|
NR3C1
(Homo sapiens)
Nuclear receptor
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
PF00105 (zf-C4) |
IPR001628 |
ENSG00000113580 |
T303216_2.00 |
Ensembl (2018-Dec-8) |
Link out |
NCBI Gene Info:This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
NR3C1 M03366_2.00 |
Homo sapiens |
NRGWACAYNRTGTWCYH |
DRGWACAYNRTGTWCYN |
SELEX
Jolma et al.(2013)
NR3C1_1 |
(Direct) |
(Direct) |
NR3C1 M05587_2.00 |
Homo sapiens |
RGDACAYWDTGTHCY |
RGDACAHWRTGTHCY |
SELEX
Yin et al.(2017)
NR3C1_eDBD_HT-SELEX |
(Direct) |
(Direct) |
NR3C1 M05588_2.00 |
Homo sapiens |
RGDACANDRYGTHCY |
RGDACRYHNTGTHCY |
SELEX
Yin et al.(2017)
NR3C1_eDBD_Methyl-HT-SELEX |
(Direct) |
(Direct) |
NR3C1 M07986_2.00 |
Homo sapiens |
DGNACABYBTGTNC |
GNACAVRVTGTNCH |
ChIP-seq
Gerstein et al.(2012)
A549_GR_HudsonAlpha |
(Direct) |
(Direct) |
NR3C1 M07987_2.00 |
Homo sapiens |
NNNNRGNACAYBBTGTHCYNN |
NNRGDACAVVRTGTNCYNNNN |
ChIP-seq
Gerstein et al.(2012)
ECC-1_GR_HudsonAlpha |
(Direct) |
(Direct) |
NR3C1 M09270_2.00 |
Homo sapiens |
DGNACABKNTGTNCY |
RGNACANMVTGTNCH |
Misc
Kulakovskiy et al.(2013)
GCR_HUMAN.H11MO.0.A |
(Direct) |
(Direct) |
NR3C1 M09607_2.00 |
Homo sapiens |
NRGNACABNVTGTNCY |
RGNACABNVTGTNCYN |
Misc
Heinz et al.(2010)
A549-GR_GSE32465 |
(Direct) |
(Direct) |
NR3C1 M11119_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$GR_01 |
(Direct) |
(Direct) |
NR3C1 M11120_2.00 |
Homo sapiens |
KKYACMRDVTGTYCTK |
MAGRACABHYKGTRMM |
Transfac
Matys et al.(2006)
V$GRE_C |
(Direct) |
(Direct) |
NR3C1 M11121_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$GR_Q4 |
(Direct) |
(Direct) |
NR3C1 M11122_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$GR_Q6_01 |
(Direct) |
(Direct) |
NR3C1 M11123_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$GR_Q6_02 |
(Direct) |
(Direct) |
NR3C1 M11124_2.00 |
Homo sapiens |
NNWGVACANWDNNDNBHNN |
NNDVNHNNHWNTGTBCWNN |
Transfac
Matys et al.(2006)
V$GR_Q6 |
(Direct) |
(Direct) |
NR3C1 M11125_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$NR3C1_04 |
(Direct) |
(Direct) |
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Nr3c1
M05886_2.00 |
Mus musculus |
DGDACDBYNTGTNCY |
RGNACANRVHGTHCH |
SMiLE-seq
Isakova et al.(2017)
GR
|
0.994
|
1.000
|
Nr3c1
M09318_2.00 |
Mus musculus |
RGNACABYNTGTNCY |
RGNACANRVTGTNCY |
Misc
Kulakovskiy et al.(2013)
GCR_MOUSE.H11MO.0.A
|
0.994
|
1.000
|
Nr3c1
M09614_2.00 |
Mus musculus |
NRGDACABNNTGTNC |
GNACANNVTGTHCYN |
Misc
Heinz et al.(2010)
RAW264.7-GRE_Unpublished
|
0.994
|
1.000
|
NR3C2
M02395_2.00 |
Homo sapiens |
NNRGDACAN |
NTGTHCYNN |
PBM
Weirauch et al.(2014)
pTH5924
|
0.991
|
0.929
|
NR3C2
M03382_2.00 |
Homo sapiens |
NRGDACAHDRTGTHCYN |
NRGDACAYHDTGTHCYN |
SELEX
Jolma et al.(2013)
NR3C2_1
|
0.991
|
0.929
|
NR3C2
M05637_2.00 |
Homo sapiens |
NGNACRNNNYGTNCN |
NGNACRNNNYGTNCN |
SELEX
Yin et al.(2017)
NR3C2_eDBD_HT-SELEX
|
0.991
|
0.929
|
NR3C2
M05638_2.00 |
Homo sapiens |
NGNACRNNVYGTNCN |
NGNACRBNNYGTNCN |
SELEX
Yin et al.(2017)
NR3C2_eDBD_Methyl-HT-SELEX
|
0.991
|
0.929
|
PGR
M03923_2.00 |
Homo sapiens |
DGNACANNNYGTNCY |
RGNACRNNNTGTNCH |
SELEX
Nitta et al.(2015)
PGR_1
|
0.989
|
0.886
|
PGR
M09266_2.00 |
Homo sapiens |
RGNACWBYBTGTNCYN |
NRGNACAVRVWGTNCY |
Misc
Kulakovskiy et al.(2013)
PRGR_HUMAN.H11MO.0.A
|
0.989
|
0.886
|
Pgr
M09326_2.00 |
Mus musculus |
RGNACWBYNTGTNCY |
RGNACANRVWGTNCY |
Misc
Kulakovskiy et al.(2013)
PRGR_MOUSE.H11MO.0.A
|
0.989
|
0.886
|
PGR
M09603_2.00 |
Homo sapiens |
RNACWNNNWGTNCHN |
NDGNACWNNNWGTNY |
Misc
Heinz et al.(2010)
T47D-PR_GSE31130
|
0.989
|
0.886
|
PGR
M11095_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$PR_01
|
0.989
|
0.886
|
PGR
M11096_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$PR_02
|
0.989
|
0.886
|
PGR
M11097_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$PR_Q6
|
0.984
|
0.843
|
Ar
M00821_2.00 |
Mus musculus |
NRRGAACAYN |
NRTGTTCYYN |
PBM
Weirauch et al.(2013)
pTH1739
|
0.978
|
0.786
|
AR
M03389_2.00 |
Homo sapiens |
DRGWACRHVDYGTWCCY |
RGGWACRHBDYGTWCYH |
SELEX
Jolma et al.(2013)
AR_1
|
0.974
|
0.771
|
AR
M03390_2.00 |
Homo sapiens |
DRGWACAYNRTGTWCYY |
RRGWACAYNRTGTWCYH |
SELEX
Jolma et al.(2013)
AR_2
|
0.974
|
0.771
|
Ar
M03436_2.00 |
Mus musculus |
NRGHACAYNVYGTWCYN |
NRGWACRBNRTGTDCYN |
SELEX
Jolma et al.(2013)
Ar_1
|
0.974
|
0.771
|
AR
M09288_2.00 |
Homo sapiens |
DRYAAAYADNNNRGNACA |
TGTNCYNNNHTRTTTRYH |
Misc
Kulakovskiy et al.(2013)
ANDR_HUMAN.H11MO.0.A
|
0.974
|
0.771
|
Ar
M09331_2.00 |
Mus musculus |
NRGNACABRVTGTNCY |
RGNACABYVTGTNCYN |
Misc
Kulakovskiy et al.(2013)
ANDR_MOUSE.H11MO.0.A
|
0.974
|
0.771
|
AR
M09610_2.00 |
Homo sapiens |
NRGNACABNVTGTNCY |
RGNACABNVTGTNCYN |
Misc
Heinz et al.(2010)
LNCAP-AR_GSE27824
|
0.974
|
0.771
|
AR
M09609_2.00 |
Homo sapiens |
SHDRGVACAS |
STGTBCYHDS |
Misc
Heinz et al.(2010)
LNCaP-AR_GSE27824
|
0.978
|
0.786
|
AR
M11157_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_01
|
0.978
|
0.786
|
AR
M11158_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_02
|
0.974
|
0.771
|
AR
M11159_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_03
|
0.974
|
0.771
|
AR
M11160_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_04
|
0.974
|
0.771
|
AR
M11161_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_11
|
0.974
|
0.771
|
AR
M11162_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_13
|
0.974
|
0.771
|
AR
M11163_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_14_H
|
0.974
|
0.771
|
AR
M11164_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_Q2
|
0.978
|
0.786
|
AR
M11165_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_Q6_01
|
0.978
|
0.786
|
AR
M11166_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AR_Q6
|
0.974
|
0.771
|
For this family, TFs with SR scores > 0.745 will likely have a similar motif |