TF Information

GIS1 *(Saccharomyces cerevisiae)* C2H2 ZF
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00096 (zf-C2H2)	IPR007087	YDR096W	T131828_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3-methyl-lysine-36 demethylase activity. Involved in histone demethylation and regulation of cellular biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4A (lysine demethylase 4A); KDM4B (lysine demethylase 4B); and KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
GIS1 M00019_2.00	Saccharomyces cerevisiae	NCCCCTWDNN	NNHWAGGGGN	PBM Badis et al.(2008) GIS1_4481	(Direct)	(Direct)
GIS1 M07449_2.00	Saccharomyces cerevisiae	HCCCCTWDN	NHWAGGGGD	PBM, CSA and or DIP-chip Mathelier et al.(2014) MA0306.1	(Direct)	(Direct)
GIS1 M08515_2.00	Saccharomyces cerevisiae	HCCCCTWDN	NHWAGGGGD	Misc DeBoer et al.(2011) YDR096W_562	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
RPH1 M00025_2.00	Saccharomyces cerevisiae	NNHCCCCTAAN	NTTAGGGGDNN	PBM Badis et al.(2008) RPH1_4571	0.816	0.911
RPH1 M01531_2.00	Saccharomyces cerevisiae	YNMCCCCTWWWW	WWWWAGGGGKNR	PBM Zhu et al.(2009) Rph1	0.816	0.911
RPH1 M07455_2.00	Saccharomyces cerevisiae	NCCCCTWA	TWAGGGGN	PBM, CSA and or DIP-chip Mathelier et al.(2014) MA0372.1	0.816	0.911
RPH1 M08522_2.00	Saccharomyces cerevisiae	NCCCCTWA	TWAGGGGN	Misc DeBoer et al.(2011) YER169W_547	0.816	0.911
For this family, TFs with SR scores > 0.755* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M00019_2.00	C2H2 ZF	50	73	YICRECNRQFSSGHHLTRHKKSVH
M00019_2.00	C2H2 ZF	79	100	HSCPRCGKRFKRRDHVLQHLNK

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
YDR096W	C2H2 ZF	828	851	YICRECNRQFSSGHHLTRHKKSVH
YDR096W	C2H2 ZF	857	878	HSCPRCGKRFKRRDHVLQHLNK

Links
Other C2H2 ZF family TFs
Other *Saccharomyces cerevisiae* TFs

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35 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action