CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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opa
(
Drosophila melanogaster
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
FBgn0003002
T114404_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including eye-antennal disc morphogenesis; germ cell migration; and midgut development. Located in nucleus. Is expressed in several structures, including ectoderm anlage; germ layer; mesoderm anlage; parasegment; and visceral muscle primordium. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome; X-linked VACTERL association; craniosynostosis; holoprosencephaly (multiple); and visceral heterotaxy (multiple). Orthologous to several human genes including ZIC1 (Zic family member 1); ZIC2 (Zic family member 2); and ZIC4 (Zic family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
opa
M03668_2.00
Drosophila melanogaster
BVCCCCCCRYNGHB
VDCNRYGGGGGGBV
SELEX
Nitta et al.(2015)
opa_1
(Direct)
(Direct)
opa
M05861_2.00
Drosophila melanogaster
VCCCCCCRYNGNK
MNCNRYGGGGGGB
SMiLE-seq
Isakova et al.(2017)
Opa
(Direct)
(Direct)
opa
M06062_2.00
Drosophila melanogaster
GMCCCCCCRCDG
CHGYGGGGGGKC
B1H
Zhu et al.(2011)
opa_NAR_FBgn0003002
(Direct)
(Direct)
opa
M06063_2.00
Drosophila melanogaster
MKVMMCCCCMCYR
YRGKGGGGKKBMK
B1H
Zhu et al.(2011)
Opa_SANGER_5_FBgn0003002
(Direct)
(Direct)
opa
M06468_2.00
Drosophila melanogaster
GMCCCCCCGCDG
CHGCGGGGGGKC
B1H
Mathelier et al.(2014)
MA0456.1
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ref-2
M00621_2.00
Caenorhabditis elegans
CMYRSNGNBH
DVNCNSYRKG
PBM
Narasimhan et al.(2015)
pTH9089
0.757
0.739
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0078477
C2H2 ZF
258
285
HACFWVGCSRNGRPFKAKYKLVNHIRVH
FBpp0078477
C2H2 ZF
291
315
FACPHPGCGKVFARSENLKIHKRTH
FBpp0078477
C2H2 ZF
321
345
FKCEHEGCDRRFANSSDRKKHSHVH
FBpp0078477
C2H2 ZF
351
375
YNCRINGCDKSYTHPSSLRKHMKVH
Links
Other
C2H2 ZF
family TFs
Other
Drosophila melanogaster
TFs
64 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy