Myc (Mus musculus)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000022346 T035680_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Mus musculus

Kulakovskiy et al.(2013)
(Direct) (Direct)
Mus musculus

Heinz et al.(2010)
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000022971 bHLH 370 422
ENSMUSP00000022971 bHLH 429 452
ENSMUSP00000123821 bHLH 355 407
ENSMUSP00000123821 bHLH 414 437
ENSMUSP00000123852 bHLH 355 407
ENSMUSP00000123852 bHLH 414 437
ENSMUSP00000124758 bHLH 355 407
ENSMUSP00000124758 bHLH 414 437
ENSMUSP00000130285 bHLH 369 421
ENSMUSP00000130285 bHLH 428 451
ENSMUSP00000140183 bHLH 370 422
ENSMUSP00000140183 bHLH 429 452
ENSMUSP00000141139 bHLH 369 421
ENSMUSP00000141139 bHLH 428 451


Other bHLH family TFs
Other Mus musculus TFs

35 Related TFs

Name Species Gene ID Motif Evidence SR
MYC Loxodonta africana ENSLAFG00000001410 I 0.914
ENSPPYG00000018878 Pongo abelii ENSPPYG00000018878 I 0.914
ENSDORG00000010277 Dipodomys ordii ENSDORG00000010277 I 0.914
ENSCSAG00000010109 Chlorocebus sabaeus ENSCSAG00000010109 I 0.898
ENSNLEG00000005570 Nomascus leucogenys ENSNLEG00000005570 I 0.898
ENSMPUG00000001327 Mustela putorius furo ENSMPUG00000001327 I 0.898
MYC Macaca mulatta ENSMMUG00000014601 I 0.898
MYC Oryctolagus cuniculus ENSOCUG00000014289 I 0.898
ENSPANG00000010418 Papio anubis ENSPANG00000010418 I 0.898
MYC Tupaia belangeri ENSTBEG00000005715 I 0.898
MYC Sorex araneus ENSSARG00000010372 I 0.898
Myc Rattus norvegicus ENSRNOG00000004500 I 0.898
ENSMMUP00000019164 Macaca fascicularis ENSMMUP00000019164 I 0.898
ENSAMEG00000014717 Ailuropoda melanoleuca ENSAMEG00000014717 I 0.898
MYC Callithrix jacchus ENSCJAG00000012620 I 0.898
MYC Canis familiaris ENSCAFG00000001086 I 0.898
MYC Dasypus novemcinctus ENSDNOG00000048399 I 0.898
MYC Felis catus ENSFCAG00000025438 I 0.898
MYC Taeniopygia guttata ENSTGUG00000012513 I 0.891
ENSAPLG00000013997 Anas platyrhynchos ENSAPLG00000013997 I 0.891
ENSMGAG00000015875 Meleagris gallopavo ENSMGAG00000015875 I 0.891
Cmyd_10008050 Chelonia mydas Cmyd_10008050 I 0.891
ENSGALG00000016308 Gallus gallus ENSGALG00000016308 I 0.891
Gfo_R001095 Geospiza fortis Gfo_R001095 I 0.890
ENSFALG00000002546 Ficedula albicollis ENSFALG00000002546 I 0.890
MYC Vicugna pacos ENSVPAG00000005895 I 0.888
MYC Sus scrofa ENSSSCG00000005965 I 0.887
MYC Erinaceus europaeus ENSEEUG00000001458 I 0.879
ENSPSIG00000008301 Pelodiscus sinensis ENSPSIG00000008301 I 0.879
ENSSTOG00000004944 Ictidomys tridecemlineatus ENSSTOG00000004944 I 0.875
ENSOANG00000008107 Ornithorhynchus anatinus ENSOANG00000008107 I 0.852
Myotis_brandtii_MYC_10012350 Myotis brandtii Myotis_brandtii_MYC_10012350 I 0.846
MYC Microcebus murinus ENSMICG00000014990 I 0.846
MYC Myotis lucifugus ENSMLUG00000026933 I 0.846