CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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neurog3
(
Danio rerio
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSDARG00000016951
T033647_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in endocrine pancreas; gut; and hypothalamus. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
NEUROG2
M02799_2.00
Homo sapiens
RMCATATGBY
RVCATATGKY
SELEX
Jolma et al.(2013)
NEUROG2_1
0.842
0.846
NEUROG2
M02800_2.00
Homo sapiens
RMCATATGBY
RVCATATGKY
SELEX
Jolma et al.(2013)
NEUROG2_2
0.842
0.846
NEUROG2
M04179_2.00
Homo sapiens
RVCATATGBY
RVCATATGBY
SELEX
Yin et al.(2017)
NEUROG2_eDBD_HT-SELEX
0.842
0.846
NEUROG2
M04181_2.00
Homo sapiens
RVCATRTGBY
RVCAYATGBY
SELEX
Yin et al.(2017)
NEUROG2_FL_HT-SELEX
0.842
0.846
Neurog2
M08758_2.00
Mus musculus
VBRRCAGATGGB
VCCATCTGYYVB
Misc
Kulakovskiy et al.(2013)
NGN2_MOUSE.H11MO.0.C
0.842
0.846
NEUROG2
M09879_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NGN2_Q3
0.842
0.846
NEUROG2
M04180_2.00
Homo sapiens
RVCATATGBY
RVCATATGBY
SELEX
Yin et al.(2017)
NEUROG2_eDBD_Methyl-HT-SELEX
0.842
0.846
NEUROG2
M04182_2.00
Homo sapiens
RMCRTRTGYY
RRCAYAYGKY
SELEX
Yin et al.(2017)
NEUROG2_FL_Methyl-HT-SELEX
0.842
0.846
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000106489
bHLH
79
131
RRVKANDRERHRMHNLNSALDNLRSVLPTFPDDAKLTKIETLRFAHNYIWALS
Links
Other
bHLH
family TFs
Other
Danio rerio
TFs
97 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy