GTF3A (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000122034 T094879_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Homo sapiens

Schmitges et al.(2016)
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000370532 C2H2 ZF 40 64
ENSP00000370532 C2H2 ZF 70 94
ENSP00000370532 C2H2 ZF 100 125
ENSP00000370532 C2H2 ZF 132 156
ENSP00000370532 C2H2 ZF 162 186
ENSP00000370532 C2H2 ZF 189 213
ENSP00000370532 C2H2 ZF 218 239
ENSP00000370532 C2H2 ZF 246 271
ENSP00000370532 C2H2 ZF 277 301
ENSP00000389655 C2H2 ZF 40 64
ENSP00000389655 C2H2 ZF 70 94
ENSP00000389655 C2H2 ZF 100 125
ENSP00000389655 C2H2 ZF 132 156
ENSP00000393050 C2H2 ZF 128 152
ENSP00000393050 C2H2 ZF 158 183
ENSP00000393050 C2H2 ZF 190 214
ENSP00000393050 C2H2 ZF 220 244
ENSP00000393050 C2H2 ZF 247 271
ENSP00000393050 C2H2 ZF 276 297
ENSP00000393050 C2H2 ZF 304 329
ENSP00000393050 C2H2 ZF 335 359
ENSP00000409175 C2H2 ZF 40 64
ENSP00000409175 C2H2 ZF 70 94
ENSP00000409175 C2H2 ZF 100 125


Other C2H2 ZF family TFs
Other Homo sapiens TFs

13 Related TFs

Name Species Gene ID Motif Evidence SR
GTF3A Pan troglodytes ENSPTRG00000005730 I 0.827
ENSNLEG00000000331 Nomascus leucogenys ENSNLEG00000000331 I 0.827
GTF3A Macaca mulatta ENSMMUG00000009029 I 0.825
ENSCSAG00000017983 Chlorocebus sabaeus ENSCSAG00000017983 N 0.825
ENSPANG00000012593 Papio anubis ENSPANG00000012593 I 0.824
ENSPPYG00000005235 Pongo abelii ENSPPYG00000005235 I 0.822
ENSMMUP00000011834 Macaca fascicularis ENSMMUP00000011834 N 0.819
GTF3A Callithrix jacchus ENSCJAG00000019373 N 0.813
GTF3A Otolemur garnettii ENSOGAG00000014589 N 0.776
GTF3A Tupaia belangeri ENSTBEG00000012075 N 0.763
Myotis_brandtii_GTF3A_10026415 Myotis brandtii Myotis_brandtii_GTF3A_10026415 I 0.761
GTF3A Myotis lucifugus ENSMLUG00000002158 I 0.761
GTF3A Canis familiaris ENSCAFG00000006794 I 0.760