YPR015C (Saccharomyces cerevisiae)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 YPR015C T131858_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II complex binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone binding activity. Involved in several processes, including chromosome organization; regulation of cell cycle process; and regulation of nucleobase-containing compound metabolic process. Located in cellular bud neck; endoplasmic reticulum; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Used to study cancer. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; prostate cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to several human genes including CDK1 (cyclin dependent kinase 1) and CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
YPR015C
M01540_2.00		 Saccharomyces cerevisiae
YTSBBBN
NVVVSAR		 PBM
Zhu et al.(2009)
Ypr015c		 (Direct) (Direct)
YPR015C
M08546_2.00		 Saccharomyces cerevisiae
BNNNDVCGTAAATCMYNDHH
DDHNRKGATTTACGBHNNNV		 Misc
DeBoer et al.(2011)
YPR015C_871		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CMR3
M00042_2.00 		Saccharomyces cerevisiae
HGTARATCN
NGATYTACD		 PBM
Badis et al.(2008)
YPR013C_2104 		0.776 0.848
CMR3
M01539_2.00 		Saccharomyces cerevisiae
NGATYDRCVN
NBGYHRATCN		 PBM
Zhu et al.(2009)
Ypr013c 		0.776 0.848
CMR3
M07471_2.00 		Saccharomyces cerevisiae
NGATYKRCR
YGYMRATCN		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0434.1 		0.776 0.848
CMR3
M08545_2.00 		Saccharomyces cerevisiae
NNNRVYGTARATCMYDNNNN
NNNNHRKGATYTACRBYNNN		 Misc
DeBoer et al.(2011)
YPR013C_859 		0.776 0.848
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01540_2.00 C2H2 ZF 185 207
M01540_2.00 C2H2 ZF 213 237

DNA Binding Domains

Protein ID Domain From To Sequence
YPR015C C2H2 ZF 185 207
YPR015C C2H2 ZF 213 237

Links

Other C2H2 ZF family TFs
Other Saccharomyces cerevisiae TFs

Invalid Input OrderBy

24 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action