr07579 Ophisaurus gracilis Ogr07579 N 0.706