TF Information

MET31 *(Saccharomyces cerevisiae)* C2H2 ZF
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00096 (zf-C2H2)	IPR007087	YPL038W	T131855_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables ATP hydrolysis activity. A structural constituent of cytoskeleton. Contributes to histone acetyltransferase activity. Involved in several processes, including ascospore wall assembly; mitotic actomyosin contractile ring contraction; and vacuole inheritance. Located in actin cytoskeleton. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and Swr1 complex. Used to study Moyamoya disease; autosomal dominant nonsyndromic deafness 20; patent ductus arteriosus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome; artery disease (multiple); atrial heart septal defect 5; intrinsic cardiomyopathy (multiple); and myopathy (multiple). Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
MET31 M00040_2.00	Saccharomyces cerevisiae	NNHCACCTMN	NKAGGTGDNN	PBM Badis et al.(2008) MET31_2146	(Direct)	(Direct)
MET31 M07470_2.00	Saccharomyces cerevisiae	MGCCACNNH	DNNGTGGCK	PBM, CSA and or DIP-chip Mathelier et al.(2014) MA0333.1	(Direct)	(Direct)
MET31 M08543_2.00	Saccharomyces cerevisiae	VCACWVYK	MRBWGTGB	Misc DeBoer et al.(2011) YPL038W_1370	(Direct)	(Direct)
MET31 M10402_2.00	Saccharomyces cerevisiae	Transfac license required	Transfac license required	Transfac Matys et al.(2006) F$MET31_01	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
MET32 M00022_2.00	Saccharomyces cerevisiae	NVMGCCACAV	BTGTGGCKBN	PBM Badis et al.(2008) MET32_2153	0.773	0.778
MET32 M01528_2.00	Saccharomyces cerevisiae	MGCCACAN	NTGTGGCK	PBM Zhu et al.(2009) Met32	0.773	0.778
MET32 M07452_2.00	Saccharomyces cerevisiae	MGCCACM	KGTGGCK	PBM, CSA and or DIP-chip Mathelier et al.(2014) MA0334.1	0.773	0.778
MET32 M08518_2.00	Saccharomyces cerevisiae	VHKCCACA	TGTGGMDB	Misc DeBoer et al.(2011) YDR253C_1375	0.773	0.778
For this family, TFs with SR scores > 0.755* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M00040_2.00	C2H2 ZF	51	73	YSCAKCQLKFSRSSDLRRHEKVH
M00040_2.00	C2H2 ZF	79	100	HICSNCGKGFARKDALKRHSNT

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
YPL038W	C2H2 ZF	95	117	YSCAKCQLKFSRSSDLRRHEKVH
YPL038W	C2H2 ZF	123	144	HICSNCGKGFARKDALKRHSNT

Links
Other C2H2 ZF family TFs
Other *Saccharomyces cerevisiae* TFs

Invalid Input OrderBy

28 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action