zbtb18 (Danio rerio)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSDARG00000028228 T090874_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; optic cup; and somite. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZBTB18
M02916_2.00 		Homo sapiens
VMACATCTGGAWN
NWTCCAGATGTKB		 SELEX
Jolma et al.(2013)
ZNF238_1 		0.821 0.978
ZBTB18
M02917_2.00 		Homo sapiens
NMACATCTGGMHN
NDKCCAGATGTKN		 SELEX
Jolma et al.(2013)
ZNF238_2 		0.821 0.978
ZBTB18
M04585_2.00 		Homo sapiens
NMACATCTGGMHN
NDKCCAGATGTKN		 SELEX
Yin et al.(2017)
ZBTB18_eDBD_HT-SELEX 		0.821 0.978
ZBTB18
M08350_2.00 		Homo sapiens
MRCAKCTGG
CCAGMTGYK		 ChIP-seq
Schmitges et al.(2016)
Q99592_2-4.RCADE 		0.821 0.978
ZBTB18
M08928_2.00 		Homo sapiens
VMRCAKCTGGV
BCCAGMTGYKB		 Misc
Kulakovskiy et al.(2013)
ZBT18_HUMAN.H11MO.0.C 		0.821 0.978
ZBTB18
M10282_2.00 		Homo sapiens
NNMACATCTGGM
KCCAGATGTKNN		 Transfac
Matys et al.(2006)
V$RP58_01 		0.821 0.978
ZBTB18
M10283_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RP58_Q3 		0.821 0.978
ZBTB18
M04586_2.00 		Homo sapiens
NMACATCTGBHNN
NNDVCAGATGTKN		 SELEX
Yin et al.(2017)
ZBTB18_eDBD_Methyl-HT-SELEX 		0.821 0.978
ZBTB18
M08257_2.00 		Homo sapiens
NMGCAGCTGCKB
VMGCAGCTGCKN		 ChIP-seq
Najafabadi et al.(2015b)
ZNF238 		0.821 0.978
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000141791 C2H2 ZF 385 407
ENSDARP00000141791 C2H2 ZF 426 447
ENSDARP00000141791 C2H2 ZF 453 475
ENSDARP00000141791 C2H2 ZF 481 504

