CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ac
(
Drosophila melanogaster
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
FBgn0000022
T038386_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; chaeta morphogenesis; and positive regulation of antibacterial peptide biosynthetic process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including ectoderm; extended germ band embryo; neuroblasts; presumptive embryonic/larval system; and thoracic segment. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ac
M03592_2.00
Drosophila melanogaster
AAAARCAGCTGYTTTT
AAAARCAGCTGYTTTT
SELEX
Nitta et al.(2015)
ac_1
(Direct)
(Direct)
ac
M05902_2.00
Drosophila melanogaster
RCACCTGC
GCAGGTGY
B1H
Zhu et al.(2011)
ac_da_SANGER_5_FBgn0000022
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0070071
bHLH
27
91
IRRNARERNRVKQVNNGFSQLRQHIPAAVIADLSNGRRGIGPGANKKLSKVSTLKMAVEYIRRLQ
Links
Other
bHLH
family TFs
Other
Drosophila melanogaster
TFs
3 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy