TBX19 (Homo sapiens)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSG00000143178 T339894_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX19
M03562_2.00		 Homo sapiens
NDTVRCACVTANGTGYKANN
NNTMRCACNTABGTGYBAHN		 SELEX
Jolma et al.(2013)
TBX19_1		 (Direct) (Direct)
TBX19
M05803_2.00		 Homo sapiens
NAGGTGYBAHWDTMRCACNTN
NANGTGYKAHWDTVRCACCTN		 SELEX
Yin et al.(2017)
TBX19_eDBD_HT-SELEX		 (Direct) (Direct)
TBX19
M05804_2.00		 Homo sapiens
NANGTGYKAHWDTVRCACSTN
NASGTGYBAHWDTMRCACNTN		 SELEX
Yin et al.(2017)
TBX19_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
T
M05809_2.00 		Homo sapiens
NANGTGYGAHWWNTVRCACCTN
NAGGTGYBANWWDTCRCACNTN		 SELEX
Yin et al.(2017)
T_eDBD_HT-SELEX_1 		0.876 0.835
T
M05810_2.00 		Homo sapiens
DTCRCAYVTABGTGYGAH
DTCRCACVTABRTGYGAH		 SELEX
Yin et al.(2017)
T_eDBD_HT-SELEX_2 		0.876 0.835
T
M09427_2.00 		Homo sapiens
BYNVCANNNVDGTGWKARDN
NHYTMWCACHBNNNTGBNRV		 Misc
Kulakovskiy et al.(2013)
BRAC_HUMAN.H11MO.0.A 		0.876 0.835
T
M09431_2.00 		Mus musculus
VVNRAWTTSACASNYHDVTGBNMAN
NTKNVCABHDRNSTGTSAAWTYNBB		 Misc
Kulakovskiy et al.(2013)
BRAC_MOUSE.H11MO.0.B 		0.876 0.835
T
M09651_2.00 		Mus musculus
NYTVDCASNNNNSTGHBARNN
NNYTVDCASNNNNSTGHBARN		 Misc
Heinz et al.(2010)
Mesoendoderm-Brachyury_GSE54963 		0.876 0.835
T
M11384_2.00 		Homo sapiens
MKHBTSACACSTAGGTGTGAAATK
MATTTCACACCTASGTGTSAVDMK		 Transfac
Matys et al.(2006)
V$BRACH_01 		0.876 0.835
T
M05811_2.00 		Homo sapiens
NABGTGYGAHWWNTVRCACSTN
NASGTGYBANWWDTCRCACVTN		 SELEX
Yin et al.(2017)
T_eDBD_Methyl-HT-SELEX_1 		0.876 0.835
T
M05812_2.00 		Homo sapiens
DTMRCAYVTABGTGYKAH
DTMRCACVTABRTGYKAH		 SELEX
Yin et al.(2017)
T_eDBD_Methyl-HT-SELEX_2 		0.876 0.835
byn
M03984_2.00 		Drosophila melanogaster
ABGTGYGADDD
HHHTCRCACVT		 SELEX
Nitta et al.(2015)
byn_1 		0.816 0.761
byn
M03985_2.00 		Drosophila melanogaster
DNGTGYBAHWWDTVRCACNH
DNGTGYBAHWWDTVRCACNH		 SELEX
Nitta et al.(2015)
byn_2 		0.816 0.761
byn
M03986_2.00 		Drosophila melanogaster
RDGTGYGADNDNDNNNNNNDRDGTGYGADD
HHTCRCACHYHNNNNNNHNHNHTCRCACHY		 SELEX
Nitta et al.(2015)
byn_3 		0.816 0.761
byn
M03987_2.00 		Drosophila melanogaster
NNTMRCAYNWWNRTGYKAHN
NDTMRCAYNWWNRTGYKANN		 SELEX
Nitta et al.(2015)
byn_4 		0.816 0.761
byn
M06453_2.00 		Drosophila melanogaster
ADGTGCDA
THGCACHT		 B1H
Zhu et al.(2011)
byn_FlyReg_FBgn0011723 		0.816 0.761
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356795 T-box 43 218
ENSP00000390731 T-box 10 51
ENSP00000397540 T-box 1 151

Links

Other T-box family TFs
Other Homo sapiens TFs

179 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSSTOG00000019913 Ictidomys tridecemlineatus ENSSTOG00000019913 I 0.920
ENSNLEG00000014917 Nomascus leucogenys ENSNLEG00000014917 I 0.920
TBX19 Equus caballus ENSECAG00000010186 I 0.920
SFT2D2 Macaca mulatta ENSMMUG00000005283 I 0.920
TBX19 Pan troglodytes ENSPTRG00000001647 I 0.920
TBX19 Gorilla gorilla ENSGGOG00000001338 I 0.920
ENSP00000356795 Macaca fascicularis ENSP00000356795 I 0.920
ENSCSAG00000011055 Chlorocebus sabaeus ENSCSAG00000011055 I 0.920
TBX19 Oryctolagus cuniculus ENSOCUG00000014555 I 0.912
