ENSBTAP00000015683-D1 (Bos grunniens)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00907 (T-box) IPR001699 ENSBTAP00000015683-D1 T341050_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbx1
M00832_2.00 		Mus musculus
NRGTGTGAANN
NNTTCACACYN		 PBM
Weirauch et al.(2013)
pTH3822 		0.867 0.890
TBX1
M03570_2.00 		Homo sapiens
ARGTGTKAAAWHARGTGTGA
TCACACYTDWTTTMACACYT		 SELEX
Jolma et al.(2013)
TBX1_1 		0.867 0.890
TBX1
M03571_2.00 		Homo sapiens
AGGTGTGAWWTTCACACCT
AGGTGTGAAWWTCACACCT		 SELEX
Jolma et al.(2013)
TBX1_2 		0.867 0.890
TBX1
M03572_2.00 		Homo sapiens
AGGTGTGA
TCACACCT		 SELEX
Jolma et al.(2013)
TBX1_3 		0.867 0.890
TBX1
M03573_2.00 		Homo sapiens
YYTCACACMTYWRAGGTGTGAAA
TTTCACACCTYWRAKGTGTGARR		 SELEX
Jolma et al.(2013)
TBX1_4 		0.867 0.890
TBX1
M03574_2.00 		Homo sapiens
YTCACACCTDKAGGTGTGAA
TTCACACCTMHAGGTGTGAR		 SELEX
Jolma et al.(2013)
TBX1_5 		0.867 0.890
TBX1
M05821_2.00 		Homo sapiens
BDRGGTGTGARV
BYTCACACCYHV		 SELEX
Yin et al.(2017)
TBX1_eDBD_HT-SELEX 		0.867 0.890
Tbx1
M11386_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX1_07 		0.867 0.890
TBX1
M05822_2.00 		Homo sapiens
DNWGGTGTGARN
NYTCACACCWNH		 SELEX
Yin et al.(2017)
TBX1_eDBD_Methyl-HT-SELEX 		0.867 0.890
org-1
M03988_2.00 		Drosophila melanogaster
DRGTGTBAD
HTVACACYH		 SELEX
Nitta et al.(2015)
org-1_1 		0.737 0.703
org-1
M03989_2.00 		Drosophila melanogaster
TRACACYTARGTGTGA
TCACACYTARGTGTYA		 SELEX
Nitta et al.(2015)
org-1_2 		0.737 0.703
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000015683-D1 T-box 67 252

Links

Other T-box family TFs
Other Bos grunniens TFs

125 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
TBX10 Pteropus vampyrus ENSPVAG00000008592 I 0.920
Myotis_brandtii_Tbx10_10030825 Myotis brandtii Myotis_brandtii_Tbx10_10030825 I 0.920
TBX10 Felis catus ENSFCAG00000001760 I 0.919
TBX10 Canis familiaris ENSCAFG00000011264 I 0.919
ENSMPUG00000004076 Mustela putorius furo ENSMPUG00000004076 I 0.919
ENSCSAG00000008726 Chlorocebus sabaeus ENSCSAG00000008726 I 0.911
TBX10 Homo sapiens ENSG00000167800 I 0.911
ENSP00000335191 Macaca fascicularis ENSP00000335191 I 0.911
ENSMMUG00000018529 Macaca mulatta ENSMMUG00000018529 I 0.911
TBX10 Gorilla gorilla ENSGGOG00000011961 I 0.911
ENSPANG00000006501 Papio anubis ENSPANG00000006501 I 0.911
ENSAMEG00000001098 Ailuropoda melanoleuca ENSAMEG00000001098 I 0.910
Tbx10 Mus musculus ENSMUSG00000037477 I 0.909
ENSSTOG00000011629 Ictidomys tridecemlineatus ENSSTOG00000011629 I 0.909
TBX10 Otolemur garnettii ENSOGAG00000000784 I 0.906
TBX10 Procavia capensis ENSPCAG00000009585 I 0.904
ENSMEUG00000007568 Macropus eugenii ENSMEUG00000007568 I 0.901
Tbx10 Rattus norvegicus ENSRNOG00000017944 I 0.901
Tbx10 Dipodomys ordii ENSDORG00000010070 I 0.901
TBX10 Pan troglodytes ENSPTRG00000003972 I 0.898
TBX10 Monodelphis domestica ENSMODG00000021334 I 0.885
