CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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nhr-18
(
Caenorhabditis elegans
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00105 (zf-C4)
IPR001628
WBGene00003617
T306142_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in anal depressor muscle; intestinal muscle; and vulval muscle. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
CBG01240
M02390_2.00
Caenorhabditis briggsae
BTGTGWCB
VGWCACAV
PBM
Weirauch et al.(2014)
pTH6003
0.767
0.657
For this family, TFs with SR scores >
0.745
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
F44C8.3
Nuclear receptor
9
78
GSCEVCGDKTSGRHFGVMSCRACAAFFRRAATWNLEKRICPNGTCHTSVNGKFNCKQCRLKKCLDVGMDT
Links
Other
Nuclear receptor
family TFs
Other
Caenorhabditis elegans
TFs
6 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
nhr-126
Caenorhabditis elegans
WBGene00003716
N
0.888
nhr-103
Caenorhabditis elegans
WBGene00003693
N
0.885
nhr-134
Caenorhabditis elegans
WBGene00003724
I
0.883
nhr-128
Caenorhabditis elegans
WBGene00003718
N
0.824
CBG01240
Caenorhabditis briggsae
CBG01240
D
0.767
CRE09182
Caenorhabditis remanei
CRE09182
I
0.766