ENSMPUG00000000522 Mustela putorius furo ENSMPUG00000000522 I 0.912
TBX19 Canis familiaris ENSCAFG00000015268 I 0.912
TBX19 Cavia porcellus ENSCPOG00000012456 I 0.912
TBX19 Myotis lucifugus ENSMLUG00000011933 I 0.912
TBX19 Vicugna pacos ENSVPAG00000000446 I 0.912
Myotis_brandtii_TBX19_10024384 Myotis brandtii Myotis_brandtii_TBX19_10024384 I 0.912
TBX19 Otolemur garnettii ENSOGAG00000004458 I 0.912
TBX19 Callithrix jacchus ENSCJAG00000016812 I 0.912
TBX19 Felis catus ENSFCAG00000015047 I 0.912
Tbx19 Mus musculus ENSMUSG00000026572 I 0.912
TBX19 Sus scrofa ENSSSCG00000006299 I 0.912
ENSAMEG00000004326 Ailuropoda melanoleuca ENSAMEG00000004326 I 0.909
TBX19 Ochotona princeps ENSOPRG00000016564 I 0.908
TBX19 Microcebus murinus ENSMICG00000007817 I 0.905
TBX19 Loxodonta africana ENSLAFG00000011227 I 0.905
ENSOARG00000012617 Ovis aries ENSOARG00000012617 I 0.903
TBX19 Bos taurus ENSBTAG00000002952 I 0.903
ENSP00000356795-D1 Bos grunniens ENSP00000356795-D1 I 0.903
ENSSHAG00000018940 Sarcophilus harrisii ENSSHAG00000018940 I 0.902
TBX19 Choloepus hoffmanni ENSCHOG00000010387 I 0.893
TBX19 Gallus gallus ENSGALG00000015244 I 0.891
Tbx19 Dipodomys ordii ENSDORG00000014860 I 0.889
Aan_R012309 Calypte anna Aan_R012309 I 0.889
Cmyd_10020966 Chelonia mydas Cmyd_10020966 I 0.884
t2 Xenopus tropicalis XB-GENE-5981736 I 0.882
ENSFALG00000005706 Ficedula albicollis ENSFALG00000005706 I 0.882
Pvit_02210 Pogona vitticeps Pvit_02210 I 0.882
TBX19 Taeniopygia guttata ENSTGUG00000013434 I 0.882
Alligator_sinensis_CCG010779.1 Alligator sinensis Alligator_sinensis_CCG010779.1 I 0.882
Brh_R012030 Buceros rhinoceros Brh_R012030 I 0.882
ENSAPLG00000010506 Anas platyrhynchos ENSAPLG00000010506 I 0.882
TBX19 Anolis carolinensis ENSACAG00000010693 I 0.882
Afo_R013116 Aptenodytes forsteri Afo_R013116 I 0.882
Gfo_R000170 Geospiza fortis Gfo_R000170 I 0.882
T Taeniopygia guttata ENSTGUG00000009448 I 0.881
T Canis familiaris ENSCAFG00000000807 I 0.881
T Ornithorhynchus anatinus ENSOANG00000012289 I 0.881
Pvit_04554 Pogona vitticeps Pvit_04554 I 0.881
T Gallus gallus ENSGALG00000011489 I 0.881
Ogr19099 Ophisaurus gracilis Ogr19099 I 0.881
T Anolis carolinensis ENSACAG00000003467 I 0.881
TBX19 Monodelphis domestica ENSMODG00000002921 I 0.880
ENSOARG00000004863 Ovis aries ENSOARG00000004863 I 0.876
ENSSTOG00000028238 Ictidomys tridecemlineatus ENSSTOG00000028238 I 0.876
ENSNLEG00000011552 Nomascus leucogenys ENSNLEG00000011552 I 0.876
T Tursiops truncatus ENSTTRG00000016665 I 0.876
Cmyd_10017804 Chelonia mydas Cmyd_10017804 I 0.876
ENSMMUP00000022430 Macaca fascicularis ENSMMUP00000022430 I 0.876
ENSSHAG00000018904 Sarcophilus harrisii ENSSHAG00000018904 I 0.876
T Pan troglodytes ENSPTRG00000018789 I 0.876
ENSPANG00000005068 Papio anubis ENSPANG00000005068 I 0.876
ENSPPYG00000017163 Pongo abelii ENSPPYG00000017163 I 0.876
ENSPSIG00000005649 Pelodiscus sinensis ENSPSIG00000005649 I 0.876
T Otolemur garnettii ENSOGAG00000007863 I 0.876
T Rattus norvegicus ENSRNOG00000012229 I 0.876
T Homo sapiens ENSG00000164458 D 0.876
T Loxodonta africana ENSLAFG00000012505 I 0.876
ENSCSAG00000012200 Chlorocebus sabaeus ENSCSAG00000012200 I 0.876
T Gorilla gorilla ENSGGOG00000007693 I 0.876
T Mus musculus ENSMUSG00000062327 D 0.876
T Cavia porcellus ENSCPOG00000001358 I 0.876
T Equus caballus ENSECAG00000007994 I 0.876
T Macaca mulatta ENSMMUG00000017047 I 0.876
T Monodelphis domestica ENSMODG00000006318 I 0.876
T Bos taurus ENSBTAG00000018681 I 0.876
T Callithrix jacchus ENSCJAG00000012508 I 0.876
ENSDNOG00000016178 Dasypus novemcinctus ENSDNOG00000016178 I 0.876
T Ochotona princeps ENSOPRG00000003376 I 0.875
TBX19 Dasypus novemcinctus ENSDNOG00000015810 I 0.875
ENSPSIG00000015509 Pelodiscus sinensis ENSPSIG00000015509 I 0.874
t2.S Xenopus laevis XB-GENE-5981788 I 0.856
Alligator_sinensis_CCG019781.1 Alligator sinensis Alligator_sinensis_CCG019781.1 I 0.854
TriadG25521 Trichoplax adhaerens TriadG25521 I 0.852
ENSLOCG00000010586 Lepisosteus oculatus ENSLOCG00000010586 I 0.851
tbxt.L Xenopus laevis XB-GENE-6255736 I 0.851
tbxt Xenopus tropicalis XB-GENE-478789 I 0.851
tbxt.S Xenopus laevis XB-GENE-865212 I 0.849
1XBR_A Xenopus laevis 1XBR_A I 0.849
ENSLOCG00000016526 Lepisosteus oculatus ENSLOCG00000016526 I 0.849
1XBR_B Xenopus laevis 1XBR_B I 0.849
ENSLACG00000015449 Latimeria chalumnae ENSLACG00000015449 I 0.849
ENSONIG00000009906 Oreochromis niloticus ENSONIG00000009906 I 0.849
ENSXMAG00000011123 Xiphophorus maculatus ENSXMAG00000011123 I 0.849
tb Danio rerio ENSDARG00000039806 I 0.847
tb Oryzias latipes ENSORLG00000011262 I 0.847
ENSPFOG00000016071 Poecilia formosa ENSPFOG00000016071 I 0.841
T Oryctolagus cuniculus ENSOCUG00000000660 I 0.835
estExt_gwp.C_650221 Branchiostoma floridae estExt_gwp.C_650221 I 0.831
estExt_GenewiseH_1.C_9340011 Branchiostoma floridae estExt_GenewiseH_1.C_9340011 I 0.831
estExt_gwp.C_9340008 Branchiostoma floridae estExt_gwp.C_9340008 I 0.830
estExt_fgenesh2_pg.C_650149 Branchiostoma floridae estExt_fgenesh2_pg.C_650149 I 0.830
tb Tetraodon nigroviridis ENSTNIG00000016613 I 0.829
tb Takifugu rubripes ENSTRUG00000011958 I 0.828
tbx19 Danio rerio ENSDARG00000079187 I 0.824
ENSGMOG00000017391 Gadus morhua ENSGMOG00000017391 I 0.823
CLEC002870 Cimex lectularius CLEC002870 I 0.823
RPRC001186 Rhodnius prolixus RPRC001186 I 0.823
PHUM392580 Pediculus humanus PHUM392580 I 0.821
MCINX002868 Melitaea cinxia MCINX002868 I 0.818
BGIBMGA000322 Bombyx mori BGIBMGA000322 I 0.818
tbx19 Tetraodon nigroviridis ENSTNIG00000006586 I 0.817
ENSONIG00000008985 Oreochromis niloticus ENSONIG00000008985 I 0.817
NV14821 Nasonia vitripennis NV14821 I 0.816
byn Drosophila melanogaster FBgn0011723 D 0.816
GF25302 Drosophila ananassae FBgn0102294 I 0.816
Hsal_03707--XP_396427.2_APIME Harpegnathos saltator Hsal_03707--XP_396427.2_APIME I 0.816
LCUP008716 Lucilia cuprina LCUP008716 I 0.816
Cflo_04209--XP_396427.2_APIME Camponotus floridanus Cflo_04209--XP_396427.2_APIME I 0.816
MDOA012486 Musca domestica MDOA012486 I 0.816
GE21864 Drosophila yakuba FBgn0239106 I 0.816
GA20217 Drosophila pseudoobscura FBgn0080212 I 0.816
GM25308 Drosophila sechellia FBgn0180168 I 0.816
GL25108 Drosophila persimilis FBgn0162695 I 0.816
GH14805 Drosophila grimshawi FBgn0122281 I 0.816
GI11508 Drosophila mojavensis FBgn0134268 I 0.816
GD14339 Drosophila simulans FBgn0186024 I 0.816
GK25266 Drosophila willistoni FBgn0227225 I 0.816
GG15542 Drosophila erecta FBgn0107790 I 0.816
GJ13700 Drosophila virilis FBgn0200921 I 0.816
ENSAMXG00000003991 Astyanax mexicanus ENSAMXG00000003991 I 0.815
TC014076 Tribolium castaneum TC014076 I 0.813
tbx19 Takifugu rubripes ENSTRUG00000005718 I 0.812
ENSLACG00000011042 Latimeria chalumnae ENSLACG00000011042 I 0.812
XP_002164912.1 Hydra magnipapillata XP_002164912.1 I 0.810
ML174736a Mnemiopsis leidyi ML174736a I 0.809
LotgiG154800 Lottia gigantea LotgiG154800 I 0.806
ta Takifugu rubripes ENSTRUG00000012130 I 0.803
CPIJ011372 Culex quinquefasciatus CPIJ011372 I 0.802
CpipJ_CPIJ011372 Culex pipiens CpipJ_CPIJ011372 I 0.802
CGI_10018059 Crassostrea gigas CGI_10018059 I 0.801
AALB003755 Anopheles albimanus AALB003755 I 0.799
ENSONIG00000007611 Oreochromis niloticus ENSONIG00000007611 I 0.799
AARA000721 Anopheles arabiensis AARA000721 I 0.799
AAEL011926 Aedes aegypti AAEL011926 I 0.799
ENSPFOG00000002451 Poecilia formosa ENSPFOG00000002451 I 0.799
me-t Oryzias latipes ENSORLG00000014067 I 0.799
ENSGMOG00000018941 Gadus morhua ENSGMOG00000018941 I 0.799
ACUA027826 Anopheles culicifacies ACUA027826 I 0.799
AQUA010101 Anopheles quadriannulatus AQUA010101 I 0.799
ASIS006984 Anopheles sinensis ASIS006984 I 0.799
ASTEI05115 Anopheles stephensi ASTEI05115 I 0.799
AMIN008605 Anopheles minimus AMIN008605 I 0.799
AFUN010277 Anopheles funestus AFUN010277 I 0.799
ADIR001942 Anopheles dirus ADIR001942 I 0.799
AEPI011219 Anopheles epiroticus AEPI011219 I 0.799
ACOM032190 Anopheles coluzzii ACOM032190 I 0.799
ta Gasterosteus aculeatus ENSGACG00000007637 I 0.799
ADAC000433 Anopheles darlingi ADAC000433 I 0.799
ENSXMAG00000012033 Xiphophorus maculatus ENSXMAG00000012033 I 0.799
Alligator_sinensis_CCG010961.2 Alligator sinensis Alligator_sinensis_CCG010961.2 I 0.799
ta Danio rerio ENSDARG00000101576 I 0.799
AGAP011927 Anopheles gambiae AGAP011927 I 0.799
tb Gasterosteus aculeatus ENSGACG00000005258 I 0.798
AMEC020399 Anopheles melas AMEC020399 I 0.798
Gfo_R011100 Geospiza fortis Gfo_R011100 N 0.798
ENSAMXG00000013638 Astyanax mexicanus ENSAMXG00000013638 I 0.796
ENSLOCG00000003838 Lepisosteus oculatus ENSLOCG00000003838 I 0.796
ta Tetraodon nigroviridis ENSTNIG00000005634 I 0.796
ENSPFOG00000006034 Poecilia formosa ENSPFOG00000006034 I 0.792
ENSXMAG00000006226 Xiphophorus maculatus ENSXMAG00000006226 I 0.791
Sakowv30011577m.g Saccoglossus kowalevskii Sakowv30011577m.g I 0.785
ENSCSAVG00000002247 Ciona savignyi ENSCSAVG00000002247 I 0.783
brachyury Ciona intestinalis ENSCING00000000810 I 0.778
ENSAMEG00000009278 Ailuropoda melanoleuca ENSAMEG00000009278 I 0.774
GB51013 Apis mellifera GB51013 I 0.765
SNAPOd2T00000418001 Oikopleura dioica SNAPOd2T00000418001 I 0.762
DAPPUDRAFT_44582 Daphnia pulex DAPPUDRAFT_44582 I 0.757
XP_002154016.1 Hydra magnipapillata XP_002154016.1 I 0.747
SMAR005933 Strigamia maritima SMAR005933 I 0.747
T Meleagris gallopavo ENSMGAG00000012328 N 0.744