| NCBI Gene Info:Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including determination of adult lifespan; nuclear migration along microtubule; and nuclear pore localization. Located in nuclear envelope and nuclear periphery. Is expressed widely. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to several human genes including LMNA (lamin A/C). [provided by Alliance of Genome Resources, Apr 2022] |