TBX10 Bos taurus ENSBTAG00000011816 I 0.884
TBX1 Otolemur garnettii ENSOGAG00000003596 I 0.870
tbx1.L Xenopus laevis XB-GENE-478088 I 0.869
ENSPFOG00000009621 Poecilia formosa ENSPFOG00000009621 I 0.869
TBX1 Monodelphis domestica ENSMODG00000021176 I 0.869
tbx1.S Xenopus laevis XB-GENE-6254396 I 0.869
tbx1 Xenopus tropicalis XB-GENE-478084 I 0.869
Pvit_15846 Pogona vitticeps Pvit_15846 I 0.869
tbx1 Oryzias latipes ENSORLG00000015256 I 0.869
ENSONIG00000015827 Oreochromis niloticus ENSONIG00000015827 I 0.869
ENSPFOG00000009540 Poecilia formosa ENSPFOG00000009540 I 0.869
tbx1 Takifugu rubripes ENSTRUG00000014017 I 0.869
tbx1 Tetraodon nigroviridis ENSTNIG00000016767 I 0.869
TBX1 Taeniopygia guttata ENSTGUG00000008395 I 0.869
tbx1 Gasterosteus aculeatus ENSGACG00000013057 I 0.869
ENSFALG00000008041 Ficedula albicollis ENSFALG00000008041 I 0.869
tbx1 Danio rerio ENSDARG00000031891 I 0.869
ENSGMOG00000018613 Gadus morhua ENSGMOG00000018613 I 0.869
ENSAMXG00000020444 Astyanax mexicanus ENSAMXG00000020444 I 0.869
ENSMEUG00000011624 Macropus eugenii ENSMEUG00000011624 I 0.869
ENSLACG00000016333 Latimeria chalumnae ENSLACG00000016333 I 0.869
TBX1 Loxodonta africana ENSLAFG00000021555 I 0.867
TBX1 Dasypus novemcinctus ENSDNOG00000035422 I 0.867
ENSCSAG00000011818 Chlorocebus sabaeus ENSCSAG00000011818 I 0.867
ENSP00000331791-D2 Bos grunniens ENSP00000331791-D2 I 0.867
ENSSTOG00000004505 Ictidomys tridecemlineatus ENSSTOG00000004505 I 0.867
Tbx1 Rattus norvegicus ENSRNOG00000001892 I 0.867
ENSPANG00000015763 Papio anubis ENSPANG00000015763 I 0.867
TBX1 Callithrix jacchus ENSCJAG00000014591 I 0.867
ENSFCAG00000005446 Felis catus ENSFCAG00000005446 I 0.867
ENSGGOG00000009181 Gorilla gorilla ENSGGOG00000009181 I 0.867
TBX1 Homo sapiens ENSG00000184058 D 0.867
Tbx1 Mus musculus ENSMUSG00000009097 D 0.867
SMAR009230 Strigamia maritima SMAR009230 I 0.862
Pvit_16222 Pogona vitticeps Pvit_16222 I 0.862
ENSMGAG00000004357 Meleagris gallopavo ENSMGAG00000004357 I 0.859
ENSACAG00000008549 Anolis carolinensis ENSACAG00000008549 I 0.859
ENSLACG00000004994 Latimeria chalumnae ENSLACG00000004994 I 0.857
ENSOARG00000013751 Ovis aries ENSOARG00000013751 I 0.856
Ogr08509 Ophisaurus gracilis Ogr08509 I 0.854
fgenesh2_kg.scaffold_118000001 Branchiostoma floridae fgenesh2_kg.scaffold_118000001 I 0.846
Aan_R010744 Calypte anna Aan_R010744 I 0.846
ENSMPUG00000003900 Mustela putorius furo ENSMPUG00000003900 I 0.845
ENSTGUG00000007382 Taeniopygia guttata ENSTGUG00000007382 I 0.845
ENSGALG00000003599 Gallus gallus ENSGALG00000003599 I 0.843
DAPPUDRAFT_3881 Daphnia pulex DAPPUDRAFT_3881 I 0.843
PHUM607490 Pediculus humanus PHUM607490 I 0.835
ACYPI001903 Acyrthosiphon pisum ACYPI001903 I 0.833
Alligator_sinensis_CCG022145.1 Alligator sinensis Alligator_sinensis_CCG022145.1 I 0.832
L798_01101 Zootermopsis nevadensis L798_01101 I 0.832
Myotis_brandtii_Tbx1_10021844 Myotis brandtii Myotis_brandtii_Tbx1_10021844 I 0.830
LotgiG104372 Lottia gigantea LotgiG104372 I 0.824
YQE_10853 Dendroctonus ponderosae YQE_10853 I 0.819
CapteG226618 Capitella teleta CapteG226618 I 0.817
tetur04g00890 Tetranychus urticae tetur04g00890 I 0.816
GB55445 Apis mellifera GB55445 I 0.814
CGI_10008753 Crassostrea gigas CGI_10008753 I 0.808
LDEC008541 Leptinotarsa decemlineata LDEC008541 I 0.805
Cflo_09868--XP_624689.2_APIME Camponotus floridanus Cflo_09868--XP_624689.2_APIME I 0.805
TC015327 Tribolium castaneum TC015327 I 0.805
Hsal_04471--XP_624689.2_APIME Harpegnathos saltator Hsal_04471--XP_624689.2_APIME I 0.805
TBX1 Procavia capensis ENSPCAG00000010176 I 0.804
NV11904 Nasonia vitripennis NV11904 I 0.802
Sakowv30001714m.g Saccoglossus kowalevskii Sakowv30001714m.g I 0.802
ENSCSAVG00000000786 Ciona savignyi ENSCSAVG00000000786 I 0.801
CLEC006885 Cimex lectularius CLEC006885 I 0.799
HMEL015536 Heliconius melpomene HMEL015536 I 0.796
KGM_08622 Danaus plexippus KGM_08622 I 0.796
Gfo_R011877 Geospiza fortis Gfo_R011877 I 0.791
BGIBMGA013132 Bombyx mori BGIBMGA013132 I 0.785
TBX10 Tursiops truncatus ENSTTRG00000003781 N 0.782
NEMVEDRAFT_v1g214571 Nematostella vectensis NEMVEDRAFT_v1g214571 I 0.763
ENSPFOG00000007309 Poecilia formosa ENSPFOG00000007309 I 0.762
MDOA001403 Musca domestica MDOA001403 I 0.759
LLOJ005386 Lutzomyia longipalpis LLOJ005386 I 0.757
AEPI001144 Anopheles epiroticus AEPI001144 I 0.751
AFAF008331 Anopheles farauti AFAF008331 I 0.751
ADIR010556 Anopheles dirus ADIR010556 I 0.751
AATE015045 Anopheles atroparvus AATE015045 I 0.751
AFUN001113 Anopheles funestus AFUN001113 I 0.751
ACUA026816 Anopheles culicifacies ACUA026816 I 0.751
AMEC007874 Anopheles melas AMEC007874 I 0.751
AQUA006531 Anopheles quadriannulatus AQUA006531 I 0.751
ASIS010497 Anopheles sinensis ASIS010497 I 0.751
AMIN000536 Anopheles minimus AMIN000536 I 0.751
AMEM018425 Anopheles merus AMEM018425 I 0.751
AARA001806 Anopheles arabiensis AARA001806 I 0.751
AMAM012836 Anopheles maculatus AMAM012836 I 0.751
AALB002686 Anopheles albimanus AALB002686 I 0.751
CPIJ007784 Culex quinquefasciatus CPIJ007784 I 0.751
CpipJ_CPIJ007784 Culex pipiens CpipJ_CPIJ007784 I 0.751
AAEL018165 Aedes aegypti AAEL018165 I 0.751
ENSTNIG00000014352 Tetraodon nigroviridis ENSTNIG00000014352 I 0.740
GH12234 Drosophila grimshawi FBgn0119713 I 0.737
GL20248 Drosophila persimilis FBgn0157843 I 0.737
GI15769 Drosophila mojavensis FBgn0138518 I 0.737
GE17455 Drosophila yakuba FBgn0234921 I 0.737
GG19051 Drosophila erecta FBgn0111257 I 0.737
org-1 Drosophila melanogaster FBgn0021767 D 0.737
GK19893 Drosophila willistoni FBgn0221891 I 0.737
GJ18625 Drosophila virilis FBgn0205781 I 0.737
GM21356 Drosophila sechellia FBgn0176237 I 0.737
GA10837 Drosophila pseudoobscura FBgn0070893 I 0.737
GF22584 Drosophila ananassae FBgn0099578 I 0.737