NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and sensory perception of sound. Located in nucleus. Is expressed in several structures, including embryonic/larval nervous system; embryonic/larval tracheal system; extended germ band embryo; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome; coloboma; and middle lobe syndrome. Orthologous to human SALL1 (spalt like transcription factor 1); SALL2 (spalt like transcription factor 2); and SALL3 (spalt like transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022] |