ATF6B (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000213676 T059768_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ATF6B
M04041_2.00		 Homo sapiens
GRTGACGTGGCR
YGCCACGTCAYC		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.1		 (Direct) (Direct)
ATF6B
M04042_2.00		 Homo sapiens
YGMCACGTGKCR
YGMCACGTGKCR		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.2		 (Direct) (Direct)
ATF6B
M04043_2.00		 Homo sapiens
RTGACGTCAYC
GRTGACGTCAY		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.3		 (Direct) (Direct)
ATF6B
M04044_2.00		 Homo sapiens
MCCACGATGT
ACATCGTGGK		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.4		 (Direct) (Direct)
ATF6B
M04375_2.00		 Homo sapiens
NRTGACGTCAYN
NRTGACGTCAYN		 SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_1		 (Direct) (Direct)
ATF6B
M04376_2.00		 Homo sapiens
NRTGACGTGGCR
YGCCACGTCAYN		 SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_2		 (Direct) (Direct)
ATF6B
M04377_2.00		 Homo sapiens
TGCCACGTGGCR
YGCCACGTGGCA		 SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_3		 (Direct) (Direct)
ATF6B
M04378_2.00		 Homo sapiens
SRTGACGTCAYB
VRTGACGTCAYS		 SELEX
Yin et al.(2017)
ATF6B_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
ATF6B
M04379_2.00		 Homo sapiens
BRTGACGTGGCR
YGCCACGTCAYV		 SELEX
Yin et al.(2017)
ATF6B_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ATF6
M04254_2.00 		Homo sapiens
YKRTGACGTGGCAN
NTGCCACGTCAYMR		 SELEX
Yin et al.(2017)
ATF6_eDBD_HT-SELEX_1 		0.832 0.625
ATF6
M04255_2.00 		Homo sapiens
NRTGACGTCAYN
NRTGACGTCAYN		 SELEX
Yin et al.(2017)
ATF6_eDBD_HT-SELEX_2 		0.832 0.625
ATF6
M04018_2.00 		Homo sapiens
GRTGACGTGGCR
YGCCACGTCAYC		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6.1 		0.832 0.625
ATF6
M04019_2.00 		Homo sapiens
KAGTCACGTGK
MCACGTGACTM		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6.2 		0.832 0.625
ATF6
M04020_2.00 		Homo sapiens
BNRTGACGTCATCA
TGATGACGTCAYNV		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6.3 		0.832 0.625
ATF6
M04021_2.00 		Homo sapiens
ACCACGATGTY
RACATCGTGGT		 SELEX
Rodriguez-Martinez et al.(2017)
ATF6.4 		0.832 0.625
ATF6
M08790_2.00 		Homo sapiens
VBSSTGACGTGG
CCACGTCASSVB		 Misc
Kulakovskiy et al.(2013)
ATF6A_HUMAN.H11MO.0.B 		0.832 0.625
ATF6
M09947_2.00 		Homo sapiens
TGACGTGG
CCACGTCA		 Transfac
Matys et al.(2006)
V$ATF6_01 		0.832 0.625
ATF6
M04256_2.00 		Homo sapiens
YGRTGACGTGGCRN
NYGCCACGTCAYCR		 SELEX
Yin et al.(2017)
ATF6_eDBD_Methyl-HT-SELEX_1 		0.832 0.625
ATF6
M04257_2.00 		Homo sapiens
NRTGACGTCAYN
NRTGACGTCAYN		 SELEX
Yin et al.(2017)
ATF6_eDBD_Methyl-HT-SELEX_2 		0.832 0.625
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000364347 bZIP 320 386
ENSP00000364349 bZIP 323 389

Links

Other bZIP family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

112 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action