CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Hes1
(
Rattus norvegicus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSRNOG00000001720
T037163_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; generation of neurons; and regulation of gene expression. Located in chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hes1
M01726_2.00
Mus musculus
NVCACGYKNN
NNMRCGTGBN
PBM
Weirauch et al.(2014)
pTH5059
0.914
1.000
HES1
M04090_2.00
Homo sapiens
VVCACGYGHM
KDCRCGTGBB
SELEX
Yin et al.(2017)
HES1_eDBD_HT-SELEX
0.914
1.000
HES1
M09822_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HES1_Q2
0.914
1.000
HES1
M09823_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HES1_Q3
0.914
1.000
HES1
M09824_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HES1_Q4
0.914
1.000
HES1
M09825_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HES1_Q6
0.914
1.000
HES1
M04091_2.00
Homo sapiens
VNYACNYNHN
NDNRNGTRNB
SELEX
Yin et al.(2017)
HES1_eDBD_Methyl-HT-SELEX
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000002346
bHLH
35
92
RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQ
Links
Other
bHLH
family TFs
Other
Rattus norvegicus
TFs
112 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy