TWIST1 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000122691 T034273_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Homo sapiens

Mathelier et al.(2014)
(Direct) (Direct)
Homo sapiens

Kulakovskiy et al.(2013)
(Direct) (Direct)
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
(Direct) (Direct)
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Mus musculus

Kulakovskiy et al.(2013)
0.914 1.000
Mus musculus

Weirauch et al.(2014)
0.914 0.962
Drosophila melanogaster

Nitta et al.(2015)
0.859 0.865
Drosophila melanogaster

Nitta et al.(2015)
0.859 0.865
Drosophila melanogaster

Zhu et al.(2011)
0.859 0.865
Drosophila melanogaster

Zhu et al.(2011)
0.859 0.865
Drosophila melanogaster

DNaseI footprinting
Mathelier et al.(2014)
0.859 0.865
Drosophila melanogaster

Kulakovskiy et al.(2009)
0.859 0.865
Drosophila melanogaster Transfac license required
Transfac license required
Matys et al.(2006)
0.859 0.865
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000242261 bHLH 109 160
ENSP00000346582 bHLH 42 93
ENSP00000416986 bHLH 1 28


Other bHLH family TFs
Other Homo sapiens TFs

236 Related TFs

Name Species Gene ID Motif Evidence SR
AAEL002902 Aedes aegypti AAEL002902 I 0.903
AALB010655 Anopheles albimanus AALB010655 I 0.847
Aan_R001044 Calypte anna Aan_R001044 I 0.914
Aan_R002857 Calypte anna Aan_R002857 I 0.914
AARA000771 Anopheles arabiensis AARA000771 I 0.847
AATE005140 Anopheles atroparvus AATE005140 I 0.903
ACEP23430 Atta cephalotes ACEP23430 I 0.890
ACHR006076 Anopheles christyi ACHR006076 I 0.847
ACOM023427 Anopheles coluzzii ACOM023427 I 0.903
ACUA022223 Anopheles culicifacies ACUA022223 I 0.847
ACYPI001448 Acyrthosiphon pisum ACYPI001448 I 0.903
ADIR004364 Anopheles dirus ADIR004364 I 0.847
AEPI000695 Anopheles epiroticus AEPI000695 I 0.847
AFAF020800 Anopheles farauti AFAF020800 I 0.903
Afo_R010658 Aptenodytes forsteri Afo_R010658 I 0.914
Afo_R013292 Aptenodytes forsteri Afo_R013292 I 0.894
AFUN009694 Anopheles funestus AFUN009694 I 0.847
AGAP011985 Anopheles gambiae AGAP011985 I 0.903
Alligator_sinensis_CCG002585.1 Alligator sinensis Alligator_sinensis_CCG002585.1 I 0.914
Alligator_sinensis_CCG005115.1 Alligator sinensis Alligator_sinensis_CCG005115.1 I 0.894
Alligator_sinensis_CCG008488.1 Alligator sinensis Alligator_sinensis_CCG008488.1 I 0.914
AMEC000330 Anopheles melas AMEC000330 I 0.903
AMEM016167 Anopheles merus AMEM016167 I 0.847
AMIN004405 Anopheles minimus AMIN004405 I 0.847
AQUA008654 Anopheles quadriannulatus AQUA008654 I 0.847
ASTEI05879 Anopheles stephensi ASTEI05879 I 0.903
A_07561 Schistosoma haematobium A_07561 I 0.859
BGIBMGA008990 Bombyx mori BGIBMGA008990 I 0.873
BGLB003400 Biomphalaria glabrata BGLB003400 I 0.903
BGLB010605 Biomphalaria glabrata BGLB010605 I 0.855
Brh_R012765 Buceros rhinoceros Brh_R012765 I 0.914
CapteG111042 Capitella teleta CapteG111042 I 0.900
CapteG154829 Capitella teleta CapteG154829 I 0.903
Cflo_04586--NP_001011637.1_APIME Camponotus floridanus Cflo_04586--NP_001011637.1_APIME I 0.890
CGI_10006631 Crassostrea gigas CGI_10006631 I 0.903
CGI_10013641 Crassostrea gigas CGI_10013641 I 0.879
CLEC011700 Cimex lectularius CLEC011700 I 0.914
Cmyd_10002489 Chelonia mydas Cmyd_10002489 I 0.894
Cmyd_10006750 Chelonia mydas Cmyd_10006750 I 0.914
CPIJ012827 Culex quinquefasciatus CPIJ012827 I 0.847
CPIJ012828 Culex quinquefasciatus CPIJ012828 I 0.847
CpipJ_CPIJ012827 Culex pipiens CpipJ_CPIJ012827 I 0.847
CpipJ_CPIJ012828 Culex pipiens CpipJ_CPIJ012828 I 0.847
csin110283 Clonorchis sinensis csin110283 I 0.859
D917_00468 Trichinella nativa D917_00468 I 0.890
D918_07072 Trichuris suis D918_07072 I 0.890
DAPPUDRAFT_320202 Daphnia pulex DAPPUDRAFT_320202 I 0.914
DILT_0001206901 Diphyllobothrium latum DILT_0001206901 I 0.859
ECANG7_02703 Echinococcus canadensis ECANG7_02703 I 0.859
ECPE_0000551801 Echinostoma caproni ECPE_0000551801 I 0.859
EFV58362 Trichinella spiralis EFV58362 I 0.890
EmuJ_000663800 Echinococcus multilocularis EmuJ_000663800 I 0.859
ENSACAG00000009715 Anolis carolinensis ENSACAG00000009715 I 0.903
ENSACAG00000015086 Anolis carolinensis ENSACAG00000015086 I 0.883
ENSAMEG00000008556 Ailuropoda melanoleuca ENSAMEG00000008556 I 0.914
ENSAMEG00000020165 Ailuropoda melanoleuca ENSAMEG00000020165 I 0.914
ENSAMXG00000024993 Astyanax mexicanus ENSAMXG00000024993 I 0.879
ENSAMXG00000025039 Astyanax mexicanus ENSAMXG00000025039 I 0.883
ENSAMXG00000025095 Astyanax mexicanus ENSAMXG00000025095 I 0.903
ENSAMXG00000025610 Astyanax mexicanus ENSAMXG00000025610 I 0.890
ENSAMXG00000025657 Astyanax mexicanus ENSAMXG00000025657 I 0.903
ENSAPLG00000000878 Anas platyrhynchos ENSAPLG00000000878 I 0.914
ENSAPLG00000007177 Anas platyrhynchos ENSAPLG00000007177 I 0.914
ENSCSAG00000018801 Chlorocebus sabaeus ENSCSAG00000018801 I 0.914
ENSCSAG00000019610 Chlorocebus sabaeus ENSCSAG00000019610 I 0.914
ENSDORG00000012866 Dipodomys ordii ENSDORG00000012866 I 0.914
ENSETEG00000013115 Echinops telfairi ENSETEG00000013115 I 0.914
ENSFALG00000009781 Ficedula albicollis ENSFALG00000009781 I 0.914
ENSFALG00000014990 Ficedula albicollis ENSFALG00000014990 I 0.914
ENSFALG00000015081 Ficedula albicollis ENSFALG00000015081 I 0.870
ENSGALG00000004274 Gallus gallus ENSGALG00000004274 I 0.914
ENSGALG00000006321 Gallus gallus ENSGALG00000006321 I 0.894
ENSGALG00000026059 Gallus gallus ENSGALG00000026059 I 0.914
ENSGMOG00000002790 Gadus morhua ENSGMOG00000002790 I 0.903
ENSGMOG00000003155 Gadus morhua ENSGMOG00000003155 I 0.883
ENSLACG00000012096 Latimeria chalumnae ENSLACG00000012096 I 0.914
ENSLACG00000013366 Latimeria chalumnae ENSLACG00000013366 I 0.914
ENSLACG00000019113 Latimeria chalumnae ENSLACG00000019113 I 0.894
ENSLOCG00000017835 Lepisosteus oculatus ENSLOCG00000017835 I 0.914
ENSLOCG00000018198 Lepisosteus oculatus ENSLOCG00000018198 I 0.883
ENSLOCG00000018350 Lepisosteus oculatus ENSLOCG00000018350 I 0.914
ENSMEUG00000013853 Macropus eugenii ENSMEUG00000013853 I 0.914
ENSMGAG00000002218 Meleagris gallopavo ENSMGAG00000002218 I 0.914
ENSMMUP00000014629 Macaca fascicularis ENSMMUP00000014629 I 0.468
ENSMODG00000001412 Monodelphis domestica ENSMODG00000001412 I 0.914
ENSMPUG00000019429 Mustela putorius furo ENSMPUG00000019429 I 0.914
ENSNLEG00000011342 Nomascus leucogenys ENSNLEG00000011342 I 0.914
ENSNLEG00000019264 Nomascus leucogenys ENSNLEG00000019264 I 0.914
ENSOANG00000012950 Ornithorhynchus anatinus ENSOANG00000012950 I 0.914
ENSOARG00000000265 Ovis aries ENSOARG00000000265 I 0.914
ENSOARG00000009754 Ovis aries ENSOARG00000009754 I 0.914
ENSONIG00000020502 Oreochromis niloticus ENSONIG00000020502 I 0.890
ENSONIG00000020610 Oreochromis niloticus ENSONIG00000020610 I 0.890
ENSONIG00000021177 Oreochromis niloticus ENSONIG00000021177 I 0.883
ENSONIG00000021342 Oreochromis niloticus ENSONIG00000021342 I 0.879
ENSONIG00000021420 Oreochromis niloticus ENSONIG00000021420 I 0.879
ENSP00000405176-D1 Bos grunniens ENSP00000405176-D1 I 0.914
ENSPANG00000001578 Papio anubis ENSPANG00000001578 I 0.914
ENSPFOG00000019887 Poecilia formosa ENSPFOG00000019887 I 0.890
ENSPFOG00000020053 Poecilia formosa ENSPFOG00000020053 I 0.890
ENSPFOG00000020314 Poecilia formosa ENSPFOG00000020314 I 0.879
ENSPFOG00000020501 Poecilia formosa ENSPFOG00000020501 I 0.883
ENSPMAG00000003993 Petromyzon marinus ENSPMAG00000003993 I 0.903
ENSPMAG00000010126 Petromyzon marinus ENSPMAG00000010126 I 0.903
ENSPPYG00000017754 Pongo abelii ENSPPYG00000017754 I 0.914
ENSPSIG00000001961 Pelodiscus sinensis ENSPSIG00000001961 I 0.894
ENSPSIG00000012843 Pelodiscus sinensis ENSPSIG00000012843 I 0.914
ENSPTRG00000018960 Pan troglodytes ENSPTRG00000018960 I 0.914
ENSSHAG00000003328 Sarcophilus harrisii ENSSHAG00000003328 I 0.914
ENSSTOG00000004633 Ictidomys tridecemlineatus ENSSTOG00000004633 I 0.914
ENSTGUG00000003194 Taeniopygia guttata ENSTGUG00000003194 I 0.914
ENSTGUG00000003756 Taeniopygia guttata ENSTGUG00000003756 I 0.870
ENSXMAG00000019787 Xiphophorus maculatus ENSXMAG00000019787 I 0.890
ENSXMAG00000019956 Xiphophorus maculatus ENSXMAG00000019956 I 0.883
ENSXMAG00000019999 Xiphophorus maculatus ENSXMAG00000019999 I 0.903
ENSXMAG00000020062 Xiphophorus maculatus ENSXMAG00000020062 I 0.879
ENSXMAG00000020142 Xiphophorus maculatus ENSXMAG00000020142 I 0.890
estExt_gwp.C_4170045 Branchiostoma floridae estExt_gwp.C_4170045 I 0.914
fgenesh2_pm.scaffold_217000008 Branchiostoma floridae fgenesh2_pm.scaffold_217000008 I 0.914
GB40416 Apis mellifera GB40416 I 0.879
GF13559 Drosophila ananassae FBgn0090588 I 0.859
Gfo_R002785 Geospiza fortis Gfo_R002785 I 0.777
Gfo_R012065 Geospiza fortis Gfo_R012065 I 0.914
Gfo_R014393 Geospiza fortis Gfo_R014393 I 0.870
GH20971 Drosophila grimshawi FBgn0128433 I 0.859
GI21307 Drosophila mojavensis FBgn0144037 I 0.859
GK19547 Drosophila willistoni FBgn0221545 I 0.859
GL11229 Drosophila persimilis FBgn0148838 I 0.859
GM15978 Drosophila sechellia FBgn0170894 I 0.859
HDID_0001003601 Hymenolepis diminuta HDID_0001003601 I 0.859
HelroG155122 Helobdella robusta HelroG155122 I 0.880
HMEL011603 Heliconius melpomene HMEL011603 I 0.873
HmN_000912800 Hymenolepis microstoma HmN_000912800 I 0.859
HNAJ_0000179601 Hymenolepis nana HNAJ_0000179601 I 0.859
Hsal_01530--NP_001011637.1_APIME Harpegnathos saltator Hsal_01530--NP_001011637.1_APIME I 0.879
ISCW009433 Ixodes scapularis ISCW009433 I 0.879
KGM_08280 Danaus plexippus KGM_08280 I 0.873
L798_05856 Zootermopsis nevadensis L798_05856 I 0.914
LCUP006189 Lucilia cuprina LCUP006189 I 0.859
LDEC006528 Leptinotarsa decemlineata LDEC006528 I 0.914
LLOJ002131 Lutzomyia longipalpis LLOJ002131 I 0.855
LotgiG179182 Lottia gigantea LotgiG179182 I 0.858
MCOS_0000111401 Mesocestoides corti MCOS_0000111401 I 0.859
MDOA005417 Musca domestica MDOA005417 I 0.859
Myotis_brandtii_Twist1_10031742 Myotis brandtii Myotis_brandtii_Twist1_10031742 I 0.914
NEMVEDRAFT_v1g234699 Nematostella vectensis NEMVEDRAFT_v1g234699 I 0.844
nRc.2.0.1.g46228 Romanomermis culicivorax nRc.2.0.1.g46228 I 0.870
NV10141 Nasonia vitripennis NV10141 I 0.879
Ocbimv22015922m.g Octopus bimaculoides Ocbimv22015922m.g I 0.914
Ogr01719 Ophisaurus gracilis Ogr01719 I 0.894
Ogr06591 Ophisaurus gracilis Ogr06591 I 0.914
Ogr11552 Ophisaurus gracilis Ogr11552 I 0.914
Ogr11553 Ophisaurus gracilis Ogr11553 I 0.914
PHUM396880 Pediculus humanus PHUM396880 I 0.903
PPAI002101 Phlebotomus papatasi PPAI002101 I 0.844
Pvit_02271 Pogona vitticeps Pvit_02271 I 0.914
Pvit_05844 Pogona vitticeps Pvit_05844 I 0.894
RPRC000323 Rhodnius prolixus RPRC000323 I 0.901
Sakowv30001350m.g Saccoglossus kowalevskii Sakowv30001350m.g I 0.903
SINV20920 Solenopsis invicta SINV20920 I 0.914
Sjc_0042560 Schistosoma japonicum Sjc_0042560 I 0.859
Smp_203270 Schistosoma mansoni Smp_203270 I 0.859
SMU15037660 Schmidtea mediterranea SMU15037660 I 0.870
SPU_030059 Strongylocentrotus purpuratus SPU_030059 I 0.859
SSLN_0000059301 Schistocephalus solidus SSLN_0000059301 I 0.859
TASK_0000180901 Taenia asiatica TASK_0000180901 I 0.859
TC014598 Tribolium castaneum TC014598 I 0.914
tetur03g03150 Tetranychus urticae tetur03g03150 I 0.849
TMUE_s0004013100 Trichuris muris TMUE_s0004013100 I 0.890
TsM_000716700 Taenia solium TsM_000716700 I 0.859
TTRE_0000397101 Trichuris trichiura TTRE_0000397101 I 0.890
twi Drosophila erecta FBgn0064598 I 0.859
twi Drosophila simulans FBgn0016355 I 0.859
twi Drosophila pseudoobscura FBgn0243556 I 0.859
twi Drosophila virilis FBgn0020065 I 0.859
twi Drosophila melanogaster FBgn0003900 D 0.859
twi Drosophila yakuba FBgn0084444 I 0.859
TWIST1 Myotis lucifugus ENSMLUG00000007047 I 0.914
TWIST1 Macaca mulatta ENSMMUG00000011173 I 0.914
