KDM2B (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSG00000089094 T167980_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Homo sapiens

Weirauch et al.(2014)
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Danio rerio

Weirauch et al.(2014)
1.000 1.000
Meleagris gallopavo

Weirauch et al.(2014)
0.947 0.947
Tetraodon nigroviridis

Weirauch et al.(2014)
0.894 0.894
Danio rerio

Weirauch et al.(2014)
0.851 0.851
Bombyx mori

Weirauch et al.(2014)
0.789 0.789
Danio rerio

Weirauch et al.(2014)
0.737 0.737
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01911_2.00 CxxC 51 97

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000366269 CxxC 574 620
ENSP00000366271 CxxC 605 651
ENSP00000437821 CxxC 1 19
ENSP00000445196 CxxC 605 651
ENSP00000480847 CxxC 488 534


Other CxxC family TFs
Other Homo sapiens TFs

270 Related TFs

Name Species Gene ID Motif Evidence SR
A6H8I1_DANRE Danio rerio A6H8I1_DANRE D 0.851
AAEL008177 Aedes aegypti AAEL008177 I 0.789
AAH82636 Xenopus laevis AAH82636 I 1.000
AALB008825 Anopheles albimanus AALB008825 I 0.789
Aan_R010310 Calypte anna Aan_R010310 I 1.000
Aan_R013926 Calypte anna Aan_R013926 I 0.895
AARA007034 Anopheles arabiensis AARA007034 I 0.789
AATE012597 Anopheles atroparvus AATE012597 I 0.789
ACEP18719 Atta cephalotes ACEP18719 I 0.717
ACHR000854 Anopheles christyi ACHR000854 I 0.789
ACOM023689 Anopheles coluzzii ACOM023689 I 0.789
ACUA020146 Anopheles culicifacies ACUA020146 I 0.789
ACYPI010029 Acyrthosiphon pisum ACYPI010029 I 0.789
ADAC009986 Anopheles darlingi ADAC009986 I 0.789
ADIR003045 Anopheles dirus ADIR003045 I 0.789
AEPI004479 Anopheles epiroticus AEPI004479 I 0.789
AFAF017887 Anopheles farauti AFAF017887 I 0.789
Afo_R000853 Aptenodytes forsteri Afo_R000853 I 1.000
Afo_R005099 Aptenodytes forsteri Afo_R005099 I 0.895
AFUN000025 Anopheles funestus AFUN000025 I 0.789
AGAP001895 Anopheles gambiae AGAP001895 I 0.789
Alligator_sinensis_CCG000030.1 Alligator sinensis Alligator_sinensis_CCG000030.1 I 0.895
Alligator_sinensis_CCG006419.1 Alligator sinensis Alligator_sinensis_CCG006419.1 I 0.895
Alligator_sinensis_CCG016574.1 Alligator sinensis Alligator_sinensis_CCG016574.1 I 1.000
AMAM022796 Anopheles maculatus AMAM022796 I 0.789
AMEC007605 Anopheles melas AMEC007605 I 0.789
AMEM008208 Anopheles merus AMEM008208 I 0.789
AMIN000460 Anopheles minimus AMIN000460 I 0.789
AQUA007214 Anopheles quadriannulatus AQUA007214 I 0.789
ASIS005878 Anopheles sinensis ASIS005878 I 0.789
ASTEI08728 Anopheles stephensi ASTEI08728 I 0.789
BGIBMGA012843 Bombyx mori BGIBMGA012843 D 0.789
Brh_R009202 Buceros rhinoceros Brh_R009202 I 1.000
CapteG226024 Capitella teleta CapteG226024 I 0.702
