CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

Fer2 *(Drosophila melanogaster)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	FBgn0038402	T038447_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables chromatin binding activity. Involved in negative regulation of oxidative stress-induced neuron death; positive regulation of autophagy; and response to oxidative stress. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Used to study Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Fer2 M05994_2.00	Drosophila melanogaster	MCABSTGACR	YGTCASVTGK	B1H Zhu et al.(2011) Fer2_da_SANGER_5_FBgn0038402	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
For this family, TFs with SR scores > 0.838* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
FBpp0290923	bHLH	148	201	QRQAANVRERKRIQSSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLR
FBpp0310461	bHLH	148	206	QRQAANVRERKRIQRSAPTGSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLR
FBpp0310462	bHLH	148	164	QRQAANVRERKRIQRSA
FBpp0310462	bHLH	170	210	KCSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLR
FBpp0310463	bHLH	148	201	QRQAANVRERKRIQSSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLR

Links
Other bHLH family TFs
Other *Drosophila melanogaster* TFs