ENSBTAP00000011351-D1 (Bos grunniens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSBTAP00000011351-D1 T047136_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000011351-D1 bHLH 38 86

Links

Other bHLH family TFs
Other Bos grunniens TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AHRR Bos taurus ENSBTAG00000026527 N 0.914
AHRR Equus caballus ENSECAG00000017812 N 0.884
ENSMPUG00000010246 Mustela putorius furo ENSMPUG00000010246 N 0.882
ENSAMEG00000008443 Ailuropoda melanoleuca ENSAMEG00000008443 N 0.882
AHRR Ochotona princeps ENSOPRG00000013408 N 0.882
AHRR Felis catus ENSFCAG00000015430 N 0.882
ENSOARG00000015756 Ovis aries ENSOARG00000015756 N 0.882
AHRR Myotis lucifugus ENSMLUG00000012589 N 0.856
fgenesh2_pg.scaffold_330000001 Branchiostoma floridae fgenesh2_pg.scaffold_330000001 N 0.856
ENSOCUG00000021638 Oryctolagus cuniculus ENSOCUG00000021638 N 0.855
AHRR Otolemur garnettii ENSOGAG00000010416 N 0.852
ENSPSIG00000007107 Pelodiscus sinensis ENSPSIG00000007107 N 0.852
ENSMMUP00000001012 Macaca fascicularis ENSMMUP00000001012 N 0.852
ENSTGUG00000008731 Taeniopygia guttata ENSTGUG00000008731 N 0.852
ENSPANG00000023865 Papio anubis ENSPANG00000023865 N 0.852
PDCD6 Macaca mulatta ENSMMUG00000000752 N 0.852
ENSCSAG00000017432 Chlorocebus sabaeus ENSCSAG00000017432 N 0.852
ENSAPLG00000013653 Anas platyrhynchos ENSAPLG00000013653 N 0.852
AHRR Homo sapiens ENSG00000063438 N 0.852
AHRR Gallus gallus ENSGALG00000013402 N 0.852
AHRR Meleagris gallopavo ENSMGAG00000007591 N 0.852
AHRR Gorilla gorilla ENSGGOG00000013694 N 0.852
ENSNLEG00000010815 Nomascus leucogenys ENSNLEG00000010815 N 0.852