Cflo_02982--XP_394324.2_APIME Camponotus floridanus Cflo_02982--XP_394324.2_APIME I 0.737
CGI_10025673 Crassostrea gigas CGI_10025673 I 0.842
CLEC002189 Cimex lectularius CLEC002189 I 0.789
Cmyd_10001861 Chelonia mydas Cmyd_10001861 I 0.895
Cmyd_10015637 Chelonia mydas Cmyd_10015637 I 1.000
CPIJ008371 Culex quinquefasciatus CPIJ008371 I 0.789
CpipJ_CPIJ008371 Culex pipiens CpipJ_CPIJ008371 I 0.789
KDM2B Anolis carolinensis ENSACAG00000001871 I 0.778
KDM2A Anolis carolinensis ENSACAG00000007630 I 0.895
FBXL19 Anolis carolinensis ENSACAG00000007651 I 0.915
ENSAMEG00000000531 Ailuropoda melanoleuca ENSAMEG00000000531 I 0.895
ENSAMEG00000007582 Ailuropoda melanoleuca ENSAMEG00000007582 I 0.895
ENSAMEG00000014308 Ailuropoda melanoleuca ENSAMEG00000014308 I 1.000
ENSAMXG00000005838 Astyanax mexicanus ENSAMXG00000005838 I 1.000
ENSAMXG00000008005 Astyanax mexicanus ENSAMXG00000008005 I 0.895
ENSAMXG00000009823 Astyanax mexicanus ENSAMXG00000009823 I 0.737
ENSAMXG00000015501 Astyanax mexicanus ENSAMXG00000015501 I 0.737
ENSAMXG00000020635 Astyanax mexicanus ENSAMXG00000020635 I 0.842
ENSAPLG00000003636 Anas platyrhynchos ENSAPLG00000003636 I 0.895
ENSAPLG00000004534 Anas platyrhynchos ENSAPLG00000004534 I 1.000
KDM2B Bos taurus ENSBTAG00000002328 I 1.000
FBXL19 Bos taurus ENSBTAG00000040555 I 0.895
KDM2A Bos taurus ENSBTAG00000044032 I 0.895
KDM2B Canis familiaris ENSCAFG00000008259 I 1.000
KDM2A Canis familiaris ENSCAFG00000011792 I 0.895
FBXL19 Canis familiaris ENSCAFG00000016736 I 0.895
KDM2A Choloepus hoffmanni ENSCHOG00000006440 I 0.895
KDM2A Callithrix jacchus ENSCJAG00000001071 I 0.895
KDM2B Callithrix jacchus ENSCJAG00000001555 I 1.000
FBXL19 Callithrix jacchus ENSCJAG00000002985 I 0.895
KDM2A Cavia porcellus ENSCPOG00000007134 I 0.895
KDM2B Cavia porcellus ENSCPOG00000011011 I 1.000
FBXL19 Cavia porcellus ENSCPOG00000022362 I 0.895
ENSCSAG00000002201 Chlorocebus sabaeus ENSCSAG00000002201 I 1.000
ENSCSAG00000005806 Chlorocebus sabaeus ENSCSAG00000005806 I 0.895
ENSCSAG00000008476 Chlorocebus sabaeus ENSCSAG00000008476 I 0.895
kdm2ba Danio rerio ENSDARG00000036593 D 1.000
kdm2bb Danio rerio ENSDARG00000046010 I 1.000
kdm2aa Danio rerio ENSDARG00000059653 D 0.737
kdm2ab Danio rerio ENSDARG00000078133 I 0.737
KDM2A Dasypus novemcinctus ENSDNOG00000002051 I 0.895
KDM2B Dasypus novemcinctus ENSDNOG00000013082 I 1.000
FBXL19 Dasypus novemcinctus ENSDNOG00000035206 I 0.895
ENSDORG00000006710 Dipodomys ordii ENSDORG00000006710 I 1.000
Fbxl19 Dipodomys ordii ENSDORG00000010635 I 0.895
FBXL19 Equus caballus ENSECAG00000018851 I 0.895
KDM2B Equus caballus ENSECAG00000021840 I 1.000
