REF6 (Arabidopsis thaliana)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 AT3G48430 T080858_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Relative of Early Flowering 6 (REF6) encodes a Jumonji N/C and zinc finger domain-containing protein that acts as a positive regulator of flowering in an FLC-dependent pathway. REF6 mutants have hyperacetylation of histone H4 at the FLC locus. REF6 interacts with BES1 in a Y2H assay and in vitro. REF6 may play a role in brassinoteroid signaling by affecting histone methylation in the promoters of BR-responsive genes. It is most closely related to the JHDM3 subfamily of JmjN/C proteins.

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
REF6
M08081_2.00		 Arabidopsis thaliana
DNCTCTGTTTY
RAAACAGAGNH		 ChIP-seq
Mathelier et al.(2014)
MA1415.1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
AT3G48430.1 C2H2 ZF 1243 1266
AT3G48430.1 C2H2 ZF 1267 1290
AT3G48430.1 C2H2 ZF 1296 1320
AT3G48430.1 C2H2 ZF 1326 1352
AT3G48430.2 C2H2 ZF 884 907
AT3G48430.2 C2H2 ZF 908 931
AT3G48430.2 C2H2 ZF 937 961
AT3G48430.2 C2H2 ZF 967 993

Links

Other C2H2 ZF family TFs
Other Arabidopsis thaliana TFs

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9 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action