twist1 Takifugu rubripes ENSTRUG00000015797 I 0.890
TWIST1 Bos taurus ENSBTAG00000046922 I 0.914
twist1 Xenopus tropicalis XB-GENE-479802 I 0.879
TWIST1 Meleagris gallopavo ENSMGAG00000009311 I 0.894
TWIST1 Dasypus novemcinctus ENSDNOG00000037354 I 0.914
TWIST1 Gasterosteus aculeatus ENSGACG00000006420 I 0.890
TWIST1 Tetraodon nigroviridis ENSTNIG00000001678 I 0.890
twist1 Anolis carolinensis ENSACAG00000011825 I 0.914
TWIST1 Erinaceus europaeus ENSEEUG00000015333 I 0.914
TWIST1 Monodelphis domestica ENSMODG00000023924 I 0.914
Twist1 Rattus norvegicus ENSRNOG00000011101 I 0.914
TWIST1 Oryzias latipes ENSORLG00000004012 I 0.914
Twist1 Mus musculus ENSMUSG00000035799 D 0.914
twist1 Oryzias latipes ENSORLG00000007251 I 0.890
TWIST1 Taeniopygia guttata ENSTGUG00000002643 I 0.914
TWIST1 Pteropus vampyrus ENSPVAG00000001710 I 0.914
TWIST1 Ornithorhynchus anatinus ENSOANG00000009614 I 0.914
TWIST1 Sus scrofa ENSSSCG00000015370 I 0.914
twist1.L Xenopus laevis XB-GENE-6255840 I 0.879
twist1.S Xenopus laevis XB-GENE-865309 I 0.879
twist1a Danio rerio ENSDARG00000030402 I 0.890
twist1b Gasterosteus aculeatus ENSGACG00000008070 I 0.914
twist1b Danio rerio ENSDARG00000076010 I 0.890
twist1b Tetraodon nigroviridis ENSTNIG00000018440 I 0.890
TWIST2 Dasypus novemcinctus ENSDNOG00000002434 I 0.914
twist2 Danio rerio ENSDARG00000078266 I 0.879
TWIST2 Pan troglodytes ENSPTRG00000033910 I 0.914
TWIST2 Bos taurus ENSBTAG00000021444 I 0.914
twist2 Tetraodon nigroviridis ENSTNIG00000001562 I 0.879
TWIST2 Callithrix jacchus ENSCJAG00000023006 I 0.914
TWIST2 Cavia porcellus ENSCPOG00000025980 I 0.914
TWIST2 Sus scrofa ENSSSCG00000016343 I 0.914
twist2 Gasterosteus aculeatus ENSGACG00000002227 I 0.879
Twist2 Dipodomys ordii ENSDORG00000005906 I 0.874
TWIST2 Myotis lucifugus ENSMLUG00000023316 I 0.914
Twist2 Rattus norvegicus ENSRNOG00000020355 I 0.914
TWIST2 Otolemur garnettii ENSOGAG00000029007 I 0.914
TWIST2 Oryctolagus cuniculus ENSOCUG00000004073 I 0.914
twist2 Xenopus tropicalis XB-GENE-5878700 I 0.883
TWIST2 Loxodonta africana ENSLAFG00000032174 I 0.914
TWIST2 Canis familiaris ENSCAFG00000012469 I 0.914
TWIST2 Ochotona princeps ENSOPRG00000017069 I 0.914
TWIST2 Macaca mulatta ENSMMUG00000021909 I 0.914
twist2 Takifugu rubripes ENSTRUG00000006090 I 0.879
TWIST2 Homo sapiens ENSG00000233608 I 0.914
TWIST2 Echinops telfairi ENSETEG00000009809 I 0.914
Twist2 Mus musculus ENSMUSG00000007805 D 0.914
twist2 Oryzias latipes ENSORLG00000018096 I 0.879
twist3 Oryzias latipes ENSORLG00000016373 I 0.883
twist3 Tetraodon nigroviridis ENSTNIG00000000441 I 0.903
twist3 Takifugu rubripes ENSTRUG00000012607 I 0.903
twist3 Takifugu rubripes ENSTRUG00000011374 I 0.883
twist3 Gasterosteus aculeatus ENSGACG00000007963 I 0.883
twist3 Danio rerio ENSDARG00000019646 I 0.883
twist3b Gasterosteus aculeatus ENSGACG00000004773 I 0.883
YQE_04855 Dendroctonus ponderosae YQE_04855 I 0.914