shn (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0003396 T114407_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator activity; and transcription corepressor activity. Involved in several processes, including digestive tract development; regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including ectoderm anlage; embryonic/larval gut; extended germ band embryo; germ layer; and ovary. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 43. Orthologous to several human genes including HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
shn
M06068_2.00		 Drosophila melanogaster
KGGAATYCCCT
AGGGRATTCCM		 B1H
Zhu et al.(2011)
shn-F1-2_SANGER_5_FBgn0003396		 (Direct) (Direct)
shn
M09663_2.00		 Drosophila melanogaster
TGWTTWKMYTGSKT
AMSCARKMWAAWCA		 Misc
Kulakovskiy et al.(2009)
shn		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0087200 C2H2 ZF 439 461
FBpp0087200 C2H2 ZF 467 491
FBpp0087200 C2H2 ZF 1771 1793
FBpp0087200 C2H2 ZF 1799 1823
FBpp0087200 C2H2 ZF 2262 2283
FBpp0087200 C2H2 ZF 2289 2313
FBpp0087200 C2H2 ZF 2334 2358
FBpp0087201 C2H2 ZF 439 461
FBpp0087201 C2H2 ZF 467 491
FBpp0087201 C2H2 ZF 1771 1793
FBpp0087201 C2H2 ZF 1799 1823
FBpp0087201 C2H2 ZF 2262 2283
FBpp0087201 C2H2 ZF 2289 2313
FBpp0087201 C2H2 ZF 2334 2358
FBpp0087202 C2H2 ZF 439 461
FBpp0087202 C2H2 ZF 467 491
FBpp0087202 C2H2 ZF 1771 1793
FBpp0087202 C2H2 ZF 1799 1823
FBpp0087202 C2H2 ZF 2262 2283
FBpp0087202 C2H2 ZF 2289 2313
FBpp0087202 C2H2 ZF 2334 2358
FBpp0089118 C2H2 ZF 484 506
FBpp0089118 C2H2 ZF 512 536
FBpp0089118 C2H2 ZF 1816 1838
FBpp0089118 C2H2 ZF 1844 1868
FBpp0089118 C2H2 ZF 2307 2328
FBpp0089118 C2H2 ZF 2334 2358
FBpp0089118 C2H2 ZF 2379 2403
FBpp0303469 C2H2 ZF 439 461
FBpp0303469 C2H2 ZF 467 491
FBpp0303469 C2H2 ZF 1771 1793
FBpp0303469 C2H2 ZF 1799 1823
FBpp0303469 C2H2 ZF 2262 2283
FBpp0303469 C2H2 ZF 2289 2313
FBpp0303469 C2H2 ZF 2334 2358
FBpp0303470 C2H2 ZF 484 506
FBpp0303470 C2H2 ZF 512 536
FBpp0303470 C2H2 ZF 1816 1838
FBpp0303470 C2H2 ZF 1844 1868
FBpp0303470 C2H2 ZF 2307 2328
FBpp0303470 C2H2 ZF 2334 2358
FBpp0303470 C2H2 ZF 2379 2403

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

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12 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action