NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and uterus. Orthologous to several human genes including HES1 (hes family bHLH transcription factor 1) and HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022] |