rbr-2 (Caenorhabditis elegans)
ARID/BRIGHT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01388 (ARID) IPR001606 WBGene00004319 T015803_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables histone H3-tri/di/monomethyl-lysine-4 demethylase activity. Involved in determination of adult lifespan; histone H3-K4 demethylation; and regulation of vulval development. Located in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in ankylosing spondylitis; autosomal recessive non-syndromic intellectual disability; breast cancer; high grade glioma; and syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to several human genes including KDM5A (lysine demethylase 5A); KDM5B (lysine demethylase 5B); and KDM5C (lysine demethylase 5C). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ZK593.4a ARID/BRIGHT 123 214
ZK593.4b ARID/BRIGHT 90 181

Links

Other ARID/BRIGHT family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

6 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action