Links

Other C2H2 ZF family TFs
Other Danio rerio TFs

65 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMXG00000002993 Astyanax mexicanus ENSAMXG00000002993 I 0.827
ENSLOCG00000017349 Lepisosteus oculatus ENSLOCG00000017349 I 0.822
ENSGMOG00000018718 Gadus morhua ENSGMOG00000018718 I 0.822
ZBTB18 Sorex araneus ENSSARG00000002984 I 0.821
ZBTB18 Taeniopygia guttata ENSTGUG00000008247 I 0.821
ENSSHAG00000008659 Sarcophilus harrisii ENSSHAG00000008659 I 0.821
ENSSTOG00000004290 Ictidomys tridecemlineatus ENSSTOG00000004290 I 0.821
Zfp238 Rattus norvegicus ENSRNOG00000004423 I 0.821
ZBTB18 Pteropus vampyrus ENSPVAG00000011441 I 0.821
ZBTB18 Otolemur garnettii ENSOGAG00000013580 I 0.821
ZBTB18 Anolis carolinensis ENSACAG00000004296 I 0.821
ENSPANG00000021934 Papio anubis ENSPANG00000021934 I 0.821
ENSPPYG00000000059 Pongo abelii ENSPPYG00000000059 I 0.821
ZBTB18 Pan troglodytes ENSPTRG00000002175 I 0.821
ENSTSYG00000004607 Tarsius syrichta ENSTSYG00000004607 I 0.821
ZBTB18 Tursiops truncatus ENSTTRG00000000615 I 0.821
Pvit_01078 Pogona vitticeps Pvit_01078 I 0.821
Myotis_brandtii_ZNF238_10003031 Myotis brandtii Myotis_brandtii_ZNF238_10003031 I 0.821
AAH70718 Xenopus laevis AAH70718 I 0.821
zbtb18 Xenopus tropicalis XB-GENE-1003542 I 0.821
zbtb18.L Xenopus laevis XB-GENE-1003548 I 0.821
Gfo_R011040 Geospiza fortis Gfo_R011040 I 0.821
ENSP00000351539 Macaca fascicularis ENSP00000351539 I 0.821
Afo_R000236 Aptenodytes forsteri Afo_R000236 I 0.821
Aan_R007004 Calypte anna Aan_R007004 I 0.821
Brh_R000160 Buceros rhinoceros Brh_R000160 I 0.821
Cmyd_10016351 Chelonia mydas Cmyd_10016351 I 0.821
ENSBTAP00000000497-D1 Bos grunniens ENSBTAP00000000497-D1 I 0.821
ZBTB18 Ornithorhynchus anatinus ENSOANG00000010257 I 0.821
ZBTB18 Oryctolagus cuniculus ENSOCUG00000007968 I 0.821
ZBTB18 Gallus gallus ENSGALG00000010705 I 0.821
ENSCPOG00000023254 Cavia porcellus ENSCPOG00000023254 I 0.821
ZBTB18 Callithrix jacchus ENSCJAG00000017087 I 0.821
ZBTB18 Gorilla gorilla ENSGGOG00000028442 I 0.821
ENSLACG00000009889 Latimeria chalumnae ENSLACG00000009889 I 0.821
ZBTB18 Dasypus novemcinctus ENSDNOG00000009334 I 0.821
ZBTB18 Homo sapiens ENSG00000179456 D 0.821
ZBTB18 Equus caballus ENSECAG00000018829 I 0.821
ZBTB18 Erinaceus europaeus ENSEEUG00000014181 I 0.821
ENSFALG00000011473 Ficedula albicollis ENSFALG00000011473 I 0.821
ENSFCAG00000026731 Felis catus ENSFCAG00000026731 I 0.821
ENSDORG00000000569 Dipodomys ordii ENSDORG00000000569 I 0.821
ZBTB18 Loxodonta africana ENSLAFG00000002879 I 0.821
ENSAPLG00000002367 Anas platyrhynchos ENSAPLG00000002367 I 0.821
ZBTB18 Monodelphis domestica ENSMODG00000006570 I 0.821
ENSAMEG00000019750 Ailuropoda melanoleuca ENSAMEG00000019750 I 0.821
ENSMPUG00000015734 Mustela putorius furo ENSMPUG00000015734 I 0.821
Zbtb18 Mus musculus ENSMUSG00000063659 I 0.821
ZBTB18 Bos taurus ENSBTAG00000000385 I 0.821
ZBTB18 Macaca mulatta ENSMMUG00000015664 I 0.821
ZBTB18 Meleagris gallopavo ENSMGAG00000011476 I 0.821
ENSMEUG00000009369 Macropus eugenii ENSMEUG00000009369 I 0.821
ZBTB18 Microcebus murinus ENSMICG00000007600 I 0.821
ZBTB18 Myotis lucifugus ENSMLUG00000011285 I 0.821
ENSNLEG00000003981 Nomascus leucogenys ENSNLEG00000003981 I 0.816
ENSOARG00000005939 Ovis aries ENSOARG00000005939 I 0.811
ENSSSCG00000030070 Sus scrofa ENSSSCG00000030070 I 0.786
zbtb18 Tetraodon nigroviridis ENSTNIG00000000430 I 0.785
zbtb18 Oryzias latipes ENSORLG00000004823 I 0.785
ENSONIG00000000862 Oreochromis niloticus ENSONIG00000000862 I 0.785
ENSXMAG00000018241 Xiphophorus maculatus ENSXMAG00000018241 I 0.785
ENSPFOG00000022080 Poecilia formosa ENSPFOG00000022080 I 0.785
zbtb18 Takifugu rubripes ENSTRUG00000000952 I 0.785
zbtb18 Gasterosteus aculeatus ENSGACG00000010518 I 0.785
znf238.2.L Xenopus laevis XB-GENE-1219070 I 0.768