KDM2A Equus caballus ENSECAG00000025072 I 0.895
FBXL19 Erinaceus europaeus ENSEEUG00000001272 I 0.895
KDM2A Erinaceus europaeus ENSEEUG00000010174 I 0.895
KDM2A Echinops telfairi ENSETEG00000009328 I 0.895
ENSFALG00000009151 Ficedula albicollis ENSFALG00000009151 I 1.000
ENSFALG00000012392 Ficedula albicollis ENSFALG00000012392 I 0.895
FBXL19 Felis catus ENSFCAG00000002585 I 0.895
KDM2A Felis catus ENSFCAG00000003383 I 0.895
KDM2B Felis catus ENSFCAG00000012455 I 1.000
FBXL19 Homo sapiens ENSG00000099364 I 0.895
KDM2A Homo sapiens ENSG00000173120 I 0.895
kdm2ba Gasterosteus aculeatus ENSGACG00000011854 I 1.000
FBXL19 Gasterosteus aculeatus ENSGACG00000014763 I 0.895
kdm2aa Gasterosteus aculeatus ENSGACG00000016421 I 0.737
kdm2bb Gasterosteus aculeatus ENSGACG00000017026 I 1.000
ENSGALG00000004225 Gallus gallus ENSGALG00000004225 I 1.000
ENSGALG00000013286 Gallus gallus ENSGALG00000013286 I 0.895
KDM2A Gorilla gorilla ENSGGOG00000001636 I 0.895
FBXL19 Gorilla gorilla ENSGGOG00000003625 I 0.895
KDM2B Gorilla gorilla ENSGGOG00000014021 I 1.000
ENSGMOG00000011590 Gadus morhua ENSGMOG00000011590 I 0.895
ENSGMOG00000014213 Gadus morhua ENSGMOG00000014213 I 0.789
ENSGMOG00000015869 Gadus morhua ENSGMOG00000015869 I 1.000
ENSLACG00000006471 Latimeria chalumnae ENSLACG00000006471 I 0.936
ENSLACG00000012832 Latimeria chalumnae ENSLACG00000012832 I 0.895
ENSLACG00000018441 Latimeria chalumnae ENSLACG00000018441 I 1.000
KDM2A Loxodonta africana ENSLAFG00000006277 I 0.895
KDM2B Loxodonta africana ENSLAFG00000027865 I 1.000
FBXL19 Loxodonta africana ENSLAFG00000030638 I 0.895
ENSLOCG00000005104 Lepisosteus oculatus ENSLOCG00000005104 I 1.000
ENSLOCG00000008268 Lepisosteus oculatus ENSLOCG00000008268 I 0.789
ENSMEUG00000001808 Macropus eugenii ENSMEUG00000001808 I 1.000
ENSMEUG00000003370 Macropus eugenii ENSMEUG00000003370 I 0.895
ENSMEUG00000004320 Macropus eugenii ENSMEUG00000004320 I 0.895
KDM2B Meleagris gallopavo ENSMGAG00000004301 I 1.000
KDM2A Meleagris gallopavo ENSMGAG00000010309 D 0.809
FBXL19 Microcebus murinus ENSMICG00000001566 I 0.895
KDM2A Microcebus murinus ENSMICG00000004044 I 0.895
KDM2B Microcebus murinus ENSMICG00000015572 I 1.000
KDM2A Myotis lucifugus ENSMLUG00000005065 I 0.895
KDM2B Myotis lucifugus ENSMLUG00000013315 I 1.000
KDM2A Macaca mulatta ENSMMUG00000008771 I 0.895
KDM2B Macaca mulatta ENSMMUG00000021564 I 1.000
KDM2A Monodelphis domestica ENSMODG00000007767 I 0.895
ENSMODG00000009064 Monodelphis domestica ENSMODG00000009064 I 0.895
ENSMODG00000012065 Monodelphis domestica ENSMODG00000012065 I 1.000
ENSMPUG00000002104 Mustela putorius furo ENSMPUG00000002104 I 1.000
ENSMPUG00000003692 Mustela putorius furo ENSMPUG00000003692 I 0.895
ENSMPUG00000011968 Mustela putorius furo ENSMPUG00000011968 I 0.895
Kdm2b Mus musculus ENSMUSG00000029475 I 1.000
Fbxl19 Mus musculus ENSMUSG00000030811 I 0.895
Kdm2a Mus musculus ENSMUSG00000054611 I 0.895
ENSNLEG00000006301 Nomascus leucogenys ENSNLEG00000006301 I 0.895
ENSNLEG00000016063 Nomascus leucogenys ENSNLEG00000016063 I 0.895
ENSNLEG00000016168 Nomascus leucogenys ENSNLEG00000016168 I 1.000
ENSOARG00000008120 Ovis aries ENSOARG00000008120 I 0.895
ENSOARG00000009415 Ovis aries ENSOARG00000009415 I 0.895
ENSOARG00000013863 Ovis aries ENSOARG00000013863 N 1.000
KDM2B Oryctolagus cuniculus ENSOCUG00000005961 I 1.000
KDM2A Oryctolagus cuniculus ENSOCUG00000009988 I 0.895
FBXL19 Oryctolagus cuniculus ENSOCUG00000010641 I 0.895
KDM2B Otolemur garnettii ENSOGAG00000000881 I 1.000
KDM2A Otolemur garnettii ENSOGAG00000010623 I 0.895
FBXL19 Otolemur garnettii ENSOGAG00000014408 I 0.895
ENSOGAG00000033216 Otolemur garnettii ENSOGAG00000033216 I 0.947
ENSONIG00000005149 Oreochromis niloticus ENSONIG00000005149 I 0.702
ENSONIG00000009273 Oreochromis niloticus ENSONIG00000009273 I 0.895
ENSONIG00000010829 Oreochromis niloticus ENSONIG00000010829 I 1.000
ENSONIG00000013875 Oreochromis niloticus ENSONIG00000013875 I 1.000
ENSONIG00000018158 Oreochromis niloticus ENSONIG00000018158 I 0.737
KDM2A Ochotona princeps ENSOPRG00000013564 I 0.895
KDM2B Ochotona princeps ENSOPRG00000015228 I 1.000
FBXL19 Ochotona princeps ENSOPRG00000016023 I 0.895
kdm2ab Oryzias latipes ENSORLG00000003398 I 0.895
kdm2bb Oryzias latipes ENSORLG00000008562 I 1.000
kdm2aa Oryzias latipes ENSORLG00000011075 I 0.737
kdm2ba Oryzias latipes ENSORLG00000012943 I 1.000
ENSP00000366271 Macaca fascicularis ENSP00000366271 I 1.000
ENSP00000366271-D1 Bos grunniens ENSP00000366271-D1 I 1.000
ENSP00000369666 Macaca fascicularis ENSP00000369666 I 0.895
ENSP00000369666-D1 Bos grunniens ENSP00000369666-D1 I 0.895
ENSP00000384903 Macaca fascicularis ENSP00000384903 I 0.895
ENSP00000384903-D1 Bos grunniens ENSP00000384903-D1 I 0.895
ENSPANG00000010861 Papio anubis ENSPANG00000010861 I 0.895
ENSPANG00000010984 Papio anubis ENSPANG00000010984 I 1.000
ENSPANG00000019062 Papio anubis ENSPANG00000019062 I 0.895
KDM2B Procavia capensis ENSPCAG00000007401 I 1.000
FBXL19 Procavia capensis ENSPCAG00000010411 I 0.895
KDM2A Procavia capensis ENSPCAG00000011177 I 0.895
ENSPFOG00000008929 Poecilia formosa ENSPFOG00000008929 I 0.895
ENSPFOG00000009817 Poecilia formosa ENSPFOG00000009817 I 0.842
ENSPFOG00000011570 Poecilia formosa ENSPFOG00000011570 I 0.737
ENSPFOG00000016940 Poecilia formosa ENSPFOG00000016940 I 1.000
ENSPFOG00000019763 Poecilia formosa ENSPFOG00000019763 I 1.000
ENSPFOG00000021921 Poecilia formosa ENSPFOG00000021921 I 0.737
ENSPMAG00000006989 Petromyzon marinus ENSPMAG00000006989 I 0.947
ENSPPYG00000003001 Pongo abelii ENSPPYG00000003001 I 0.895
ENSPPYG00000005050 Pongo abelii ENSPPYG00000005050 I 1.000
ENSPPYG00000007294 Pongo abelii ENSPPYG00000007294 I 0.895
ENSPSIG00000002317 Pelodiscus sinensis ENSPSIG00000002317 I 0.895
ENSPSIG00000004862 Pelodiscus sinensis ENSPSIG00000004862 I 1.000
KDM2A Pan troglodytes ENSPTRG00000003945 I 0.895
KDM2B Pan troglodytes ENSPTRG00000005560 I 1.000
KDM2A Pteropus vampyrus ENSPVAG00000008538 I 0.895
KDM2B Pteropus vampyrus ENSPVAG00000010258 I 1.000
FBXL19 Pteropus vampyrus ENSPVAG00000011046 I 0.895
Fbxl19 Rattus norvegicus ENSRNOG00000018986 I 0.895
Kdm2a Rattus norvegicus ENSRNOG00000019145 I 0.895
Kdm2b Rattus norvegicus ENSRNOG00000025702 I 1.000
KDM2A Sorex araneus ENSSARG00000001832 I 0.895
KDM2B Sorex araneus ENSSARG00000008149 I 1.000
ENSSHAG00000000130 Sarcophilus harrisii ENSSHAG00000000130 I 0.895
ENSSHAG00000010625 Sarcophilus harrisii ENSSHAG00000010625 I 0.895
ENSSHAG00000011039 Sarcophilus harrisii ENSSHAG00000011039 I 0.895
ENSSHAG00000016744 Sarcophilus harrisii ENSSHAG00000016744 N 1.000
ENSSSCG00000009812 Sus scrofa ENSSSCG00000009812 I 1.000
FBXL19 Sus scrofa ENSSSCG00000028186 I 0.895
KDM2A Sus scrofa ENSSSCG00000029637 I 0.895
KDM2B Sus scrofa ENSSSCG00000029803 I 1.000
ENSSTOG00000003355 Ictidomys tridecemlineatus ENSSTOG00000003355 I 0.895
ENSSTOG00000005331 Ictidomys tridecemlineatus ENSSTOG00000005331 I 0.895
ENSSTOG00000027154 Ictidomys tridecemlineatus ENSSTOG00000027154 I 1.000
KDM2A Tupaia belangeri ENSTBEG00000003398 I 0.895
KDM2B Tupaia belangeri ENSTBEG00000016315 I 1.000
FBXL19 Tupaia belangeri ENSTBEG00000017146 I 0.895
KDM2A Taeniopygia guttata ENSTGUG00000005980 I 0.895
KDM2B Taeniopygia guttata ENSTGUG00000006001 I 1.000
kdm2aa Tetraodon nigroviridis ENSTNIG00000003239 I 0.737
FBXL19 Tetraodon nigroviridis ENSTNIG00000006493 D 0.895
ENSTNIG00000009085 Tetraodon nigroviridis ENSTNIG00000009085 I 1.000
kdm2ab Tetraodon nigroviridis ENSTNIG00000013139 N 0.842
FBXL19 Takifugu rubripes ENSTRUG00000000468 I 0.895
kdm2ba Takifugu rubripes ENSTRUG00000005276 I 1.000
kdm2aa Takifugu rubripes ENSTRUG00000005339 I 0.737
kdm2bb Takifugu rubripes ENSTRUG00000010230 I 1.000
kdm2ab Takifugu rubripes ENSTRUG00000013920 N 0.842
ENSTSYG00000014726 Tarsius syrichta ENSTSYG00000014726 I 0.895
KDM2B Tursiops truncatus ENSTTRG00000014294 I 0.962
FBXL19 Tursiops truncatus ENSTTRG00000015474 I 0.895
KDM2A Vicugna pacos ENSVPAG00000010644 I 0.895
ENSXMAG00000009962 Xiphophorus maculatus ENSXMAG00000009962 I 0.842
ENSXMAG00000014057 Xiphophorus maculatus ENSXMAG00000014057 I 1.000
ENSXMAG00000015174 Xiphophorus maculatus ENSXMAG00000015174 I 1.000
ENSXMAG00000015985 Xiphophorus maculatus ENSXMAG00000015985 I 0.737
ENSXMAG00000018857 Xiphophorus maculatus ENSXMAG00000018857 I 0.895
e_gw.283.81.1 Branchiostoma floridae e_gw.283.81.1 I 0.842
GB55352 Apis mellifera GB55352 I 0.739
Gfo_R003115 Geospiza fortis Gfo_R003115 I 1.000
Gfo_R013488 Geospiza fortis Gfo_R013488 I 0.895
gw.77.244.1 Branchiostoma floridae gw.77.244.1 I 0.842
HelroG180456 Helobdella robusta HelroG180456 I 0.842
HHAL000649-PA Halyomorpha halys HHAL000649-PA I 0.842
HMEL006876 Heliconius melpomene HMEL006876 I 0.789
Hsal_05571--XP_394324.2_APIME Harpegnathos saltator Hsal_05571--XP_394324.2_APIME I 0.737
ISCW018631 Ixodes scapularis ISCW018631 I 0.947
KGM_15455 Danaus plexippus KGM_15455 I 0.789
L798_05577 Zootermopsis nevadensis L798_05577 I 0.789
LCUP018230 Lucilia cuprina LCUP018230 I 0.702
LotgiG52553 Lottia gigantea LotgiG52553 I 0.895
MDOA010969 Musca domestica MDOA010969 I 0.702
Myotis_brandtii_FBXL19_10014496 Myotis brandtii Myotis_brandtii_FBXL19_10014496 I 0.895
Myotis_brandtii_KDM2A_10030797 Myotis brandtii Myotis_brandtii_KDM2A_10030797 I 0.895
Myotis_brandtii_KDM2B_10021721 Myotis brandtii Myotis_brandtii_KDM2B_10021721 I 1.000
NEMVEDRAFT_v1g242923 Nematostella vectensis NEMVEDRAFT_v1g242923 I 0.842
NV12279 Nasonia vitripennis NV12279 I 0.737
Ocbimv22016485m.g Octopus bimaculoides Ocbimv22016485m.g I 0.947
Ogr01308 Ophisaurus gracilis Ogr01308 I 0.979
Ogr05591 Ophisaurus gracilis Ogr05591 I 0.915
Ogr08491 Ophisaurus gracilis Ogr08491 I 0.895
PHUM316810 Pediculus humanus PHUM316810 I 0.766
PPAI007950 Phlebotomus papatasi PPAI007950 I 0.789
Pvit_05476 Pogona vitticeps Pvit_05476 I 0.915
Pvit_05626 Pogona vitticeps Pvit_05626 I 1.000
Pvit_16205 Pogona vitticeps Pvit_16205 I 0.895
RPRC001022 Rhodnius prolixus RPRC001022 I 0.723
Sakowv30010450m.g Saccoglossus kowalevskii Sakowv30010450m.g I 0.842
SMAR015271 Strigamia maritima SMAR015271 I 0.894
SPU_002864 Strongylocentrotus purpuratus SPU_002864 I 0.895
SPU_003593 Strongylocentrotus purpuratus SPU_003593 I 0.895
Tal_R002927 Tyto alba Tal_R002927 I 1.000
TC015153 Tribolium castaneum TC015153 I 0.789
tetur13g02300 Tetranychus urticae tetur13g02300 I 0.947
kdm2a Xenopus tropicalis XB-GENE-5900838 I 0.895
kdm2b Xenopus tropicalis XB-GENE-990506 I 1.000
kdm2b.L Xenopus laevis XB-GENE-990512 I 1.000
fbxl19 Xenopus tropicalis XB-GENE-994853 I 0.895
fbxl19.S Xenopus laevis XB-GENE-994856 I 0.895
YQE_02168 Dendroctonus ponderosae YQE_02168 I 0.789