CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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brk
(
Drosophila melanogaster
)
Brinker
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF09607 (BrkDBD)
IPR018586
FBgn0024250
T055663_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell competition in a multicellular organism; negative regulation of BMP signaling pathway; and posterior Malpighian tubule development. Located in nucleus. Is expressed in several structures, including embryonic epidermis; extended germ band embryo; germ layer; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
brk
M03628_2.00
Drosophila melanogaster
WRGCGCCGGCGCYW
WRGCGCCGGCGCYW
SELEX
Nitta et al.(2015)
brk_1
(Direct)
(Direct)
brk
M03629_2.00
Drosophila melanogaster
WRGCGCCAGGCGCYW
WRGCGCCTGGCGCYW
SELEX
Nitta et al.(2015)
brk_2
(Direct)
(Direct)
brk
M03630_2.00
Drosophila melanogaster
WRGCGCCATGGCGCYW
WRGCGCCATGGCGCYW
SELEX
Nitta et al.(2015)
brk_3
(Direct)
(Direct)
brk
M06013_2.00
Drosophila melanogaster
RGCGCCRS
SYGGCGCY
B1H
Zhu et al.(2011)
brk_FlyReg_FBgn0024250
(Direct)
(Direct)
brk
M07539_2.00
Drosophila melanogaster
RGCGCCRS
SYGGCGCY
DNaseI footprinting
Mathelier et al.(2014)
MA0213.1
(Direct)
(Direct)
brk
M09658_2.00
Drosophila melanogaster
BHRRCGCCABBHVV
BBDVVTGGCGYYDV
Misc
Kulakovskiy et al.(2009)
brk
(Direct)
(Direct)
brk
M09903_2.00
Drosophila melanogaster
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$BRK_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0071007
Brinker
43
100
GSRRIFTPHFKLQVLESYRNDNDCKGNQRATARKYNIHRRQIQKWLQCESNLRSSVAN
Links
Other
Brinker
family TFs
Other
Drosophila melanogaster
TFs
16 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy